OUL 35

Catalog #: 6344 Datasheet / COA / SDS

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OUL 35 | CAS No. 6336-34-1 | Poly(ADP-ribose) Polymerase Inhibitors

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Description: Selective PARP-10 inhibitor

Chemical Name: 4,4'-Oxybis[benzamide]

Purity: ≥98%

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Biological Activity

OUL 35 is a selective PARP-10 (also known as ADP-ribosyltransferase Diptheria Toxin-like 10, ARTD10) inhibitor (IC₅₀ = 0.329 μM). Displays selectivity for PARP-10 over a panel of PARP family members. Rescues HeLa cells from PARP-10-induced cell death. Sensitizes cancer cells to hydroxyurea-induced genotoxic stress.

Technical Data

M.Wt:

256.26

Formula:

C₁₄H₁₂N₂O₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

6336-34-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage.
Venkannagari et al.
Cell Chem.Biol., 2016;23:1251

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