(R)-2-Hydroxyglutaric acid disodium salt
Chemical Name: (R)-2-Hydroxypentanedioic acid disodium salt
Biological Activity
(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
Carbonneau M, M Gagne L, Lalonde ME et al.
Nat Commun -
FTO controls reversible m6Am RNA methylation during snRNA biogenesis.
Mauer et al.
Nat.Chem.Biol., 2019;15:340 -
The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.
Chen et al.
Sci.Rep., 2016;6:32428
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