PIK 90

Catalog # Availability Size / Price Qty
7902/50
7902/10
PIK 90 | CAS No. 677338-12-4 | PI 3-Kinase Inhibitors
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Description: Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

Chemical Name: N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC50 = 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC50 = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo. PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.

Technical Data

M.Wt:
351.36
Formula:
C18H17N5O3
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
677338-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
    Fan et al.
    Cancer cell, 2006;9:341

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