NBI 31772
Chemical Name: 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
Purity: ≥98%
Biological Activity
NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery of a series of nonpeptide small molecules that inhibit the binding of Ins-like growth factor (IGF) to IGF-binding proteins.
Chen et al.
J.Med.Chem., 2001;44:4001 -
In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.
Choi et al.
Development., 2013;140:660
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for NBI 31772
The citations listed below are publications that use Tocris products. Selected citations for NBI 31772 include:
2 Citations: Showing 1 - 2
-
Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration.
Authors: Ichijo Et al.
Nat Commun 2017;8:508
-
An O-Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin.
Authors: Markus Et al.
J Bone Miner Res 2017;32:70-81
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for NBI 31772
There are currently no reviews for this product. Be the first to review NBI 31772 and earn rewards!
Have you used NBI 31772?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
