Home / Other Wnt Signaling Inhibitors / NSC 668036

NSC 668036

Catalog #: 5813
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5813/10
5813/50
NSC 668036 | CAS No. 144678-63-7 | Other Wnt Signaling Inhibitors
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Description: Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein

Chemical Name: N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NSC 668036 is a Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.

Technical Data

M.Wt:
460.52
Formula:
C21H36N2O9
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
144678-63-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for NSC 668036

The citations listed below are publications that use Tocris products. Selected citations for NSC 668036 include:

3 Citations: Showing 1 - 3

  1. The Wnt pathway protein Dvl1 targets Somatostatin receptor 2 for lysosome-dependent degradation.
    Authors: Carr Et al.
    J.Biol.Chem.  2023;299:104645
  2. Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells.
    Authors: Ming Et al.
    Elife  2022;11
  3. Inhibition of Wnt-β-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells.
    Authors: Carlos Et al.
    Front Oncol  2021;11:729228

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