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QAQ dichloride

Catalog #: 5470
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5470/10
5470/50
QAQ dichloride | Non-selective Cav Blockers
1 Image
Description: Photoswitchable Nav, Kv and Cav channel blocker

Chemical Name: 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

QAQ dichloride is a photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.

Technical Data

M.Wt:
567.59
Formula:
C28H44Cl2N6O2
Solubility:
Soluble to 50 mM in water
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Photochromic blockers of voltage-gated potassium channels.
    Banghart MR et al.
    Angew.Chem.Int.Ed., 2009;48:9097
  2. Rapid optical control of nociception with an ion-channel photoswitch.
    Mourot et al.
    Nat.Methods, 2012;9:396

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for QAQ dichloride

The citations listed below are publications that use Tocris products. Selected citations for QAQ dichloride include:

2 Citations: Showing 1 - 2

  1. Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors.
    Authors: Nikolaev Et al.
    Eur.J.Pharmacol.  2022;938:175448

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