Perifosine
Chemical Name: Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate
Purity: ≥99%
Biological Activity
Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.
Fu L, Kim YA, Wang X et al.
Cancer Res -
Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine.
Delgado-Ramírez et al.
Pharmacol Rep., 2016;68:457 -
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells.
Tazzari et al.
Cancer Res., 2008;68:9394
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Citation for Perifosine
The citations listed below are publications that use Tocris products. Selected citations for Perifosine include:
1 Citation: Showing 1 - 1
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Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.
Authors: George Et al.
Cell Rep 2021;35:109168
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