PNU 282987
Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
Purity: ≥98%
Biological Activity
PNU 282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors.
Bodnar et al.
J.Med.Chem., 2005;48:905 -
The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthe
Haj?s et al.
J.Pharmacol.Exp.Ther., 2005;312:1213
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Citations for PNU 282987
The citations listed below are publications that use Tocris products. Selected citations for PNU 282987 include:
3 Citations: Showing 1 - 3
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Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
Authors: Zhong Et al.
Elife 2013;8:e82719
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Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist.
Authors: Pandya and Yakel
Neuropharmacology 2013;70:35
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Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Authors: Wang Et al.
J Neurosci 2012;32:9773
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