Nicotinamide
Chemical Name: Pyridine-3-carboxamide
Purity: ≥99%
Biological Activity
Nicotinamide is an anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration. Nicotinamide also acts as a SIRT1 inhibitor and promotes the expansion of hematopoietic progenitor cellsNicotinamide synthesized to Ancillary Material Grade also available.
For more information about how Nicotinamide may be used, see our protocol:
3D Culture of Lung Alveolar CellsTechnical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Organoid Models of Human and Mouse Ductal Pancreatic Cancer.
Boj SF, Hwang C, Baker LA et al.
Cell. -
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death.
Cimadamore et al.
Stem Cells., 2009;27:1772 -
A modified method of Ins producing cells' generation from bone marrow-derived mesenchymal stem cells.
Czubak et al.
J.Diabetes Res., 2014;2014:628591 -
Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake.
Suzuki et al.
Life.Sci., 2010;86:676 -
SnapShot: Growing Organoids from Stem Cells.
Sato et al.
Cell, 2015;161:1700 -
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld et al.
Gastroenterology, 2015;148:126 -
Isolation and in vitro expansion of human colonic stem cells.
Jung et al.
Nat.Med., 2011;17:1227
Product Datasheets
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Citations for Nicotinamide
The citations listed below are publications that use Tocris products. Selected citations for Nicotinamide include:
6 Citations: Showing 1 - 6
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INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury.
Authors: Steven L Et al.
Nat Commun 2022;13:6037
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Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy.
Authors: Emanuela Et al.
Elife 2020;9
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Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology.
Authors: Mihee M Et al.
Curr Protoc Pharmacol 2019;85:e54
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Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway.
Authors: Mark R Et al.
DNA Repair (Amst) 2019;82:102675
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Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity.
Authors: Thomas C Et al.
Cell Stem Cell 2019;25:103-119.e6
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Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Authors: Jun Et al.
Cell 2017;169:243-257.e25
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