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Pexacerfont

Catalog #: 6451 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6451/10
6451/50
Pexacerfont | CAS No. 459856-18-9 | CRF1 Receptor Antagonists
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Description: Potent and selective CRF1 antagonist; anxiolytic

Chemical Name: 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine

Purity: ≥98%

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Biological Activity

Pexacerfont is a potent and selective corticotropin-releasing factor 1 receptor (CRF1) antagonist (IC50 = 6.1 nM). Displays >150 fold selectivity for CRF1 over CRF2b. Inhibits CRF-mediated adrenocorticotropic hormone (ACTH) release from pituitary cell culture (IC50 = 129 nM). Displays anxiolytic effects in rat behavioral paradigms.

Technical Data

M.Wt:
340.43
Formula:
C18H24N6O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
459856-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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