PluriSln 1

Catalog #: 4847 Datasheet / COA / SDS

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PluriSln 1 | CAS No. 91396-88-2 | Compounds for Stem Cell Differentiation

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Description: SCD-1 inhibitor

Alternative Names: NSC 14613

Chemical Name: 4-Pyridinecarboxylic acid 2-phenylhydrazide

Purity: ≥99%

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Biological Activity

PluriSln 1 is a stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.

Technical Data

M.Wt:

213.24

Formula:

C₁₂H₁₁N₃O

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

91396-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen.
Ben-David et al.
Cell Stem Cell, 2013;12:167

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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