Home / Cyclin-dependent Kinase Inhibitors / NU 6140

NU 6140

Catalog #: 3301
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3301/10
NU 6140 | CAS No. 444723-13-1 | Cyclin-dependent Kinase Inhibitors
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Description: Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

Chemical Name: 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor (IC50 values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC50 value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC50 values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).

Technical Data

M.Wt:
422.52
Formula:
C23H30N6O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
444723-13-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for NU 6140

The citations listed below are publications that use Tocris products. Selected citations for NU 6140 include:

4 Citations: Showing 1 - 4

  1. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.
    Authors: Musa Et al.
    Nat Commun  2019;10:4128
  2. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
    Authors: Berenjeno Et al.
    Nat Commun  2017;8:1773
  3. miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma.
    Authors: Zhang Et al.
    Carcinogenesis  2016;37:858
  4. Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.
    Authors: Boekhout Et al.
    EMBO Rep  2016;17:414

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