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Rat IL-6 ELISA Kit - Quantikine

Catalog #: R6000B
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Summary Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Rat IL-6 Quantikine ELISA Kit Summary

Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL)
Sensitivity
36 pg/mL
Assay Range
62.5 - 4,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma)
Specificity
Natural and recombinant rat IL-6
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Rat IL-6 Immunoassay is a 4.5 hour solid phase ELISA designed to measure rat IL-6 in cell culture supernates, rat serum, and plasma. It contains E. coli-expressed recombinant rat IL-6 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant protein. Results obtained using natural rat IL-6 showed dose-response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural rat IL-6.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 22 27 28
Mean (pg/mL) 120 256 1028 134 268 987
Standard Deviation 10.6 22.4 46.2 13.4 21.7 69.2
CV% 8.8 8.8 4.5 10 8.1 7

Recovery

The recovery of rat IL-6 spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=5) 103 85-118
EDTA Plasma (n=5) 96 81-111
Serum (n=5) 97 91-105

Linearity

To assess the linearity of the assay, five or more samples containing and/or spiked with various concentrations of rat IL-6 in each matrix were diluted with Calibrator Diluent and then assayed.
Rat IL-6 ELISA Linearity

Scientific Data

N/A Rat IL-6 ELISA Standard Curve View Larger

Rat IL-6 ELISA Standard Curve

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-6

Interleukin 6 (IL-6) is a multifunctional cytokine that plays important roles in host defense, acute phase reactions, immune responses, nerve cell functions and hematopoiesis (1-5). It is expressed by a variety of normal and transformed lymphoid and non-lymphoid cells. The production of IL-6 is up-regulated by numerous signals such as mitogenic or antigenic stimulation, lipopolysaccharides, calcium ionophores, cytokines and viruses. IL-4, IL-10 and IL-13 inhibit IL-6 expression in monocytes. Elevated serum IL-6 levels have been observed in a number of pathological conditions, including bacterial and viral infections, trauma, autoimmune diseases, inflammations and malignancies (1-5). 

IL-6 is a prototypic member of the IL-6 superfamily of cytokines that share gp130 as a component required for signal transduction (4). The rat, mouse and human IL-6 cDNAs have been cloned (6-9). Rat IL-6 cDNA encodes a 211 amino acid (aa) residue precursor polypeptide with a hydrophobic signal peptide that is cleaved to generate the 187 aa residue mature protein. At the protein sequence level, there is approximately 39% identity between rat and human, and 87% identity between mouse and rat IL-6 (6). Although human and mouse IL-6 are equally active on mouse cells, mouse IL-6 is not active on human cells (9). 
The high-affinity IL-6 receptor complex, which mediates IL-6 bioactivity, consists of two membrane glycoproteins: an 80 kDa low-affinity IL-6-binding receptor (IL-6 R) and a 130 kDa signal-transducing protein (gp130) that lacks IL-6 binding ability (4). The binding of IL-6 to IL-6 R recruits gp130 to form a trimeric complex that dimerizes to form a hexameric complex, which transduces IL-6 signal (4). Soluble forms of both IL-6 R and gp130 have been detected in blood (11, 12). Soluble IL-6 R is capable of binding IL-6 and inducing homodimerization of membrane gp130 and subsequent signal transduction.

Long Name:
Interleukin 6
Entrez Gene IDs:
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 102138971 (Cynomolgus Monkey); 100034196 (Equine); 493687 (Feline); 463288 (Primate); 100008733 (Rabbit)
Alternate Names:
B-cell differentiation factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CTL differentiation factor ; HSF; hybridoma growth factor; IFNB2; IFN-beta-2; IL6; IL-6; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Citations for Rat IL-6 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

170 Citations: Showing 1 - 10
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  1. Eriodictyol attenuates doxorubicin-induced nephropathy by activating the AMPK/Nrf2 signalling pathway
    Authors: Badi, RM;Khaleel, EF;Satti, HH;Monir, R;
    Journal of traditional and complementary medicine
    Species: S. agalactiae
    Sample Types: Tissue Homogenates
  2. Natural antioxidant formula ameliorates lipopolysaccharide-induced impairment of hippocampal neurogenesis and contextual fear memory through suppression of neuroinflammation in rats
    Authors: Zeng, W;Takashima, K;Tang, Q;Zou, X;Ojiro, R;Ozawa, S;Jin, M;Ando, Y;Yoshida, T;Shibutani, M;
    Journal of chemical neuroanatomy
    Species: Rat
    Sample Types: Tissue Homogenates
  3. Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats
    Authors: J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang
    Heliyon, 2023-04-11;9(4):e15333.
    Species: Rat
    Sample Types: Tissue Homogenates
  4. Protective Effect of Oxygen and Isoflurane in Rodent Model of Intestinal Ischemia-Reperfusion Injury
    Authors: M Clarysse, A Accarie, R Farré, E Canovai, D Monbaliu, J Gunst, G De Hertogh, T Vanuytsel, J Pirenne, LJ Ceulemans
    International Journal of Molecular Sciences, 2023-01-30;24(3):.
    Species: Rat
    Sample Types: Plasma
  5. Supplementation with okra�combined or not with exercise training is able to protect the heart of animals with metabolic syndrome
    Authors: MFP Gomes, EOC de Moura, NM Cardoso, GA da Silva, ACC Dos Santos, FS de Souza, D Estadella, RH Lambertucc, JHG Lago, A Medeiros
    Scientific Reports, 2023-01-26;13(1):1468.
    Species: Rat
    Sample Types: Tissue Homogenates
  6. Protective Effect of Oxygen and Isoflurane in Rodent Model of Intestinal Ischemia-Reperfusion Injury
    Authors: M Clarysse, A Accarie, R Farré, E Canovai, D Monbaliu, J Gunst, G De Hertogh, T Vanuytsel, J Pirenne, LJ Ceulemans
    International Journal of Molecular Sciences, 2023;24(3):.
    Species: Rat
    Sample Types: Plasma
  7. Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats
    Authors: J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang
    Heliyon, 2023;9(4):e15333.
    Species: Rat
    Sample Types: Tissue Homogenates
  8. The Synergistic Protective Effect of gamma-Oryzanol (OZ) and N-Acetylcysteine (NAC) against Experimentally Induced NAFLD in Rats Entails Hypoglycemic, Antioxidant, and PPARalpha Stimulatory Effects
    Authors: AH Alwadani, SA Almasri, AA Aloud, NA Albadr, GM Alshammari, MA Yahya
    Nutrients, 2022-12-26;15(1):.
    Species: Rat
    Sample Types: Tissue Homogenates
  9. Acute postoperative pain and dorsal root ganglia transcriptomic signatures following total knee arthroplasty (TKA) in rats: An experimental study
    Authors: DE Komatsu, SMZ Uddin, C Gordon, MP Kanjiya, D Bogdan, J Achonu, A DiBua, H Iftikhar, A Ackermann, RJ Shah, J Shieh, AB Bialkowska, M Kaczocha
    PLoS ONE, 2022-12-06;17(12):e0278632.
    Species: Rat
    Sample Types: Serum
  10. A Comparative Study of Two Models of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Long-Lasting Accumulation of Corticosterone and Interleukins in the Hippocampus and Frontal Cortex in Koizumi Model
    Authors: MV Onufriev, MY Stepaniche, YV Moiseeva, MY Zhanina, OA Nedogreeva, PA Kostryukov, NA Lazareva, NV Gulyaeva
    Biomedicines, 2022-12-02;10(12):.
    Species: Rat
    Sample Types: Serum
  11. Modulation Effects of Eugenol on Nephrotoxicity Triggered by Silver Nanoparticles in Adult Rats
    Authors: HR Aboelwafa, RA Ramadan, SS Ibraheim, HN Yousef
    Biology, 2022-11-27;11(12):.
    Species: Rat
    Sample Types: Tissue Homogenates
  12. Targeting caveolae to pump bispecific antibody to TGF-beta into diseased lungs enables ultra-low dose therapeutic efficacy
    Authors: AH Kadam, K Kandasamy, T Buss, B Cederstrom, C Yang, S Narayanapi, J Rodriguez, MD Levin, J Koziol, B Olenyuk, Z Borok, A Chrastina, JE Schnitzer
    PLoS ONE, 2022-11-22;17(11):e0276462.
    Species: Rat
    Sample Types: BALF
  13. Anti-Inflammatory Protein Isolated from Tamarind Promotes Better Histological Aspects in the Intestine Regardless of the Improvement of Intestinal Permeability in a Preclinical Study of Diet-Induced Obesity
    Authors: MSR Lima, C Gonçalves, MD Neto, MH Macedo, JLC Queiroz, VC da Silva, IS Costa, CDS Camillo, PPA Santos, AAM Lima, L Pastrana, BLL Maciel, AHA Morais
    Nutrients, 2022-11-04;14(21):.
    Species: Rat
    Sample Types: Plasma
  14. MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide
    Authors: J Wang, Z Ye, Y Chen, X Qiao, Y Jin
    Scientific Reports, 2022-10-26;12(1):17915.
    Species: Rat
    Sample Types: Plasma
  15. DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model
    Authors: C Liao, H Zhou, H Chen, G Cheng, S Li, F Ma, X Yang, B Xie, W Zhang
    International immunopharmacology, 2022-10-21;113(0):109284.
    Species: Rat
    Sample Types: Cell Culture Supernates
  16. The Ameliorative Role of Eugenol against Silver Nanoparticles-Induced Hepatotoxicity in Male Wistar Rats
    Authors: HN Yousef, SS Ibraheim, RA Ramadan, HR Aboelwafa
    Oxidative Medicine and Cellular Longevity, 2022-09-10;2022(0):3820848.
    Species: Rat
    Sample Types: Tissue Homogenates
  17. Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways
    Authors: T Khamis, AE Alsemeh, DM Abdullah
    Scientific Reports, 2022-08-27;12(1):14654.
    Species: Rat
    Sample Types: Serum
  18. Rhabdomyolysis-induced acute kidney injury and concomitant apoptosis induction via ROS-mediated ER stress is efficaciously counteracted by epigallocatechin gallate
    Authors: SN Chang, M Haroon, DK Dey, SC Kang
    The Journal of nutritional biochemistry, 2022-08-24;0(0):109134.
    Species: Rat
    Sample Types: Tissue Homogenates
  19. Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor
    Authors: B Chen, G Qin, J Xiao, X Deng, A Lin, H Liu
    Journal of Neuroinflammation, 2022-07-13;19(1):181.
    Species: Rat
    Sample Types: Serum
  20. N-3 PUFA Ameliorates the Gut Microbiota, Bile Acid Profiles, and Neuropsychiatric Behaviours in a Rat Model of Geriatric Depression
    Authors: TH Tung, YC Chen, YT Lin, SY Huang
    Biomedicines, 2022-07-04;10(7):.
    Species: Rat
    Sample Types: Plasma
  21. Fenugreek Seed Galactomannan Aqueous and Extract Protects against Diabetic Nephropathy and Liver Damage by Targeting NF-kappaB and Keap1/Nrf2 Axis
    Authors: SM Alsuliam, NA Albadr, SA Almaiman, AS Al-Khalifa, NS Alkhaldy, GM Alshammari
    Toxics, 2022-06-30;10(7):.
    Species: Rat
    Sample Types: Tissue Homogenates
  22. Serial Change of Endotoxin Tolerance in a Polymicrobial Sepsis Model
    Authors: MJ Lee, J Bae, JH Lee, YJ Park, HAR Lee, S Mun, YS Kim, CJ Yune, TN Chung, K Kim
    International Journal of Molecular Sciences, 2022-06-13;23(12):.
    Species: Rat
    Sample Types: Plasma
  23. Carbocisteine as a Modulator of Nrf2/HO-1 and NFkappaB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis
    Authors: AM Abdelhamid, ME Youssef, S Cavalu, G Mostafa-He, A Youssef, ST Elazab, S Ibrahim, S Allam, RM Elgharabaw, E El-Ahwany, NA Amin, A Shata, OA Mohammed, MS Ibrahim Ab, A Alhowail, G El-Saber B, EA El-Mahmoud, M Attia, A Allam, MY Zaater, MM Osman, M Nader, A Taha, NA Makarem, S Saber
    Oncogene, 2022-06-08;13(0):887233.
    Species: Rat
    Sample Types: Tissue Homogenates
  24. Neuroprotective Effect of Bcl-2 on Lipopolysaccharide-Induced Neuroinflammation in Cortical Neural Stem Cells
    Authors: SY Park, JS Han
    International Journal of Molecular Sciences, 2022-06-07;23(12):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  25. Aerobic exercise training combined or not with okra consumption as a strategy to prevent kidney changes caused by metabolic syndrome in Zucker rats
    Authors: MM da Silva, MFP Gomes, EOC de Moura, MM Veras, MC Kubota, AP Takano, ACC Dos Santos, CGDR José, GADS Souza, NM Cardoso, D Estadella, RH Lambertucc, A Medeiros
    PLoS ONE, 2022-06-03;17(6):e0269418.
    Species: Rat
    Sample Types: Tissue Homogenates
  26. Impact of shear wave dispersion slope analysis for assessing the severity of myocarditis
    Authors: N Amioka, Y Takaya, K Nakamura, M Kondo, K Akazawa, Y Ohno, K Ichikawa, R Nakayama, Y Saito, S Akagi, T Miyoshi, M Yoshida, H Morita, H Ito
    Scientific Reports, 2022-05-24;12(1):8776.
    Species: Rat
    Sample Types: Serum
  27. Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats
    Authors: C Peyronnel, P Totoson, V Petitcolin, F Bonnefoy, X Guillot, P Saas, F Verhoeven, H Martin, C Demougeot
    Arthritis Research & Therapy, 2022-04-29;24(1):97.
    Species: Rat
    Sample Types: Plasma
  28. Neonatal Immune Challenge influences the Microbiota and Behaviour in a Sexually Dimorphic Manner
    Authors: A Cuskelly, EC Hoedt, L Harms, NJ Talley, MA Tadros, S Keely, DM Hodgson
    Brain, Behavior, and Immunity, 2022-04-28;103(0):232-242.
    Species: Rat
    Sample Types: Plasma
  29. H3K9me2 regulation of BDNF expression via G9a partakes in the progression of heart failure
    Authors: F Yan, Z Chen, W Cui
    BMC cardiovascular disorders, 2022-04-19;22(1):182.
    Species: Rat
    Sample Types: Serum
  30. Development of a Rat Model of Intra-Amniotic Inflammation via Ultrasound-Guided Administration of a Triggering Agent in the Gestational Sac to Enable Analysis of Individual Amniotic Fluid Samples
    Authors: J Stranik, M Kacerovsky, M Sterba, C Andrys, C Abad, F Staud, S Micuda, O Soucek, B Jacobsson, I Musilova
    Frontiers in Pharmacology, 2022-04-12;13(0):871193.
    Species: Rat
    Sample Types: Amniotic Fluid
  31. PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression
    Authors: Y Bai, Q Han, B Dong, H Lin, Y Jiang, X Zhang, H Chen, Y Yu
    Brain research bulletin, 2022-03-30;184(0):56-67.
    Species: Mouse
    Sample Types: Tissue Homogenates
  32. Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis?fibroblast?like synoviocytes by inhibiting the NF?kappaB and MAPK signaling pathways
    Authors: X Gao, X Kang, H Lu, E Xue, R Chen, J Pan, J Ma
    Molecular Medicine Reports, 2022-03-24;25(5):.
    Species: Rat
    Sample Types: Serum
  33. Vitamin C Improves the Outcomes of Cardiopulmonary Resuscitation and Alters Shedding of Syndecan-1 and p38/MAPK Phosphorylation in a Rat Model
    Authors: Y Xiao, C Su, G Zhang, L Liang, T Jin, J Bradley, JP Ornato, W Tang
    Journal of the American Heart Association, 2022-03-15;0(0):e023787.
    Species: Rat
    Sample Types: Serum
  34. Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1alpha and JAK2/STAT3 signaling pathway in rats
    Authors: MS El-Ghannam, MA Saad, NN Nassar, MF El-Yamany, AAZ El-Bahy
    Toxicology and Applied Pharmacology, 2022-02-03;438(0):115906.
    Species: Rat
    Sample Types: Tissue Homogenates
  35. Loss of the Protective Effect of Estrogen Contributes to Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization Elicited by Postweaning High-Fat Diet in Female Offspring
    Authors: B Xue, Y Yu, TG Beltz, F Guo, SG Wei, AK Johnson
    Journal of the American Heart Association, 2022-01-11;11(2):e023685.
    Species: Rat
    Sample Types: Plasma
  36. Real-Time Brain Monitoring by Near-Infrared Spectroscopy Predicts Neurological Outcome after Cardiac Arrest and Resuscitation in Rats: A Proof of Concept Study of a Novel Prognostic Measure after Cardiac Arrest
    Authors: R Takegawa, K Hayashida, T Yin, RC Choudhary, SJ Miyara, H Khalili, M Shoaib, Y Endo, EP Molmenti, LB Becker
    Journal of Clinical Medicine, 2021-12-27;11(1):.
    Species: Rat
    Sample Types: Plasma
  37. A Comparative Study of Koizumi and Longa Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Early Corticosterone and Inflammatory Response in the Hippocampus and Frontal Cortex
    Authors: MV Onufriev, YV Moiseeva, MY Zhanina, NA Lazareva, NV Gulyaeva
    International Journal of Molecular Sciences, 2021-12-17;22(24):.
    Species: Rat
    Sample Types: Serum
  38. Protective effects of endothelial progenitor cell microvesicles on Ang�II?induced rat kidney cell injury
    Authors: Y Song, Z Bai, Y Zhang, J Chen, M Chen, Y Zhang, X Zhang, H Mai, B Wang, Y Lin, S Gu
    Molecular Medicine Reports, 2021-11-05;25(1):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  39. Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP)
    Authors: B Sun, Z Chen, Q Chi, Y Zhang, B Gao
    Journal of Cellular and Molecular Medicine, 2021-10-13;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  40. Maternal Angiotensin II-Induced Hypertension Sensitizes Postweaning High-Fat Diet-Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring
    Authors: B Xue, Y Yu, TG Beltz, F Guo, RB Felder, SG Wei, A Kim Johnso
    Journal of the American Heart Association, 2021-09-06;0(0):e022170.
    Species: Rat
    Sample Types: Plasma
  41. Acute myocardial injury secondary to severe acute liver failure: A retrospective analysis supported by animal data
    Authors: M Uhlig, M Hein, MA Habigt, RH Tolba, T Braunschwe, MJ Helmedag, U Klinge, A Koch, C Trautwein, M Mechelinck
    PLoS ONE, 2021-08-30;16(8):e0256790.
    Species: Rat
    Sample Types: Plasma
  42. Acute Inflammatory Response in Osteoporotic Fracture Healing Augmented with Mechanical Stimulation is Regulated In Vivo through the p38-MAPK Pathway
    Authors: SKH Chow, C Cui, KYK Cheng, YN Chim, J Wang, CHW Wong, KW Ng, RMY Wong, WH Cheung
    International Journal of Molecular Sciences, 2021-08-13;22(16):.
    Species: Rat
    Sample Types: Serum
  43. L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus
    Authors: N Ayuob, SA Shaker, E Hawuit, NS Al-Abbas, NA Shaer, S Al Jaouni, MR Mahdi
    Oxidative Medicine and Cellular Longevity, 2021-07-10;2021(0):6662649.
    Species: Rat
    Sample Types: Serum
  44. Can selenium-enriched spirulina supplementation ameliorate sepsis outcomes in selenium-deficient animals?
    Authors: T Castel, M Theron, K Pichavant-, A Guernec, A Joublin-De, B Gueguen, K Leon
    Physiological Reports, 2021-07-01;9(14):e14933.
    Species: Rat
    Sample Types: Plasma
  45. Prenatal Hyperhomocysteinemia Induces Glial Activation and Alters Neuroinflammatory Marker Expression in Infant Rat Hippocampus
    Authors: AD Shcherbits, DS Vasilev, YP Milyutina, NL Tumanova, AV Mikhel, IV Zalozniaia, AV Arutjunyan
    Cells, 2021-06-18;10(6):.
    Species: Rat
    Sample Types: Tissue Homogenates
  46. Melatonin Alleviated Potassium Dichromate-Induced Oxidative Stress and Reprotoxicity in Male Rats
    Authors: SAE Bashandy, H Ebaid, J Al-Tamimi, OA Ahmed-Fari, EA Omara, IM Alhazza
    BioMed Research International, 2021-06-15;2021(0):3565360.
    Species: Rat
    Sample Types: Plasma
  47. Down-regulation of SNHG16 alleviates the acute lung injury in sepsis rats through miR-128-3p/HMGB3 axis
    Authors: J Sun, K Xin, C Leng, J Ge
    BMC pulmonary medicine, 2021-06-06;21(1):191.
    Species: Rat
    Sample Types: Tissue Homogenates
  48. Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-&kappaB signaling pathway
    Authors: H Gao, H Ma, M Gao, A Chen, S Zha, J Yan
    Bioscience Reports, 2021-04-30;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  49. A novel rat model of chronic subdural hematoma: Induction of inflammation and angiogenesis in the subdural space mimicking human-like features of progressively expanding hematoma
    Authors: X Xu, D Wang, Z Han, B Wang, W Gao, Y Fan, F Li, Z Zhou, C Gao, J Xiong, S Zhou, S Zhang, G Yang, R Jiang, J Zhang
    Brain research bulletin, 2021-04-28;172(0):108-119.
    Species: Rat
    Sample Types: Tissue Homogenates
  50. Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients
    Authors: I Belinchón-, P Bellot, D Romero-Pér, I Herraiz-Ro, F Marco, R Frances, JM Ramos-Rinc
    Scientific Reports, 2021-04-21;11(1):8593.
    Species: Rat
    Sample Types: Serum
  51. Phgdh serves a protective role in Il?1&beta induced chondrocyte inflammation and oxidative?stress damage
    Authors: H Huang, K Liu, H Ou, X Qian, J Wan
    Molecular Medicine Reports, 2021-04-13;23(6):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  52. Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats
    Authors: EK Jackson, Z Mi, DG Gillespie, D Cheng, SP Tofovic
    Journal of the American Heart Association, 2021-03-08;10(6):e020088.
    Species: Rat
    Sample Types: Plasma
  53. Vagus nerve stimulation ameliorates L-NAME-induced preeclampsia-like symptoms in rats through inhibition of the inflammatory response
    Authors: L Zheng, R Tang, L Shi, M Zhong, Z Zhou
    BMC pregnancy and childbirth, 2021-03-04;21(1):177.
    Species: Rat
    Sample Types: Serum
  54. The Need of Enterococcal Coverage in Severe Intra-Abdominal Infection: Evidence from Animal Study
    Authors: MJ Lee, TN Chung, YJP B, HAR Lee, JH Lee, CJ Yune, J Bae, S Mun, JS Park, K Kim
    Journal of Clinical Medicine, 2021-03-02;10(5):.
    Species: Rat
    Sample Types: Plasma
  55. Antioxidative Capacity of Liver- and Adipose-Derived Mesenchymal Stem Cell-Conditioned Media and Their Applicability in Treatment of Type 2 Diabetic Rats
    Authors: MM Elshemy, M Asem, KS Allemailem, K Uto, M Ebara, A Nabil
    Oxidative Medicine and Cellular Longevity, 2021-02-02;2021(0):8833467.
    Species: Rat
    Sample Types: Serum
  56. Docosahexaenoic fatty acid reduces the pro-inflammatory response induced by IL-1&beta in astrocytes through inhibition of NF-&kappaB and AP-1 transcription factor activation
    Authors: E Zgórzy?ska, D Stulczewsk, B Dziedzic, KP Su, A Walczewska
    Bmc Neuroscience, 2021-01-27;22(1):4.
    Species: Rat
    Sample Types: Cell Culture Supernates
  57. Central Administration of Angiotensin-(1-7) Improves Vasopressin Impairment and Hypotensive Response in Experimental Endotoxemia
    Authors: P Passaglia, F de Lima Fa, ME Batalhão, AM Stabile, LM Bendhack, J Antunes-Ro, R Lacchini, E Capellari
    Cells, 2021-01-08;10(1):.
    Species: Rat
    Sample Types: Serum
  58. Isoflurane reduces septic neuron injury by HO?1?mediated abatement of inflammation and apoptosis
    Authors: L Zhang, X Zhang, T Wu, X Pan, Z Wang
    Molecular Medicine Reports, 2020-12-23;23(2):.
    Species: Mouse
    Sample Types: Serum
  59. Sex Differences in Vagus Nerve Stimulation Effects on Rat Cardiovascular and Immune Systems
    Authors: F Yaghouby, K Jang, U Hoang, S Asgari, S Vasudevan
    Front Neurosci, 2020-11-06;14(0):560668.
    Species: Rat
    Sample Types: Plasma
  60. SNHG16 aggravates chronic constriction injury-induced neuropathic pain in rats via binding with miR-124-3p and miR-141-3p to upregulate JAG1
    Authors: H Li, L Fan, Y Zhang, Y Cao, X Liu
    Brain Res Bull, 2020-10-10;165(0):228-237.
    Species: Rat
    Sample Types: Cell Culture Supernates
  61. Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways
    Authors: L Jia, K Xue, J Liu, OA Habotta, L Hu, AE Abdel Mone
    Mediators Inflamm, 2020-09-29;2020(0):9419085.
    Species: Rat
    Sample Types: Cell Culture Supernates
  62. Ascorbic acid deficiency induces hepatic and intestinal expression of inflammation-related genes irrespective of the presence or absence of gut microbiota in ODS rats
    Authors: N Kawade, A Murai, W Suzuki, K Takeuchi, M Kondo, M Kobayashi, F Horio
    J. Nutr. Biochem., 2020-08-20;0(0):108485.
    Species: Rat
    Sample Types: Serum
  63. Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway
    Authors: C Huang, W Zhang, A Sun, X Zhang, J Guo, R Ji, L Qiao, X Sun, D Zhao
    Oxid Med Cell Longev, 2020-08-18;2020(0):7075836.
    Species: Rat
    Sample Types: Plasma
  64. N?acetyl cysteine inhibits the lipopolysaccharide?induced inflammatory response in bone marrow mesenchymal stem cells by suppressing the TXNIP/NLRP3/IL?1&beta signaling pathway
    Authors: X Wang, M Jiang, X He, B Zhang, W Peng, L Guo
    Molecular Medicine Reports, 2020-08-13;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  65. Inhibitor of RAGE and glucose?induced inflammation in bone marrow mesenchymal stem cells: Effect and mechanism of action
    Authors: M Jiang, X Wang, P Wang, W Peng, B Zhang, L Guo
    Molecular Medicine Reports, 2020-08-07;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  66. Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide?induced acute pneumonia in rats
    Authors: X Wang
    Molecular Medicine Reports, 2020-08-04;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  67. Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF?1&alpha and apoptosis
    Authors: W Sun, A Li, Z Wang, X Sun, M Dong, F Qi, L Wang, Y Zhang, P Du
    Molecular Medicine Reports, 2020-07-28;0(0):.
    Species: Rat
    Sample Types: Serum
  68. Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock?resuscitation?induced acute lung injury through inhibiting the NLRP3 inflammasome
    Authors: T Ming, M Yuan, Q Kong, Q Huang, Z Xia, X Wu
    Mol Med Rep, 2020-07-10;22(3):2507-2515.
    Species: Rat
    Sample Types: Serum
  69. Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients
    Authors: N Casanova-V, D Constantin, A Filer, RS Hardy, PL Greenhaff, V Chapman
    PLoS ONE, 2020-07-07;15(7):e0235702.
    Species: Rat
    Sample Types: Plasma
  70. Xanthan gum protects temporomandibular chondrocytes from IL?1&beta through Pin1/NF?&kappaB signaling pathway
    Authors: F Yuan, JL Xie, KY Liu, JL Shan, YG Sun, WG Ying
    Mol Med Rep, 2020-06-15;22(2):1129-1136.
    Species: Rat
    Sample Types: Cell Culture Supernates
  71. Comparison of the effect of membrane sizes and fibre arrangements of two membrane oxygenators on the inflammatory response, oxygenation and decarboxylation in a rat model of extracorporeal membrane oxygenation
    Authors: F Edinger, E Schneck, C Schulte, J Gehron, S Mueller, M Sander, C Koch
    BMC Cardiovasc Disord, 2020-06-15;20(1):294.
    Species: Rat
    Sample Types: Plasma
  72. Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis
    Authors: O Ameen, RI Yassien, YM Naguib
    BMC Musculoskelet Disord, 2020-06-12;21(1):375.
    Species: Rat
    Sample Types: Serum
  73. Long non-coding RNA ANRIL knockdown suppresses apoptosis and pro-inflammatory cytokines while enhancing neurite outgrowth via binding microRNA-125a in a cellular model of Alzheimer's disease
    Authors: B Zhou, L Li, X Qiu, J Wu, L Xu, W Shao
    Mol Med Rep, 2020-06-02;22(2):1489-1497.
    Species: Rat
    Sample Types: Cell Culture Supernates
  74. Amelioration of age-related alterations in rat liver: Effects of curcumin C3 complex, Astragalus membranaceus and blueberry
    Authors: AM Selim, MM Nooh, MM El-Sawalhi, NA Ismail
    Exp. Gerontol., 2020-05-22;137(0):110982.
    Species: Rat
    Sample Types: Serum
  75. Impaired integrin &alpha5 /&beta1 -mediated hepatocyte growth factor release by stellate cells of the aged liver
    Authors: F Rohn, C Kordes, T Buschmann, D Reichert, M Wammers, G Poschmann, K Stühler, AS Benk, F Geiger, JP Spatz, D Häussinger
    Aging Cell, 2020-03-11;0(0):e13131.
    Species: Rat
    Sample Types: Cell Culture Supernates
  76. Remote Ischemic Preconditioning induces Cardioprotective Autophagy and Signals through the IL-6-Dependent JAK-STAT Pathway
    Authors: M Billah, A Ridiandrie, UK Allahwala, H Mudaliar, A Dona, S Hunyor, LM Khachigian, R Bhindi
    Int J Mol Sci, 2020-03-01;21(5):.
    Species: Rat
    Sample Types: Plasma
  77. Effect of Immune Activation during Early Gestation or Late Gestation on Inhibitory Markers in Adult Male Rats
    Authors: T Rahman, CS Weickert, L Harms, C Meehan, U Schall, J Todd, DM Hodgson, PT Michie, T Purves-Tys
    Sci Rep, 2020-02-06;10(1):1982.
    Species: Rat
    Sample Types: Plasma
  78. Comparison of the acute toxicity, analgesic and anti-inflammatory activities and chemical composition changes in Rhizoma anemones Raddeanae caused by vinegar processing
    Authors: SS Wang, SY Zhou, XY Xie, L Zhao, Y Fu, GZ Cai, JY Gong
    BMC Complement Med Ther, 2020-01-15;20(1):7.
    Species: Rat
    Sample Types: Serum
  79. Identification of microRNA?363?3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53?signaling pathway
    Authors: M Zhang, Z Wang, B Li, F Sun, A Chen, M Gong
    Mol Med Rep, 2020-01-14;21(3):1077-1088.
    Species: Rat
    Sample Types: Synovial Fluid
  80. Moderate-intensity physical activity reduces systemic inflammation and maintains cardiorespiratory function following chronic particulate matter2.5 exposure in rats
    Authors: A van Wavere, MJ Duncan, F Coulson, A Fenning
    Toxicol Rep, 2019-12-17;7(0):93-100.
    Species: Rat
    Sample Types: Serum
  81. Hemorrhagic Shock Sensitized the Diaphragm to Ventilator-Induced Dysfunction through the Activation of IL-6/JAK/STAT Signaling-Mediated Autophagy in Rats
    Authors: LJ Zhang, SZ Ni, XL Zhou, Y Zhao
    Mediators Inflamm., 2019-11-14;2019(0):3738409.
    Species: Rat
    Sample Types: Tissue Homogenates
  82. Neutrophil activation causes tumor regression in Walker 256 tumor-bearing rats
    Authors: WMT Kuwabara, J Andrade-Si, JNB Pereira, JH Scialfa, J Cipolla-Ne
    Sci Rep, 2019-11-11;9(1):16524.
    Species: Rat
    Sample Types: BALF
  83. CoQ10 ameliorates monosodium glutamate-induced alteration in detrusor activity and responsiveness in rats via anti-inflammatory, anti-oxidant and channel inhibiting mechanisms
    Authors: DF El Agamy, YM Naguib
    BMC Urol, 2019-10-28;19(1):103.
    Species: Rat
    Sample Types: Serum
  84. Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model
    Authors: CC Hsiao, CC Lin, YS Hou, JY Ko, CJ Wang
    Int J Mol Sci, 2019-10-05;20(19):.
    Species: Rat
    Sample Types: Tissue Lysates
  85. Low-Energy Extracorporeal Shock Wave Therapy Ameliorates Kidney Function in Diabetic Nephropathy
    Authors: CC Hsiao, WH Huang, KH Cheng, CT Lee
    Oxid Med Cell Longev, 2019-07-04;2019(0):8259645.
    Species: Rat
    Sample Types: Tissue Lysates
  86. Rice Porridge Containing Welsh Onion Root Water Extract Alleviates Osteoarthritis-Related Pain Behaviors, Glucose Levels, and Bone Metabolism in Osteoarthritis-Induced Ovariectomized Rats
    Authors: HJ Yang, MJ Kim, JY Qiu, T Zhang, X Wu, DJ Jang, S Park
    Nutrients, 2019-06-30;11(7):.
    Species: Rat
    Sample Types: Serum
  87. Sex-specific maternofetal innate immune responses triggered by group B Streptococci
    Authors: MJ Allard, A Giraud, M Segura, G Sebire
    Sci Rep, 2019-06-13;9(1):8587.
    Species: Rat
    Sample Types: Protein
  88. Extract from Coriolus versicolor fungus partially prevents endotoxin tolerance development by maintaining febrile response and increasing IL-6 generation
    Authors: T J?drzejews, J Piotrowski, M Pawlikowsk, S Wrotek, W Kozak
    J. Therm. Biol., 2019-05-16;83(0):69-79.
    Species: Rat
    Sample Types: Cell Culture Supernates
  89. Ascorbic acid deficiency increases hepatic expression of acute phase proteins through the intestine-derived IL-6 and hepatic STAT3 pathway in ODS rats
    Authors: N Kawade, A Murai, W Suzuki, Y Tokuda, M Kobayashi, F Horio
    J. Nutr. Biochem., 2019-05-14;70(0):116-124.
    Species: Rat
    Sample Types: Serum
  90. Atractylenolide III Attenuates Muscle Wasting in Chronic Kidney Disease via the Oxidative Stress-Mediated PI3K/AKT/mTOR Pathway
    Authors: M Wang, R Hu, Y Wang, L Liu, H You, J Zhang, X Wu, T Pei, F Wang, L Lu, W Xiao, L Wei
    Oxid Med Cell Longev, 2019-04-18;2019(0):1875471.
    Species: Rat
    Sample Types: Serum
  91. Exosomes derived from mangiferin?stimulated perivascular adipose tissue ameliorate endothelial dysfunction
    Authors: Q Zhao, J Yang, B Liu, F Huang, Y Li
    Mol Med Rep, 2019-04-04;0(0):.
    Species: Rat
    Sample Types: Cell Culture Supernates
  92. Trans-repression of NF?B pathway mediated by PPAR? improves vascular endothelium insulin resistance
    Authors: Y Kong, Y Gao, D Lan, Y Zhang, R Zhan, M Liu, Z Zhu, G Zeng, Q Huang
    J. Cell. Mol. Med., 2018-11-05;0(0):.
    Species: Rat
    Sample Types: Serum
  93. Local Delivery of ?-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury
    Authors: J Wang, H Li, Y Ren, Y Yao, J Hu, M Zheng, Y Ding, YY Chen, Y Shen, LL Wang, Y Zhu
    Cell. Physiol. Biochem., 2018-08-30;49(2):595-609.
    Species: Rat
    Sample Types: Tissue Homogenates
  94. Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine
    Authors: MRH Dutra, RDS Feliciano, KR Jacinto, TLF Gouveia, E Brigidio, AJ Serra, M Morris, MDG Naffah-Maz, JA Silva
    Oxid Med Cell Longev, 2018-08-06;2018(0):6736721.
    Species: Rat
    Sample Types: Tissue Homogenates
  95. Cobra Venom Factor-induced complement depletion protects against lung ischemia reperfusion injury through alleviating blood-air barrier damage
    Authors: C Haihua, W Wei, H Kun, L Yuanli, L Fei
    Sci Rep, 2018-07-09;8(1):10346.
    Species: Rat
    Sample Types: BALF
  96. Dexamethasone-induced Intra-Uterine Growth Restriction impacts NOSTRIN and its downstream effector genes in the rat mesometrial uterus
    Authors: S Chakrabort, S Islam, S Saha, R Ain
    Sci Rep, 2018-05-29;8(1):8342.
    Species: Human
    Sample Types: Tissue Homogenates
  97. Autophagy mediates tumor necrosis factor-?-induced phenotype switching in vascular smooth muscle A7r5 cell line
    Authors: M García-Mig, JA Riquelme, I Norambuena, PE Morales, F Sanhueza-O, C Nuñez-Soto, D Mondaca-Ru, N Cancino-Ar, A San Martín, M Chiong
    PLoS ONE, 2018-05-11;13(5):e0197210.
    Species: Rat
    Sample Types: Cell Culture Supernates
  98. Radiofrequency ablation (RFA) induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins
    Authors: M Ahmed, G Kumar, S Gourevitch, T Levchenko, E Galun, V Torchilin, SN Goldberg
    Int J Hyperthermia, 2018-04-24;0(0):1-25.
    Species: Rat
    Sample Types: Serum
  99. Timing matters: the interval between acute stressors within chronic mild stress modifies behavioral and physiologic stress responses in male rats
    Authors: SA Cavigelli, AD Bao, RA Bourne, MJ Caruso, JI Caulfield, M Chen, JM Smyth
    Stress, 2018-04-12;0(0):1-11.
    Species: Rat
    Sample Types: Serum
  100. Anti-inflammatory effect of Mongolian drug Naru-3 on traumatic spinal cord injury and its mechanism of action
    Authors: B Baiyila, B He, G He, T Long
    J. Int. Med. Res., 2018-04-03;0(0):3000605187601.
    Species: Rat
    Sample Types: Serum
  101. The local cytokine and growth factor response to rhBMP-2 after spinal fusion
    Authors: JD Koerner, DZ Markova, GD Schroeder, BP Calio, A Shah, CW Brooks, AR Vaccaro, DG Anderson, CK Kepler
    Spine J, 2018-03-14;0(0):.
    Species: Rat
    Sample Types: Tissue Lysates
    Applications: ELISA (Standard)
  102. Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders
    Authors: S Hagan, MCT Fyfe, B Ofori-Frim, K Oliver, MR Foster, S Sirohi, Y Solanke, M Doughty, A Rowley, M Taylor, S Webber, CA Walshe
    Invest. Ophthalmol. Vis. Sci., 2018-03-01;59(3):1443-1453.
    Species: Rat
    Sample Types: Tissue Homogenates
  103. Ablation of the Right Cardiac Vagus Nerve Reduces Acetylcholine Content without Changing the Inflammatory Response during Endotoxemia
    Authors: K Plaschke, TQM Do, F Uhle, T Brenner, MA Weigand, J Kopitz
    Int J Mol Sci, 2018-02-01;19(2):.
    Species: Rat
    Sample Types: Plasma
  104. The Potential Therapeutic Role of Peroxisome ProliferatorActivated Receptors Agonist in Preeclamptic Pregnant Rats
    Authors: HIG Allam, AAA Masri
    J Coll Physicians Surg Pak, 2018-01-01;28(1):31-35.
    Species: Rat
    Sample Types: Plasma
  105. Intraneural injection of ATP stimulates regeneration of primary sensory axons in the spinal cord
    Authors: D Wu, S Lee, J Luo, H Xia, S Gushchina, PM Richardson, J Yeh, U Krügel, H Franke, Y Zhang, X Bo
    J. Neurosci., 2017-12-26;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  106. Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus)
    Authors: BG Lania, J Morari, AL Souza, MND Silva, AR de Almeida, G Veira-Dami, SM Alegre, CL César, LA Velloso, ML Cintra, NB Maia, PENF Velho
    PLoS ONE, 2017-12-13;12(12):e0188779.
    Species: Rat
    Sample Types: Serum
  107. Protective effects of GV1001 on myocardial ischemia?reperfusion injury
    Authors: JE Chang, HJ Kim, S Jheon, C Lim
    Mol Med Rep, 2017-09-19;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  108. Short-term treatment with taurolidine is associated with liver injury
    Authors: R Fahrner, A Möller, AT Press, A Kortgen, M Kiehntopf, F Rauchfuss, U Settmacher, AS Mosig
    BMC Pharmacol Toxicol, 2017-08-11;18(1):61.
    Species: Rat
    Sample Types: Serum
  109. Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system
    Authors: K Yan, Y Shen
    Mol Med Rep, 2017-07-28;0(0):.
    Species: Rat
    Sample Types: Serum
  110. Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate?induced osteoarthritis rats
    Authors: JW Jeong, HH Lee, J Kim, EO Choi, H Hwang-Bo, HJ Kim, MY Kim, KI Ahn, GY Kim, KW Lee, KY Kim, SG Kim, SH Hong, C Park, HJ Cha, YH Choi
    Mol Med Rep, 2017-07-21;0(0):.
    Species: Rat
    Sample Types: Serum
  111. Maternal-placental-fetal biodistribution of multimodal polymeric nanoparticles in a pregnant rat model in mid and late gestation
    Authors: D Ho, JW Leong, RC Crew, M Norret, MJ House, PJ Mark, BJ Waddell, KS Iyer, JA Keelan
    Sci Rep, 2017-06-06;7(1):2866.
    Species: Rat
    Sample Types: Plasma
  112. The P2X7 receptor links mechanical strain to cytokine IL-6 upregulation and release in neurons and astrocytes
    Authors: W Lu, F Albalawi, JM Beckel, JC Lim, AM Laties, CH Mitchell
    J. Neurochem, 2017-05-01;0(0):.
    Species: Rat
    Sample Types: Cell Lysates
  113. Anti-aging effect and gene expression profiling of dung beetle glycosaminoglycan in aged rats
    Authors: MY Ahn, BJ Kim, HJ Kim, JS Hwang, YS Jung, KK Park
    Biomater Res, 2017-04-21;21(0):5.
    Species: Rat
    Sample Types: Serum
  114. The Effects of Remifentanil on Expression of High Mobility Group Box 1 in Septic Rats
    Authors: KH Seo, JW Choi, HS Jung, H Yoo, JD Joo
    J. Korean Med. Sci, 2017-03-01;32(3):542-551.
    Species: Rat
    Sample Types: Serum
  115. Negligible Oval Cell Proliferation Following Ischemia-Reperfusion Injury With and Without Partial Hepatectomy
    Authors: EK Tan, M Shuh, H Francois-V, JA Sanders, AJ Cohen
    Ochsner J, 2017-01-01;17(1):31-37.
    Species: Rat
    Sample Types: Serum
  116. Investigation of the effect of phlomisoside F on complete Freund's adjuvant-induced arthritis
    Authors: X Zhang, Y Dong, H Dong, W Zhang, F Li
    Exp Ther Med, 2016-12-22;13(2):710-716.
    Species: Rat
    Sample Types: Serum
  117. Postconditioning: Toll-erating mesenteric ischemia-reperfusion injury?
    Authors: Attila Szijártó
    Surgery, 2016-11-11;0(0):.
    Species: Rat
    Sample Types: Serum
  118. The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain
    Authors: Chi-Hua Guo
    Int. J. Mol. Med, 2016-09-30;38(5):1433-1442.
    Species: Rat
    Sample Types: Tissue Homogenates
  119. IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation.
    Authors: Sun J, Zhang S, Zhang X, Zhang X, Dong H, Qian Y
    J Neuroinflammation, 2015-09-15;12(0):165.
    Species: Rat
    Sample Types: Cell Culture Supernates
  120. Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat.
    Authors: Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin D, Nakamura K, Honda M, Inoue K, Saito M
    PLoS ONE, 2015-08-26;10(8):e0133798.
    Species: Rat
    Sample Types: Tissue Homogenates
  121. Systemic siRNA Nanoparticle-Based Drugs Combined with Radiofrequency Ablation for Cancer Therapy.
    Authors: Ahmed M, Kumar G, Navarro G, Wang Y, Gourevitch S, Moussa M, Rozenblum N, Levchenko T, Galun E, Torchilin V, Goldberg S
    PLoS ONE, 2015-07-08;10(7):e0128910.
    Species: Rat
    Sample Types: Serum
  122. Iron-hepcidin dysmetabolism, anemia and renal hypoxia, inflammation and fibrosis in the remnant kidney rat model.
    Authors: Garrido P, Ribeiro S, Fernandes J, Vala H, Bronze-da-Rocha E, Rocha-Pereira P, Belo L, Costa E, Santos-Silva A, Reis F
    PLoS ONE, 2015-04-13;10(4):e0124048.
    Species: Rat
    Sample Types: Serum
  123. The extent of irradiation-induced long-term visceral organ damage depends on cranial/brain exposure.
    Authors: Boittin F, Denis J, Mayol J, Martigne P, Raffin F, Coulon D, Grenier N, Drouet M, Herodin F
    PLoS ONE, 2015-04-02;10(4):e0122900.
    Species: Rat
    Sample Types: Plasma
  124. Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain.
    Authors: Tang J, Zhu C, Li Z, Liu X, Sun S, Zhang T, Luo Z, Zhang H, Li W
    J Neuroinflammation, 2015-03-25;12(0):57.
    Species: Rat
    Sample Types: Tissue Homogenates
  125. Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways.
    Authors: Gu, Wen, Song, Lin, Li, Xiao-Min, Wang, Di, Guo, Xue-Jun, Xu, Wei-Guo
    Sci Rep, 2015-03-04;5(0):8733.
    Species: Rat
    Sample Types: BALF
  126. Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer.
    Authors: Chuffa L, Fioruci-Fontanelli B, Mendes L, Ferreira Seiva F, Martinez M, Favaro W, Domeniconi R, Pinheiro P, Delazari Dos Santos L, Martinez F
    BMC Cancer, 2015-02-06;15(0):34.
    Species: Rat
    Sample Types: Tissue Culture Supernates
  127. Catalpol ameliorates sodium taurocholate-induced acute pancreatitis in rats via inhibiting activation of nuclear factor kappa B.
    Authors: Xiao W, Yin G, Fan Y, Qiu L, Cang X, Yu G, Hu Y, Xing M, Wu D, Wang X, Hu G, Wan R
    Int J Mol Sci, 2014-07-04;15(7):11957-72.
    Species: Rat
    Sample Types: Serum
  128. Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat.
    Authors: Wang Z, Huang W, Zuo Z
    J Neuroinflammation, 2014-03-25;11(0):56.
    Species: Rat
    Sample Types: Whole Tissue
  129. Transplanted neural stem cells modulate regulatory T, gammadelta T cells and corresponding cytokines after intracerebral hemorrhage in rats.
    Authors: Gao L, Lu Q, Huang L, Ruan L, Yang J, Huang W, ZhuGe W, Zhang Y, Fu B, Jin K, ZhuGe Q
    Int J Mol Sci, 2014-03-13;15(3):4431-41.
    Species: Rat
    Sample Types: Serum
  130. Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission.
    Authors: Shinozaki Y, Nomura M, Iwatsuki K, Moriyama Y, Gachet C, Koizumi S
    Sci Rep, 2014-03-10;4(0):4329.
    Species: Rat
    Sample Types: Cell Culture Supernates
  131. Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca(2+) signals and an IL-6 autocrine loop.
    Authors: Bustamante M, Fernandez-Verdejo R, Jaimovich E, Buvinic S
    Am J Physiol Endocrinol Metab, 2014-02-11;306(8):E869-82.
    Species: Rat
    Sample Types: Cell Culture Supernates
  132. Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.
    Authors: Wilson C, Mann J, Walsh M, Perrugoria M, Oakley F, Wright M, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann D
    PLoS ONE, 2014-01-08;9(1):e83391.
    Species: Mouse, Rat
    Sample Types: Cell Culture Supernates
  133. Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model.
    Authors: Ding N, Wang F, Xiao H, Xu L, She S
    PLoS ONE, 2013-09-10;8(9):e74633.
    Species: Rat
    Sample Types: BALF
  134. Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker.
    Authors: Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira F, Reis F
    Cardiovasc Diabetol, 2013-03-07;12(0):44.
    Species: Rat
    Sample Types: Serum
  135. Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.
    Authors: Leone E, Morelli E, Di Martino M, Amodio N, Foresta U, Gulla A, Rossi M, Neri A, Giordano A, Munshi N, Anderson K, Tagliaferri P, Tassone P
    Clin Cancer Res, 2013-02-27;19(8):2096-106.
    Species: Human
    Sample Types: Cell Culture Supernates
  136. A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion.
    Cytokine, 2012-12-23;61(2):614-21.
    Species: Rat
    Sample Types: BALF
  137. Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture.
    Authors: Francque S, Laleman W, Verbeke L, Van Steenkiste C, Casteleyn C, Kwanten W, Van Dyck C
    Lab Invest, 2012-08-13;92(10):1428-39.
    Species: Rat
    Sample Types: Serum
  138. Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain.
    J Neuroinflammation, 2012-07-23;9(0):181.
    Species: Rat
    Sample Types: Tissue Homogenates
  139. Vipera aspis venom reduces lethality and down-regulates tumor necrosis factor-alpha in a rat model of LPS-induced sepsis.
    Authors: Frolkis I, Klein Y, Locker C, Adi N, Dahan E, Uretzsky G, Shapira I, Sorkine P
    Cytokine, 2010-01-19;49(3):319-24.
    Species: Rat
    Sample Types: Serum
  140. Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis.
    Authors: Costello J, Higgins B, Contreras M, Chonghaile MN, Hassett P, O'Toole D, Laffey JG
    Crit. Care Med., 2009-08-01;37(8):2412-20.
    Species: Rat
    Sample Types: BALF
  141. In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland.
    Authors: Sanchez-Lemus E, Benicky J, Pavel J, Saavedra JM
    Brain Behav. Immun., 2009-05-07;23(7):945-57.
    Species: Rat
    Sample Types: Plasma
  142. Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses.
    Authors: Yang S, Hu S, Chen J, Choudhry MA, Rue LW, Bland KI, Chaudry IH
    J. Leukoc. Biol., 2009-02-24;85(6):1015-26.
    Species: Rat
    Sample Types: Serum
  143. JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat.
    Authors: Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M
    J. Neurochem., 2008-07-12;107(1):50-60.
    Species: Rat
    Sample Types: Tissue Homogenates
  144. Role of central beta-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge.
    Authors: Johnson JD, Cortez V, Kennedy SL, Foley TE, Hanson H, Fleshner M
    Brain Behav. Immun., 2008-05-12;22(7):1078-86.
    Species: Rat
    Sample Types: Plasma
  145. Regulation of liver cytochrome P450 by activation of brain dopaminergic system: physiological and pharmacological implications.
    Authors: Wojcikowski J, Golembiowska K, Daniel WA
    Biochem. Pharmacol., 2008-05-03;76(2):258-67.
    Species: Rat
    Sample Types: Plasma
  146. Induction of type 2 iodothyronine deiodinase in the mediobasal hypothalamus by bacterial lipopolysaccharide: role of corticosterone.
    Authors: Sanchez E, Singru PS, Fekete C, Lechan RM
    Endocrinology, 2008-01-24;149(5):2484-93.
    Species: Rat
    Sample Types: Serum
  147. Trauma and hemorrhage-induced acute hepatic insulin resistance: dominant role of tumor necrosis factor-alpha.
    Authors: Xu J, Kim HT, Ma Y, Zhao L, Zhai L, Kokorina N, Wang P, Messina JL
    Endocrinology, 2008-01-10;149(5):2369-82.
    Species: Rat
    Sample Types: Serum
  148. Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats.
    Authors: Choi G, Hofstra JJ, Roelofs JJ, Rijneveld AW, Bresser P, van der Zee JS, Florquin S, van der Poll T, Levi M, Schultz MJ
    Crit. Care Med., 2008-01-01;36(1):204-10.
    Species: Rat
    Sample Types: BALF
  149. ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin.
    Authors: Wosten-van Asperen RM, Lutter R, Haitsma JJ, Merkus MP, van Woensel JB, van der Loos CM, Florquin S, Lachmann B, Bos AP
    Eur. Respir. J., 2007-10-24;31(2):363-71.
    Species: Rat
    Sample Types: BALF
  150. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.
    Authors: Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Butler K
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007-08-24;293(5):L1183-93.
    Species: Rat
    Sample Types: BALF
  151. Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway.
    Authors: Yu HP, Hsieh YC, Suzuki T, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
    J. Leukoc. Biol., 2007-06-22;82(3):774-80.
    Species: Rat
    Sample Types: Tissue Homogenates
  152. Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation.
    Authors: Choi G, Vlaar AP, Schouten M, Van't Veer C, van der Poll T, Levi M, Schultz MJ
    Eur. Respir. J., 2007-05-30;30(3):423-8.
    Species: Rat
    Sample Types: Tissue Homogenates
  153. Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat.
    Authors: Sheikh N, Dudas J, Ramadori G
    Lab. Invest., 2007-04-09;87(7):713-25.
    Species: Rat
    Sample Types: Serum
  154. Cell-based angiopoietin-1 gene therapy for acute lung injury.
    Authors: McCarter SD, Mei SH, Lai PF, Zhang QW, Parker CH, Suen RS, Hood RD, Zhao YD, Deng Y, Han RN, Dumont DJ, Stewart DJ
    Am. J. Respir. Crit. Care Med., 2007-02-22;175(10):1014-26.
    Species: Rat
    Sample Types: BALF
  155. Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage.
    Authors: Yang S, Hu S, Choudhry MA, Rue LW, Bland KI, Chaudry IH
    J. Mol. Cell. Cardiol., 2006-12-16;42(3):620-30.
    Species: Rat
    Sample Types: Plasma
  156. Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure.
    Authors: Holly MK, Dear JW, Hu X, Schechter AN, Gladwin MT, Hewitt SM, Yuen PS, Star RA
    Kidney Int., 2006-06-07;70(3):496-506.
    Species: Rat
    Sample Types: Serum
  157. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
    Authors: Barkho BZ, Song H, Aimone JB
    Stem Cells Dev., 2006-06-01;15(3):407-21.
    Species: Rat
    Sample Types: Cell Culture Supernates
  158. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin.
    Authors: Satofuka S, Ichihara A, Nagai N, Yamashiro K, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Suzuki F, Oike Y, Ishida S
    Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2686-92.
    Species: Rat
    Sample Types: Tissue Homogenates
  159. Glucosamine administration during resuscitation improves organ function after trauma hemorrhage.
    Authors: Yang S, Zou LY, Bounelis P, Chaudry I, Chatham JC, Marchase RB
    Shock, 2006-06-01;25(6):600-7.
    Species: Rat
    Sample Types: Plasma
  160. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth.
    Authors: Cao Z, Gao Y, Bryson JB, Hou J, Chaudhry N, Siddiq M, Martinez J, Spencer T, Carmel J, Hart RB, Filbin MT
    J. Neurosci., 2006-05-17;26(20):5565-73.
    Species: Rat
    Sample Types: Cell Culture Supernates
  161. Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.
    Authors: Chen CC, Wang SS, Tsay SH, Lee FY, Lu RH, Chang FY, Lee SD
    Cytokine, 2006-02-10;33(2):95-9.
    Species: Rat
    Sample Types: Serum
  162. Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat.
    Authors: Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B
    Crit. Care Med., 2005-10-01;33(10):2317-22.
    Species: Rat
    Sample Types: BALF, Plasma
  163. Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats.
    Authors: Robinson S, Petelenz K, Li Q, Cohen ML, Dechant A, Tabrizi N, Bucek M, Lust D, Miller RH
    Neurobiol. Dis., 2005-04-01;18(3):568-81.
    Species: Rat
    Sample Types: Amniotic Fluid
  164. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
    Authors: Holguin A, O&amp;apos;Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR
    Pain, 2004-08-01;110(3):517-30.
    Species: Rat
    Sample Types: CSF
  165. Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor.
    Authors: Nishida T, Miyata S, Itoh Y, Mizuki N, Ohgami K, Shiratori K, Ilieva IB, Ohno S, Taylor AW
    Int. Immunopharmacol., 2004-08-01;4(8):1059-66.
    Species: Rat
    Sample Types: Aqueous Humor
  166. Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma.
    Authors: Schubert T, Horch RE
    Ann. Surg., 2004-08-01;240(2):340-9.
    Species: Rat
    Sample Types: Tissue Homogenates
  167. Insulin attenuates the systemic inflammatory response in endotoxemic rats.
    Authors: Jeschke MG, Klein D, Bolder U, Einspanier R
    Endocrinology, 2004-06-10;145(9):4084-93.
    Species: Rat
    Sample Types: Tissue Homogenates
  168. A method for measuring multiple cytokines from small samples.
    Authors: O&amp;apos;Connor KA
    Brain Behav. Immun., 2004-05-01;18(3):274-80.
    Species: Rat
    Sample Types: CSF
  169. Differential expression of cytokine genes and inducible nitric oxide synthase induced by opacity phenotype variants of Streptococcus pneumoniae during acute otitis media in the rat.
    Authors: Long JP, Tong HH, Shannon PA, DeMaria TF
    Infect. Immun., 2003-10-01;71(10):5531-40.
    Species: Rat
    Sample Types: Tissue Secretion
  170. Iron intake increases infarct volume after permanent middle cerebral artery occlusion in rats.
    Authors: Castellanos M, Puig N, Carbonell T, Castillo J, Martinez J, Rama R, Davalos A
    Brain Res., 2002-10-11;952(1):1-6.
    Species: Rat
    Sample Types: Serum

FAQs

  1. Does this kit detect Cotton Rat IL-6?

    • Cotton Rat has not been evaluated in this kit. R&D Systems recommends the Cotton Rat IL-6 DuoSet ELISA (catalog # DY561) for measuring IL-6 in Cotton Rat species.

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