Home / P2Y Receptor Agonists / MRS 2693 trisodium salt

MRS 2693 trisodium salt

Catalog #: 2502
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2502/1
MRS 2693 trisodium salt | CAS No. 1448858-83-0 | P2Y Receptor Agonists
1 Image
Description: Selective P2Y6 agonist
Alternative Names: 5-Iodo-UDP trisodium salt

Chemical Name: 5-Iodouridine-5'-O-diphosphate trisodium salt

Purity: ≥95%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MRS 2693 trisodium salt is a selective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor). Displays no activity at other P2Y subtypes. Exerts a cytoprotective effect in an in vivo mouse model of hindlimb skeletal muscle ischemia/reperfusion injury.

Technical Data

M.Wt:
596
Formula:
C9H10IN2Na3O12P2
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1448858-83-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
    Besada et al.
    J.Med.Chem., 2006;49:5532
  2. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.
    Mamedova et al.
    Pharmacol.Res., 2008;58:232
  3. Development of selective agonists and antagonists of P2Y receptors.
    Jacobson et al.
    Purinerg.Sig., 2009;5:75

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for MRS 2693 trisodium salt

The citations listed below are publications that use Tocris products. Selected citations for MRS 2693 trisodium salt include:

4 Citations: Showing 1 - 4

  1. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Neuropharmacology  2015;11:1114
  2. Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages.
    Authors: Moreira-Souza Et al.
    PLoS One  2015;10:e0133502
  3. Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway.
    Authors: Yu Et al.
    FASEB J  2013;27:1895
  4. Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats.
    Authors: Matsumoto Et al.
    Am J Physiol Heart Circ Physiol  2011;301:H409

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for MRS 2693 trisodium salt

There are currently no reviews for this product. Be the first to review MRS 2693 trisodium salt and earn rewards!

Have you used MRS 2693 trisodium salt?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.