Nelarabine
Chemical Name: 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Purity: ≥98%
Biological Activity
Nelarabine is a nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.
Lambe et al.
Cancer Res., 1995;55:3352 -
Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia.
Reilly and Kisor et al.
OncoTargets Ther., 2009;2:219 -
In vitro cytotoxicity of nelarabine, clofar. and flavopiridol in paediatric acute lymphoblastic leukaemia.
Beesley et al.
Br.J.Haematol., 2007;137:109
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