Peroxy Orange 1
Chemical Name: 2',3',6',7'-Tetrahydro-12'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-spiro[isobenzofuran-1(3H),9'-[1H,5H,9H]xantheno[2,3,4-ij]quinolizin]-3-one
Biological Activity
Peroxy Orange 1 is a fluorescent probe for imaging hydrogen peroxide (H2O2); cell permeable. Displays an orange intracellular fluorescence in response to H2O2 signals produced in RAW 264.7 macrophages and A431 cells during immune response and growth factor stimulation, respectively. Excitation wavelength 543 nm, emission between 545 and 750 nm.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells.
Dickinson et al.
J.Am.Chem.Soc., 2010;132:5906 -
Chemistry and biology of reactive oxygen species in signaling or stress responses.
Dickinson et al.
Nat.Chem.Biol., 2011;7:504 -
H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.
Woolley et al.
PLoS ONE, 2012;7
Product Datasheets
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Citations for Peroxy Orange 1
The citations listed below are publications that use Tocris products. Selected citations for Peroxy Orange 1 include:
2 Citations: Showing 1 - 2
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Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux.
Authors: Jeong Et al.
Autophagy 2017;14:120
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A single gene of a commensal microbe affects host susceptibility to enteric infection.
Authors: Young Taek Et al.
Nat Commun 2016;7:11606
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