Home / Inflammasomes Inhibitors / NDT 30805

NDT 30805

Catalog #: 7808 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7808/2
NDT 30805 | Inflammasomes Inhibitors
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Description: Potent NLRP3 inflammasome inhibitor

Chemical Name: 2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione

Purity: ≥95%

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Biological Activity

NDT 30805 is a potent NLRP3 inflammasome inhibitor. Inhibits IL-1β release in peripheral blood mononuclear cell assay, ASC speck assay and in whole blood (IC50 values are 13 nM, 34 nM and 1500 nM). Inhibits Nigericin (Cat. No. 4312) and ATP-induced IL-1β release. Soluble and uncharged at physiological pH.

Technical Data

M.Wt:
414.53
Formula:
C23H22N6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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