NSC 617145
Chemical Name: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Purity: ≥98%
Biological Activity
NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Aggarwal et al.
Cancer Res., 2013;73:5497 -
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.
Aggarwal et al.
Cell Cycle, 2013;12:3329
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for NSC 617145
The citations listed below are publications that use Tocris products. Selected citations for NSC 617145 include:
1 Citation: Showing 1 - 1
-
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.
Authors: Robert H Et al.
Nat Commun 2021;12:6561
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for NSC 617145
There are currently no reviews for this product. Be the first to review NSC 617145 and earn rewards!
Have you used NSC 617145?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
