Pam3CSK4
Purity: ≥95%
Biological Activity
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.Technical Data
(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
Offermanns et al.
Biochem.J., 1992;282:551 -
MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.
Caproni et al.
J.Immunol., 2012;188:3088 -
Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells.
St Paul et al.
BMC Res.Notes, 2012;1:616
Product Datasheets
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Citations for Pam3CSK4
The citations listed below are publications that use Tocris products. Selected citations for Pam3CSK4 include:
3 Citations: Showing 1 - 3
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Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
Authors: Valerie G Et al.
Cell Death Differ 2022;29:1267-1282
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Integrative analysis suggests cell type-specific decoding of NF-κB dynamics.
Authors: Alicja Et al.
Sci Signal 2020;13
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Dietary Fiber Pectin Ameliorates Experimental Colitis in a Neutral Sugar Side Chain-Dependent Manner.
Authors: Tomio Et al.
Front Immunol 2020;10:2979
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