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Poly(ADP-ribose) Polymer/pADPr

Catalog #: 4336-100-01
11 Citations Datasheet / COA / SDS
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4336-100-01
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Citations (11)
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Summary Product Datasheets Background

Poly(ADP-ribose) Polymer/pADPr Summary

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -80 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Product Datasheets

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Background: PAR/pADPr

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Long Name
Poly [ADP-ribose] Polymer
Alternate Names
pADPr; PAR; Poly(ADP-ribose)

Citations for Poly(ADP-ribose) Polymer/pADPr

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
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  1. A mechanism for oxidative damage repair at gene regulatory elements
    Authors: S Ray, AA Abugable, J Parker, K Liversidge, NM Palminha, C Liao, AE Acosta-Mar, CDS Souza, M Jurga, I Sudbery, SF El-Khamisy
    Nature, 2022-09-28;609(7929):1038-1047.  2022-09-28
  2. BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
    Authors: Y Zhang, M Fang, S Li, H Xu, J Ren, L Tu, B Zuo, W Yao, G Liang
    Molecular Cancer, 2022-08-02;21(1):158.  2022-08-02
  3. PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair
    Authors: B Peng, R Shi, J Bian, Y Li, P Wang, H Wang, J Liao, WG Zhu, X Xu
    Nucleic Acids Research, 2021-07-21;49(13):7554-7570.  2021-07-21
  4. RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3&alpha Co-localization
    Authors: J Wang, YT Oh, Z Li, J Dou, S Tang, X Wang, H Wang, S Takeda, Y Wang
    Cell Reports, 2021-01-12;34(2):108625.  2021-01-12
  5. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
    Authors: M Gatti, R Imhof, Q Huang, M Baudis, M Altmeyer
    Cell Rep, 2020-08-04;32(5):107985.  2020-08-04
  6. Genetically Encoded Fluorescent Sensor for Poly-ADP-Ribose
    Authors: EO Serebrovsk, NM Podvalnaya, VV Dudenkova, AS Efremova, NG Gurskaya, DA Gorbachev, AV Luzhin, OL Kantidze, EV Zagaynova, SI Shram, KA Lukyanov
    Int J Mol Sci, 2020-07-15;21(14):.  2020-07-15
  7. Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation
    Authors: AKL Leung
    Trends Cell Biol., 2020-02-20;30(5):370-383.  2020-02-20
  8. PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA
    Authors: AS Singatulin, L Hamon, MV Sukhanova, B Desforges, V Joshi, A Bouhss, OI Lavrik, D Pastré
    Cell Rep, 2019-05-07;27(6):1809-1821.e5.  2019-05-07
  9. How the location of superoxide generation influences the beta-cell response to nitric oxide.
    Authors: Broniowska K, Oleson B, McGraw J, Naatz A, Mathews C, Corbett J
    J Biol Chem, 2015-02-03;290(12):7952-60.  2015-02-03
  10. DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal.
    Authors: Britton S, Dernoncourt E, Delteil C, Froment C, Schiltz O, Salles B, Frit P, Calsou P
    Nucleic Acids Res, 2014-07-16;42(14):9047-62.  2014-07-16
  11. PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
    Authors: Rulten S, Rotheray A, Green R, Grundy G, Moore D, Gomez-Herreros F, Hafezparast M, Caldecott K
    Nucleic Acids Res, 2013-09-18;42(1):307-14.  2013-09-18

FAQs

  1. What is the concentration of this polymer in units of mass/volume?

    • The concentration of poly(ADP-ribose) Polymer/pADPr is determined by measuring light absorbance at 258 nm using the molar extinction coefficient of PAR. This measurement yields concentration in units of μM. The chain length of this polymer ranges between 2 and 300 ADP-ribose units. Because we are unable to evaluate the variation in polymer length and polymer branching, we are unable to calculate a concentration based on mass. As such, this product is bottled and sold by the concentration in molarity.

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