NS 2028
Chemical Name: 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
Purity: ≥98%
Biological Activity
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase.
von Wantoch Rekowski et al.
Bioorg.Med.Chem., 2010;18:1288 -
The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.
Morbidelli et al.
Am.J.Physiol.Regul.Integr.Comp.Physiol., 2010;298:R824 -
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
Olesen et al.
Br.J.Pharmacol., 1998;123:299
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Citation for NS 2028
The citations listed below are publications that use Tocris products. Selected citations for NS 2028 include:
1 Citation: Showing 1 - 1
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17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase.
Authors: Ping Et al.
J Biol Chem 2019;294:15577-15592
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