Oxaliplatin

Catalog #: 2623
7 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
2623/50

Oxaliplatin | CAS No. 61825-94-3 | Apoptosis Inducer Compounds

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Description: DNA cross-linking antitumor agent

Alternative Names: Eloxatin

Chemical Name: Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)

Purity: ≥99%

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Product Details

Citations (7)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Technical Data

M.Wt:

397.29

Formula:

C₈H₁₄N₂O₄Pt

Solubility:

Soluble to 5 mM in water with gentle warming

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

61825-94-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies.
Culy et al.
Drugs, 2000;60:895
Oxaliplatin: a review of evolving concepts.
Mani et al.
Cancer Invest., 2002;20:246
Cellular and molecular pharmacology of oxalip.
Raymond et al.
Mol.Cancer Ther., 2002;1:227

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Citations for Oxaliplatin

The citations listed below are publications that use Tocris products. Selected citations for Oxaliplatin include:

7 Citations: Showing 1 - 7

FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.
Authors: Li Et al.
BMC Cancer 2015;6:9240
Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC.
Authors: Massey
PLoS One 2015;10:e0134306
Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
Authors: Fukushima Et al.
Cancer Sci 2015;106:1000
Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.
Authors: Bryant Et al.
Exp Neurol 2014;14:570
γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments.
Authors: Rawlinson
BMC Cancer 2014;14:483
A high throughput scintillation proximity imaging assay for protein methyltransferases.
Authors: Ibáñez Et al.
Comb Chem High Throughput Screen 2012;15:359
Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by MinCyc.
Authors: Boyette-Davis and Dougherty
Oncotarget 2011;229:353

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