NF 157
Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity: ≥90%
Biological Activity
NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM). Displays selectivity for P2Y11 and P2X1 receptors over P2Y1, P2Y2, P2X2, P2X3, P2X4 and P2X7 receptors. Inhibits NAD+-induced activation of human granulocytes.This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.
Ullmann et al.
J.Med.Chem., 2005;48:7040 -
Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.
Moreschi et al.
J.Biol.Chem., 2006;281:31419
Product Datasheets
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Citations for NF 157
The citations listed below are publications that use Tocris products. Selected citations for NF 157 include:
12 Citations: Showing 1 - 10
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Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
Authors: Dosch Et al.
Elife 2019;8
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Antagonism of P2Y11 receptor (P2Y11R) protects epidermal stem cells against UV-B irradiation.
Authors: Wu Et al.
Am J Transl Res 2019;11:4738
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Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes.
Authors: Kinoshita Et al.
EBioMedicine 2018;32:72
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Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling
Authors: Avanzato Et al.
Scientific Reports 2016;6:32602
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Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
Authors: Ledderose Et al.
J Infect Dis 2016;213:456
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Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
Authors: Braganhol Et al.
Biochim Biophys Acta 2015;1852:120
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The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
Authors: Nishimura Et al.
PLoS Pathog 2015;11:e1005184
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Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
Authors: Kawano Et al.
PLoS One 2015;10:e0127919
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The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
Authors: Ren Et al.
Emerg Microbes Infect 2014;3:e62
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ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
Authors: Manohar Et al.
J Leukoc Biol 2012;92:787
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Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.
Authors: Ohtomo Et al.
Invest Ophthalmol Vis Sci 2011;52:9503
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Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts.
Authors: Talasila Et al.
Br J Pharmacol 2009;158:339
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