Home / Bradykinin Receptor Antagonists / R 715

R 715

Catalog #: 3407
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3407/1
R 715
1 Image
Description: Potent and selective B1 antagonist

Purity: ≥95%

Product Details
Citations (6)
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Biological Activity

R 715 is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.

Technical Data

M.Wt:
1140.35
Formula:
C57H81N13O12
Sequence:
KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, X = DβNal)

Solubility:
Soluble to 5 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
185052-09-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for R 715

The citations listed below are publications that use Tocris products. Selected citations for R 715 include:

6 Citations: Showing 1 - 6

  1. Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus.
    Authors: Brailoiu
    Neuroscience  2017;365:23
  2. A role for bradykinin signaling in chronic vulvar pain.
    Authors: Falsetta Et al.
    The Journal of Pain  2016;
  3. Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.
    Authors: Kawaguchi Et al.
    J Cereb Blood Flow Metab  2015;9:229
  4. Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4.
    Authors: Xu Et al.
    Am J Respir Cell Mol Biol  2014;51:370
  5. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal  2013;11:70
  6. Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.
    Authors: Albert-Weissenberger Et al.
    EMBO Mol Med  2012;32:1747

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