Home / IL-22 / Recombinant Human IL-22 Protein

Recombinant Human IL-22 Protein

Catalog #: 782-IL
65 Citations Datasheet / COA / SDS
E. coli

Carrier Free

Catalog # Availability Size / Price Qty
782-IL-010/CF

With Carrier

Catalog # Availability Size / Price Qty
782-IL-010
Best Seller
Recombinant Human IL-22 Protein Bioactivity
2 Images
Product Details
Citations (65)
FAQs
Reviews
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IL-22 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Nagalakshmi, M.L. et al. (2004) International Immunopharmacology 4:679. The ED50 for this effect is 60-300 pg/mL.
Source
E. coli-derived human IL-22 protein
Ala34-Ile179, with an N-terminal Met
Accession #
Q9GZX6
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
16.5 kDa

Product Datasheets

You must select a language.

x

782-IL (with carrier)

Product Datasheet
COA
SDS

You must select a language.

x

782-IL/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

782-IL

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

782-IL/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human IL-22 Protein Bioactivity View Larger

Recombinant Human IL-22 (Catalog # 782-IL) induces IL-10 secretion in the COLO 205 human colorectal adenocarcinoma cell line. The ED50 for this effect is 60-300 pg/mL.

SDS-PAGE Recombinant Human IL-22 Protein SDS-PAGE View Larger

1 µg/lane of Recombinant Human IL‑22 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background: IL-22

Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Human IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with mouse IL-22 and human IL-10, respectively. The human IL-22 gene is localized to chromosome 12q15. Although it exists as a single copy gene in human and in many mouse strains, the mouse IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta, share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate STAT‑1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.

References
  1. Dumoutier, L. et al. (2000) J. Immunol. 164:1814.
  2. Xie, M-H. et al. (2000) J. Biol. Chem. 275:31335.
  3. Dumoutier, L. et al. (2000) PNAS 97:10144.
  4. Kotenko, S.V. et al. (2001) J. Biol. Chem. 276:2725.
Long Name
Interleukin 22
Entrez Gene IDs
50616 (Human); 50929 (Mouse); 500836 (Rat)
Alternate Names
Cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL22; IL-22; IL-D110; IL-TIF; ILTIFIL-10-related T-cell-derived-inducible factor; IL-TIFMGC79382; interleukin 22; interleukin-22; MGC79384; TIFa; TIFIL-23; zcyto18

Citations for Recombinant Human IL-22 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

65 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells
    Authors: C Maresca, G Di Maggio, C Stolfi, F Laudisi, M Colella, T Pacifico, A Di Grazia, D Di Fusco, D Congiu, AM Guida, G Sica, I Monteleone, G Monteleone
    Cancers, 2022-10-12;14(20):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  2. Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract
    Authors: S Segarra, T Naiken, J Garnier, V Hamon, N Coussay, FX Bernard
    Oncogene, 2022-06-27;9(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cells
    Authors: DJ Carroll, MWN Burns, L Mottram, DC Propheter, A Boucher, GM Lessen, A Kumar, SA Malaker, C Xing, LV Hooper, U Yrlid, JJ Kohler
    The Journal of Biological Chemistry, 2021-12-02;0(0):101463.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  4. PI3Kdelta Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis
    Authors: L Mercurio, M Morelli, C Scarponi, GL Scaglione, S Pallotta, C Albanesi, S Madonna
    Cells, 2021-10-02;10(10):.
    Species: Human
    Sample Types: Whole Cell
    Applications: Stimulation
  5. miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response
    Authors: F Abdallah, E Henriet, A Suet, A Arar, R Clemençon, JM Malinge, G Lecellier, P Baril, C Pichon
    Cells, 2021-09-26;10(10):.
    Species: Human
    Sample Types: Whole Cell
    Applications: Stimulation
  6. Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation
    Authors: HC Hawerkamp, A Domdey, L Radau, P Sewerin, P Oláh, B Homey, S Meller
    Arthritis Research & Therapy, 2021-05-21;23(1):144.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&kappaB&alpha pathway
    Authors: HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim
    Arthritis Research & Therapy, 2020-09-23;22(1):222.
    Species: Human
    Sample Types: Reference Standard
  8. Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet
    Authors: EY Kim, HM Noh, B Choi, JE Park, JE Kim, Y Jang, HK Lee, EJ Chang
    Cells, 2019-12-06;8(12):.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues
    Authors: X Xu, H Fukui, Y Ran, X Wang, Y Inoue, N Ebisudani, H Nishimura, T Tomita, T Oshima, J Watari, H Kiyama, H Miwa
    Mediators Inflamm., 2019-11-06;2019(0):7859460.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection
    Authors: KD Hebert, N Mclaughlin, M Galeas-Pen, Z Zhang, T Eddens, A Govero, JM Pilewski, JK Kolls, DA Pociask
    Mucosal Immunol, 2019-10-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models
    Authors: JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar
    Cells, 2019-09-15;8(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes
    Authors: S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane
    J. Dermatol. Sci., 2019-08-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  13. IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis
    Authors: H Lindahl, AO Guerreiro-, SK Bedri, M Linnerbaue, M Lindén, N Abdelmagid, K Tandre, C Hollins, L Irving, C Glover, C Jones, L Alfredsson, L Rönnblom, I Kockum, M Khademi, M Jagodic, T Olsson
    J. Immunol., 2019-07-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
    Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
    Cell Death Dis, 2019-03-20;10(4):274.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. R. nukuhivensis acts by reinforcing skin barrier function, boosting skin immunity and by inhibiting IL-22 induced keratinocyte hyperproliferation
    Authors: F Abdallah, G Lecellier, P Raharivelo, C Pichon
    Sci Rep, 2019-03-11;9(1):4132.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. IL-36? regulates mediators of tissue homeostasis in epithelial cells
    Authors: JE Heath, GM Scholz, PD Veith, EC Reynolds
    Cytokine, 2019-03-08;119(0):24-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment
    Authors: L Mercurio, M Morelli, C Scarponi, EZ Eisenmesse, N Doti, G Pagnanelli, E Gubinelli, C Mazzanti, A Cavani, M Ruvo, CA Dinarello, C Albanesi, S Madonna
    Cell Death Dis, 2018-10-30;9(11):1104.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Ruxolitinib inhibits cyclosporine-induced proliferation of cutaneous squamous cell carcinoma
    Authors: M Abikhair B, N Roudiani, J Chen, AL Santana, N Doudican, C Proby, D Felsen, JA Carucci
    JCI Insight, 2018-09-06;3(17):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses
    Authors: BA Stanfield, PJF Rider, J Caskey, F Del Piero, KG Kousoulas
    Vaccine, 2018-04-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum
    Authors: L Bin, X Li, B Richers, JE Streib, JW Hu, P Taylor, DYM Leung
    J. Allergy Clin. Immunol., 2018-01-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT
    Authors: S Abadpour, B Halvorsen, A Sahraoui, O Korsgren, P Aukrust, H Scholz
    J. Mol. Endocrinol., 2018-01-12;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  22. Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts
    Authors: S Sawamura, M Jinnin, K Inoue, K Yamane, N Honda, I Kajihara, T Makino, S Masuguchi, S Fukushima, H Ihn
    J. Dermatol. Sci., 2017-12-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model
    Authors: R Bichele, J Kärner, K Truusalu, I Smidt, R Mändar, HR Conti, SL Gaffen, P Peterson, M Laan, K Kisand
    Eur. J. Immunol., 2017-12-11;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Bcl-3 induced by IL-22 via STAT3 activation acts as a potentiator of psoriasis-related gene expression in epidermal keratinocytes
    Authors: M Tohyama, Y Shirakata, Y Hanakawa, X Dai, K Shiraishi, M Murakami, S Miyawaki, H Mori, R Utsunomiya, K Masuda, K Hashimoto, K Sayama
    Eur. J. Immunol., 2017-11-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
    Authors: Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang
    J. Immunol., 2017-09-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
    Authors: E Couderc, F Morel, P Levillain, A Buffière-M, M Camus, C Paquier, C Bodet, JF Jégou, M Pohin, L Favot, M Garcia, V Huguier, J Mcheik, C Lacombe, H Yssel, G Guillet, FX Bernard, JC Lecron
    PLoS ONE, 2017-07-14;12(7):e0181486.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. The pathogenic role of interleukin-22 and its receptor during UVB-induced skin inflammation
    Authors: Y Kim, J Lee, J Kim, CW Choi, YI Hwang, JS Kang, WJ Lee
    PLoS ONE, 2017-05-30;12(5):e0178567.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces
    Authors: S La Manna, PL Scognamigl, C Di Natale, M Leone, FA Mercurio, AM Malfitano, F Cianfarani, S Madonna, S Caravella, C Albanesi, E Novellino, D Marasco
    Biochimie, 2017-05-04;0(0):.
    Species: Human
    Sample Types: Recombinant Protein, Whole Cells
    Applications: Bioassay, Surface Plasmon Resonance
  29. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections
    Authors: J Zhang, IM Friberg, A Kift-Morga, G Parekh, MP Morgan, AR Liuzzi, CY Lin, KL Donovan, CS Colmont, PH Morgan, P Davis, I Weeks, DJ Fraser, N Topley, M Eberl
    Kidney Int, 2017-03-17;0(0):.
    Applications: ELISA (Standard)
  30. Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36?
    Authors: JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey
    Proc. Natl. Acad. Sci. U.S.A, 2017-03-13;114(13):E2748-E2757.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
    Authors: Robert Sabat
    Mediators Inflamm., 2016-10-23;2016(0):4097574.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
    J Immunol, 2016-09-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17
    PLoS ONE, 2016-09-02;11(9):e0161759.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Loss of IL-22 inhibits autoantibody formation in collagen-induced arthritis in mice
    Authors: OB Corneth, RM Reijmers, AM Mus, PS Asmawidjaj, JP van Hambur, N Papazian, JY Siegers, F Mourcin, R Amin, K Tarte, RW Hendriks, T Cupedo, E Lubberts
    Eur J Immunol, 2016-05-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis
    PLoS ONE, 2016-05-11;11(5):e0154904.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.
    Authors: Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier R
    J Neuroinflammation, 2015-06-16;12(0):119.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. IL22/IL-22R pathway induces cell survival in human glioblastoma cells.
    Authors: Akil H, Abbaci A, Lalloue F, Bessette B, Costes L, Domballe L, Charreau S, Guilloteau K, Karayan-Tapon L, Bernard F, Morel F, Jauberteau M, Lecron J
    PLoS ONE, 2015-03-20;10(3):e0119872.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. The expression and regulation of chemerin in the epidermis.
    Authors: Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J
    PLoS ONE, 2015-02-06;10(2):e0117830.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vgamma2Vdelta2 T cells after Mycobacterium tuberculosis infection or vaccination.
    Authors: Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, Ryan-Payseur B, Chen Z
    Eur J Immunol, 2015-02-01;45(2):442-51.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
    Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
    Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
    Authors: De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini M, Di Fusco D, Sica G, Sileri P, MacDonald T, Pallone F, Monteleone G, Stolfi C
    Oncogene, 2014-09-01;34(27):3493-503.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M.
    Authors: Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F
    PLoS ONE, 2014-07-10;9(7):e101937.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes.
    Authors: Sakaguchi M, Murata H, Aoyama Y, Hibino T, Putranto E, Ruma I, Inoue Y, Sakaguchi Y, Yamamoto K, Kinoshita R, Futami J, Kataoka K, Iwatsuki K, Huh N
    J Biol Chem, 2014-07-07;289(34):23389-402.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. IL-22 negatively regulates Helicobacter pylori-induced CCL20 expression in gastric epithelial cells.
    Authors: Chen J, Wu M, Kuo S, Liao F
    PLoS ONE, 2014-05-13;9(5):e97350.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members.
    Authors: Beigel F, Friedrich M, Probst C, Sotlar K, Goke B, Diegelmann J, Brand S
    PLoS ONE, 2014-04-07;9(4):e93498.
    Applications: Western Blot
  46. Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses.
    Authors: Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio P, Marasco D, Albanesi C
    Eur J Immunol, 2013-05-28;43(7):1883-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.
    Authors: Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S
    J Immunol, 2013-03-18;190(8):3959-66.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  48. IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients.
    Authors: Pennino D, Bhavsar P, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham S, Cavani A, Eyerich K, Chung K, Schmidt-Weber C, Eyerich S
    J Allergy Clin Immunol, 2012-11-19;131(2):562-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
    Authors: Ramirez-Carrozzi V, Sambandam A, Luis E
    Nat. Immunol., 2011-10-12;12(12):1159-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. TH17 cytokines induce human airway smooth muscle cell migration.
    Authors: Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH
    J. Allergy Clin. Immunol., 2011-02-22;127(4):1046-53.e1-2.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression.
    Authors: Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE
    J. Immunol., 2011-01-17;186(4):2613-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Evidence for altered Wnt signaling in psoriatic skin.
    Authors: Gudjonsson JE, Johnston A, Stoll SW
    J. Invest. Dermatol., 2010-04-08;130(7):1849-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis.
    Authors: Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F
    J. Immunol., 2010-03-24;184(0):5263-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.
    Authors: Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, Husebye ES, Peterson P, Willcox N, Meager A
    J. Exp. Med., 2010-02-01;207(2):299-308.
    Species: Human
    Sample Types: Serum
    Applications: ELISA (Capture)
  55. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
    Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2009-12-01;39(12):3570-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
    Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
    Immunol. Lett., 2009-11-04;127(2):150-6.
    Applications: ELISA (Standard)
  57. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression.
    Authors: Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K
    Eur. J. Immunol., 2009-10-01;39(10):2779-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.
    Authors: Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K
    Genes Immun., 2009-10-01;10(8):702-14.
    Species: Human
    Sample Types: Buffer
    Applications: Bioassay
  59. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
    Authors: Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H
    J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis.
    Authors: Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Zaba LC, Cardinale I, Nograles KE, Khatcherian A, Novitskaya I, Carucci JA, Bergman R, Krueger JG
    J. Immunol., 2008-11-15;181(10):7420-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.
    Authors: Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK
    Nat. Med., 2008-02-10;14(3):275-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. The role of interleukin-22 in hepatitis C virus infection.
    Authors: Dambacher J, Beigel F, Zitzmann K, Heeg MH, Goke B, Diepolder HM, Auernhammer CJ, Brand S
    Cytokine, 2008-01-11;41(3):209-16.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
    Authors: Sa SM, Valdez PA, Wu J
    J. Immunol., 2007-02-15;178(4):2229-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
    Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2006-05-01;36(5):1309-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Reprogramming of IL-10 activity and signaling by IFN-gamma.
    Authors: Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB
    J. Immunol., 2003-11-15;171(10):5034-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

No product specific FAQs exist for this product, however you may

View all Proteins and Enzyme FAQs

Reviews for Recombinant Human IL-22 Protein

There are currently no reviews for this product. Be the first to review Recombinant Human IL-22 Protein and earn rewards!

Have you used Recombinant Human IL-22 Protein?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review