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Pimavanserin

Catalog #: 7667 Datasheet / COA / SDS
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7667/50
Pimavanserin | CAS No. 706779-91-1 | 5-HT2A Receptor Antagonists
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Description: Selective 5-HT2A inverse agonist

Chemical Name: N-[(4-Fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]urea

Purity: ≥98%

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Biological Activity

Pimavanserin (also known as ACP-103) is a selective, potent 5-HT2A receptor inverse agonist (IC50 = 2 nM). Pimavanserin displays ~ 40-fold higher affinity for 5-HT2A over 5-HT2C receptor. Chronic administration of Pimavanserin, suppresses amyloid-β production and improves anxiety-related behavior and memory in Alzheimer's disease mouse models. Pimavanserin shows protective effects on midbrain dopaminergic neurons in a rat model of Parkinson's Disease.

Technical Data

M.Wt:
427.56
Formula:
C25H34FN3O2
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
706779-91-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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