Home / Diacylglycerol O-Acyltransferase (DGAT) Inhibitors / PF 06424439

PF 06424439

Catalog #: 6348
4 Citations Datasheet / COA / SDS
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6348/5
PF 06424439 | CAS No. 1469284-79-4 | Diacylglycerol O-Acyltransferase (DGAT) Inhibitors
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Description: Potent and selective DGAT2 inhibitor

Chemical Name: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 06424439 is a potent and selective DGAT2 inhibitor (IC50 = 14 nM). Exhibits no significant activity at MGAT1-3 or DGAT1. Reduces triglyderide synthesis in human hepatocytes in vitro. Reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Orally bioavailable.

Technical Data

M.Wt:
536.05
Formula:
C22H26ClN7O.CH4O3S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1469284-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citations for PF 06424439

The citations listed below are publications that use Tocris products. Selected citations for PF 06424439 include:

4 Citations: Showing 1 - 4

  1. An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets.
    Authors: Naomi P Et al.
    PLoS Biol  2023;21:e3001977
  2. Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes.
    Authors: Soeren S Et al.
    Elife  2022;11
  3. BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.
    Authors: Kai Et al.
    J Immunol  2021;206:2088-2100
  4. ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway.
    Authors: Jian Et al.
    J Biol Chem  2020;296:100104

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