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MR 24

Catalog #: 8122 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8122/50
8122/10
MR 24 | Other Kinase Inhibitors
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Description: Potent and selective MST3 kinase binding inhibitor

Chemical Name: 8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride

Purity: ≥98%

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Biological Activity

MR 24 is a potent and selective MST3 kinase binding inhibitor with >10 fold selectivity over MST4 (EC50 values from NanoBRET assay are 57 nM and 583 nM for MST3 and MST4 respectively). MR 24 increases the number of cells in G1 phase of cell cycle, is non-cytotoxic and cell permeable. Shows 90% stability over 1 hour in activated liver microsomes in vivo.

Technical Data

M.Wt:
618.38
Formula:
C26H29ClN6O3.3HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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