NKY 80
Chemical Name: 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Purity: ≥98%
Biological Activity
NKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms.
Onda et al.
J.Biol.Chem., 2001;276:47785 -
Capturing adenylyl cyclases as potential drug targets.
Pierre et al.
Nat.Rev.Drug Discov., 2009;8:321
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Citation for NKY 80
The citations listed below are publications that use Tocris products. Selected citations for NKY 80 include:
1 Citation: Showing 1 - 1
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In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain.
Authors: Jun Et al.
Neuron 2020;105:799-812.e5
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