PF 05175157
Chemical Name: 1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one
Purity: ≥98%
Biological Activity
PF 05175157 is an potent acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Griffith et al.
J.Med.Chem., 2014;57:10512
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Citation for PF 05175157
The citations listed below are publications that use Tocris products. Selected citations for PF 05175157 include:
1 Citation: Showing 1 - 1
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Low glycaemic diets alter lipid metabolism to influence tumour growth.
Authors: Lien Et al.
Nature 2021;599:302
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