rac BHFF
Chemical Name: 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Purity: ≥98%
Biological Activity
rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
Koek et al.
J.Pharmacol.Exp.Ther., 2013;344:553 -
Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors.
Malherbe et al.
Br.J.Pharmacol., 2008;154:797
Product Datasheets
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Citation for rac BHFF
The citations listed below are publications that use Tocris products. Selected citations for rac BHFF include:
1 Citation: Showing 1 - 1
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GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Authors: Zhang Et al.
Clin Exp Dermatol 2015;5:10468
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