Obatoclax mesylate
Chemical Name: 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Purity: ≥98%
Biological Activity
Obatoclax mesylate is an inhibitor of Bcl-2 family members (IC50 values are 1.11 - 7 μM). Inhibits the interaction of a BH3 domain peptide with 6 members of the Bcl-2 family (Bcl-2, Bcl-XL, Mcl-1, Bcl-W, A1, and Bcl-B) in vitro. Has antiapoptotic and antitumor effects in several tumor bearing mouse models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Nguyen et al.
Proc.Natl.Acad.Sci.U.S.A., 2007;104:19512 -
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins.
Zhai et al.
Cell Death Differ., 2006;13:1419
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