Home / Protein Kinase A Inhibitors / PKI 14-22 amide, myristoylated

PKI 14-22 amide, myristoylated

Catalog #: 2546
16 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2546/1
PKI 14-22 amide, myristoylated
1 Image
Description: Cell-permeable protein kinase A inhibitor
Alternative Names: Protein kinase inhibitor-(14-22)-amide,myristoylated

Purity: ≥95%

Product Details
Citations (16)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data

M.Wt:
1209.5
Formula:
C53H100N20O12
Sequence:
GRTGRRNAI

(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
201422-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase.
    Okumura T, Harada K, Oue K, Zhang J, Asano S, Hayashiuchi M, Mizokami A, Tanaka H, Irifune M, Kamata N, Hirata M, Kanematsu T
    PLoS ONE, 2014;9(6):e100559.
  2. Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro.
    Dalvi PS, Nazarians-Armavil A, Purser MJ, Belsham DD
    Endocrinology, 2012;153(5):2208-22.
  3. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, Muller W
    J Exp Med, 2015;212(7):1021-41.
  4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Wang C, Held R, Hall B
    PLoS ONE, 2013;8(12):e83941.
  5. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
    Singh J, Wen X, Scales S
    J Biol Chem, 2015;290(49):29663-75.
  6. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein.
    Glass et al.
    J.Biol.Chem., 1989;264:8802
  7. Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1.
    Zheng et al.
    J.Biol.Chem., 2000;275:31747
  8. Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A.
    Farrow et al.
    Surgery, 2003;134:197

Product Datasheets

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Citations for PKI 14-22 amide, myristoylated

The citations listed below are publications that use Tocris products. Selected citations for PKI 14-22 amide, myristoylated include:

16 Citations: Showing 1 - 10

  1. Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function.
    Authors: Jakobsen Et al.
    J Neurosci Res  2019;97:1018
  2. The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent.
    Authors: Al-Amily Et al.
    Pflugers Arch  2019;471:633
  3. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
    Authors: Hamnett Et al.
    Nat Commun  2019;10:542
  4. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm.
    Authors: Stival Et al.
    J Biol Chem  2018;293:9435
  5. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
    Authors: Hashimotodani Et al.
    Neuron  2017;95:928
  6. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels.
    Authors: Jantarajit Et al.
    Am J Physiol Cell Physiol  2017;313:C118
  7. The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
    Authors: Singh Et al.
    J Biol Chem  2015;NULL
  8. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
    Authors: Muñoz-Llancao Et al.
    J Exp Med  2015;35:11315
  9. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
    Authors: Watson Et al.
    J Biol Chem  2015;212:1021
  10. Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase.
    Authors: Okumura Et al.
    PLoS One  2014;9:e100559

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