Rat mGluR2/3 Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of mGluR2/3 by Western Blot Western blot of rat hippocampal lysate showing the specific immunolabeling of the ~110 kDa monomer and the ~220 kDa dimer of mGluR2 and mGluR3.
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Preparation and Storage
Background: mGluR2/3
Rat metabotropic glutamate receptor 2 (mGluR2; also mGlu2) is a 95 kDa, 854 amino acid (aa), 7-transmembrane glycoprotein that belongs to group II of the C-family of G-protein coupled receptors. Group II receptors include mGluR2 and mGluR3. Both are presynaptic, considered to negatively regulate the release of glutamate, associate with Gi/Go proteins, and inhibit adenylate cyclase, thus decreasing cAMP concentration. The effects of mGluR2 and 3 are not always identical. On microglia, mGluR2 but not mGluR3 stimulation induces TNF-alpha release. mGluR2 is believed to exist as a dimer. Dimerization presumably creates two subunit-linked “open clamshells” which first bind glutamate, then close, and subsequently undergo rearrangement for signal transduction. The cytoplasmic tails of rat mGluR2 and mGluR3 are 64% aa identical; over the last 18 aa, they are 95% aa identical.
- Rudd, M.T. and J.A. Mccauley (2005) Curr. Top. Med. Chem. 5:869.
- Gasparini, F. et al. (2002) Curr. Opin. Pharmacol. 2:43.
- Ferraguti, F. and R. Shigemoto (2006) Cell Tissue Res. 326:483.
- Shen, K-Z. and S.W. Johnson (2003) J. Physiol. 533:489.
- Taylor, D.L. et al. (2005) J. Neurosci. 25:2952.
Product Datasheets
Citation for Rat mGluR2/3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress.
Authors: Shin S, Kwon O, Kang J, Kwon S, Oh S, Choi J, Kim C, Kim D
Nat Neurosci, 2015-05-25;18(7):1017-24.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot
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