NITD 008
Chemical Name: 7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: ≥97%
Biological Activity
NITD 008 is a selective flavivirus inhibitor. Adenosine analog. Inhibits dengue virus (EC50 = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. Reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An adenosine nucleoside inhibitor of dengue virus.
Yin et al.
Proc.Natl.Acad.Sci.USA., 2009;106:20435 -
A screen of FDA-approved drugs for inhibitors of Zika virus infection.
Barrows et al.
Cell.Host.Microbe., 2016;20:259
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