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PRIMA-1

Catalog #: 1862
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1862/10
1862/50
PRIMA-1 | CAS No. 5608-24-2 | Additional p53-related Compounds
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Description: Restores mutant p53 activity; induces apoptosis

Chemical Name: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.

Technical Data

M.Wt:
185.22
Formula:
C9H15NO3
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
5608-24-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PRIMA-1

The citations listed below are publications that use Tocris products. Selected citations for PRIMA-1 include:

3 Citations: Showing 1 - 3

  1. An inverse docking approach for identifying new potential anti-cancer targets.
    Authors: Grinter Et al.
    J Neurosci  2011;29:795
  2. Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study.
    Authors: Benakanakere Et al.
    Endocr Relat Cancer  2009;16:85
  3. Sequential transcription factor targeting for diffuse large B-cell lymphomas.
    Authors: Cerchietti Et al.
    Cancer Res  2008;68:3361

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