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NS 19504

Catalog #: 5276 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5276/10
5276/50
NS 19504 | CAS No. 327062-46-4 | Ca2+-Activated Potassium Channel Activators
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Description: KCa1.1 (BK) channel activator

Chemical Name: 5-[(4-Bromophenyl)methyl]-2-thiazolamine

Purity: ≥99%

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Biological Activity

NS 19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.

Technical Data

M.Wt:
269.16
Formula:
C10H9BrN2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
327062-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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