NVP 2

Catalog # Availability Size / Price Qty
6535/5
NVP 2 | CAS No. 1263373-43-8 | Cyclin-dependent Kinase Inhibitors
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Description: Potent and selective ATP-competitive CDK9 inhibitor

Chemical Name: 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile

Purity: ≥97%

Product Details
Citations (5)
Reviews

Biological Activity

NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC50 = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC50 = 350 nM), displays <90% binding to CDK7 (IC50 >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.

Technical Data

M.Wt:
513.07
Formula:
C27H37ClN6O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1263373-43-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for NVP 2

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5 Citations: Showing 1 - 5

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