Nitazoxanide
Chemical Name: 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
Purity: ≥98%
Biological Activity
Nitazoxanide is a pyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor. Also inhibits Wnt signaling by stabilization of peptidyl arginine deiminase 2 (PAD2). Broad-spectrum antiparasitic and antiviral. Inhibits SARS-CoV-2 infection in Vero E6 cells (EC50 = 2.12μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Wang et al.
Cell Research, 2020;30:269 -
Update on Nitazoxanide: a multifunctional chemotherapeutic agent.
Shakya et al.
Curr.Drug Discov.Technol., 2018;15:201 -
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.
Qu et al.
Nat.Chem.Biol., 2017;14:94
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