NF 023

Catalog # Availability Size / Price Qty
1240/10
1240/50
NF 023 | CAS No. 104869-31-0 | P2X Receptor Antagonists
1 Image
Description: Selective and competitive P2X1 antagonist

Chemical Name: 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt

Product Details
Citations (10)
Supplemental Products
Reviews

Biological Activity

NF 023 is an a subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i (EC50 ~300 nM). Also inhibits DNA-binding activity of HMGA2 (IC50 = 10.63 μM).

Technical Data

M.Wt:
1162.86
Formula:
C35H20N4Na6O21S6
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
104869-31-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for NF 023

The citations listed below are publications that use Tocris products. Selected citations for NF 023 include:

10 Citations: Showing 1 - 10

  1. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
    Authors: Su Et al.
    Sci Rep  2020;10:18850
  2. Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors.
    Authors: Gao Et al.
    Virulence  2018;9:1601
  3. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
    Authors: Ledderose Et al.
    J Infect Dis  2016;213:456
  4. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  5. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
    Authors: Ren Et al.
    Emerg Microbes Infect  2014;3:e62
  6. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
    Authors: Beckham Et al.
    Oncogenesis  2013;2:e49
  7. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol  2012;92:787
  8. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.
    Authors: Donnelly-Roberts Et al.
    Br J Pharmacol  2009;157:1203
  9. Purinergic and nitrergic junction potential in the human colon.
    Authors: Gallego Et al.
    Am J Physiol Gastrointest Liver Physiol  2008;295:G522
  10. Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat.
    Authors: Labrakakis Et al.
    J Physiol  2003;549:131

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NF 023

There are currently no reviews for this product. Be the first to review NF 023 and earn rewards!

Have you used NF 023?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.