Recombinant Human IL-23 Protein
NEW Next Generation Products! Please try our NEW version of Human Recombinant IL-23 (11349-IL). Combining R&D Systems quality with scalability that allows for lower price points and a solid supply chain.
Recombinant Human IL-23 Protein Summary
Product Specifications
Human IL-23 p40 (Ile23-Ser328) Accession # P29460 |
GSGSSRGGSGSGGSGGGGSKL | Human IL-23 p19 (Arg20-Pro189) Accession # AAG37232 |
N-terminus | C-terminus | |
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
1290-IL
Formulation | Lyophilized from a 0.2 μm filtered solution in MES, NaCl and EDTA with BSA as a carrier protein. |
Reconstitution | Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
1290-IL/CF
Formulation | Supplied as a 0.2 μm filtered solution in MES, NaCl and EDTA. |
Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
Recombinant Human IL-23 (Catalog # 1290-IL) has a molecular weight (MW) of 57.4 kDa as analyzed by SEC-MALS, suggesting that this protein is a heterodimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).
Recombinant Human IL-23 (Catalog # 1290-IL) induces IL-17 secretion by mouse splenocytes. The ED50 is approximately 2-fold better than top competitor. The protein activity is significantly better with nearly twice the max than the top competitor's IL-23.
Reconstitution Calculator
Background: IL-23
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Human p19 cDNA encodes a 189 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 170 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naïve and memory human T cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8- and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.
- Oppmann, B. et al. (2000) Immunity 13:715.
- Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.
- Parham, C. et al. (2002) J. Immunol. 168:5699.
- Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.
- Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.
Citations for Recombinant Human IL-23 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells
Authors: F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber
bioRxiv : the preprint server for biology, 2023-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis
Authors: N Millet, NV Solis, D Aguilar, MS Lionakis, RT Wheeler, N Jendzjowsk, M Swidergall
Nature Communications, 2022-09-22;13(1):5545.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
Authors: AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler
Cells, 2022-08-19;11(16):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis
Authors: M Vitales-No, B Hernández-, D Alvarado-H, L Baranda, S Bernal-Sil, C Abud-Mendo, P Niño-Moren, R González-A
Journal of Immunology Research, 2022-08-13;2022(0):5398743.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation -
An inhibitor of RORgamma for chronic pulmonary obstructive disease treatment
Authors: H Desai, M Marathe, V Potdar, P Tiwari, A Joshi, SR Kadam, AR Joshi, A Kulkarni, V Bhosale, A Hadambar, B Lodhiya, V Udupa, D Behera, SS Chaudhari, S Das, M Bajpai, N Gowda, PS Iyer
Scientific Reports, 2022-05-24;12(1):8744.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Th17-Dependent Nasal Hyperresponsiveness Is Mitigated by Steroid Treatment
Authors: S Ueda, K Miura, H Kawasaki, S Ogata, N Yamasaki, S Miura, A Mori, O Kaminuma
Biomolecules, 2022-05-06;12(5):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
RORgammat phosphorylation protects against T�cell-mediated inflammation
Authors: S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang
Cell Reports, 2022-03-15;38(11):110520.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells
Authors: L Karpf, C Trichot, L Faucheux, I Legbre, M Grandclaud, C Lahoute, H Mattoo, B Pasquier, V Soumelis
Cell Discovery, 2022-01-04;8(1):1.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo
Authors: SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis
PLoS ONE, 2021-11-09;16(11):e0248034.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis
Authors: HK Min, S Kim, JY Lee, KW Kim, SH Lee, HR Kim
Journal of Translational Medicine, 2021-09-16;19(1):392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells
Authors: G Carbotti, B Dozin, S Martini, C Giordano, F Scordamagl, M Croce, G Filaci, S Ferrini, M Fabbi
Cancers, 2021-08-09;13(16):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child
Authors: M Ogishi, R Yang, C Aytekin, D Langlais, M Bourgey, T Khan, FA Ali, M Rahman, OM Delmonte, M Chrabieh, P Zhang, C Gruber, SJ Pelham, AN Spaan, J Rosain, WT Lei, S Drutman, MD Hellmann, MK Callahan, M Adamow, P Wong, JD Wolchok, G Rao, CS Ma, Y Nakajima, T Yaguchi, K Chamoto, SC Williams, JF Emile, F Rozenberg, MS Glickman, F Rapaport, G Kerner, G Allington, I Tezcan, D Cagdas, FO Hosnut, F Dogu, A Ikinciogul, VK Rao, L Kainulaine, V Béziat, J Bustamante, S Vilarinho, RP Lifton, B Boisson, L Abel, D Bogunovic, N Marr, LD Notarangel, SG Tangye, T Honjo, P Gros, S Boisson-Du, JL Casanova
Nature Medicine, 2021-06-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CAR directs T cell adaptation to bile acids in the small intestine
Authors: ML Chen, X Huang, H Wang, C Hegner, Y Liu, J Shang, A Eliason, H Diao, H Park, B Frey, G Wang, SA Mosure, LA Solt, DJ Kojetin, A Rodriguez-, DA Schady, CT Weaver, ME Pipkin, DD Moore, MS Sundrud
Nature, 2021-04-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Conversion of Human Tissue-Like Inflammatory Monocytes Into Macrophages.
Authors: Bsat M, Mehta H, Rubio M, Sarfati M
Curr Protoc, 2021-03-01;1(3):e74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Benefit of Belatacept in Cord Blood-Derived Regulatory T Cell-Mediated Suppression of Alloimmune Response
Authors: X He, S Li, J Zhang, L Cao, C Yang, P Rong, S Yi, K Ghimire, X Ma, W Wang
Cell Transplantation, 2021-01-01;30(0):9636897211046.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
Authors: J Martinez-F, L Wang, E Pohler, A Cozzani, S Wilmes, M Kazemian, S Mitra, I Moraga
Cell Reports, 2020-12-22;33(12):108545.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas
Authors: B Dawod, J Liu, S Gebremeske, C Yan, A Sappong, B Johnston, DW Hoskin, JS Marshall, J Wang
Sci Rep, 2020-08-07;10(1):13343.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
Cell Rep, 2020-06-30;31(13):107820.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A two-step human culture system replicates intestinal monocyte maturation cascade: Conversion of tissue-like inflammatory monocytes into macrophages
Authors: M Bsat, L Chapuy, M Rubio, M Sarfati
Eur. J. Immunol., 2020-06-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
Authors: A Rao, O Strauss, E Kokkinou, M Bruchard, KP Tripathi, H Schlums, A Carrasco, L Mazzurana, V Konya, EJ Villablanc, NK Björkström, U Lindforss, H Spits, J Mjösberg
Nat Commun, 2020-04-27;11(1):2049.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage
Authors: DM Tufa, T Shank, AM Yingst, GD Trahan, S Shim, J Lake, R Woods, K Jones, MR Verneris
Sci Rep, 2020-04-14;10(1):6335.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
Authors: T Mutoh, T Shirai, T Ishii, Y Shirota, F Fujishima, F Takahashi, Y Kakuta, Y Kanazawa, A Masamune, Y Saiki, H Harigae, H Fujii
Nat Commun, 2020-03-09;11(1):1253.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing
Authors: JU Shin, HE Abaci, L Herron, Z Guo, B Sallee, A Pappalardo, J Jackow, EHC Wang, Y Doucet, AM Christiano
Sci Rep, 2020-03-05;10(1):4123.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity
Authors: C Seillet, K Luong, J Tellier, N Jacquelot, RD Shen, P Hickey, VC Wimmer, L Whitehead, K Rogers, GK Smyth, AL Garnham, ME Ritchie, GT Belz
Nat. Immunol., 2019-12-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Data on arsenic trioxide modulates Treg/Th17/Th1/Th2 cells in treatment-na�ve rheumatoid arthritis patients and collagen-induced arthritis model mice
Authors: C Li, J Zhang, W Wang, H Wang, Y Zhang, Z Zhang
Data Brief, 2019-10-15;27(0):104615.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
Authors: JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles
Nat. Immunol., 2019-07-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Juvenile idiopathic arthritis associated with a mutation in GATA3
Authors: AE Patrick, W Wang, E Brokamp, TB Graham, TM Aune, JB Duis
Arthritis Res. Ther., 2019-06-25;21(1):156.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs
Authors: JZ Kawalkowsk, J Ogbechi, PJ Venables, RO Williams
Sci Adv, 2019-05-01;5(5):eaaw5422.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
Eur. J. Immunol., 2019-03-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression
Authors: KC Doh, BM Kim, KW Kim, BH Chung, CW Yang
BMC Complement Altern Med, 2019-03-04;19(1):54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
Nat Commun, 2019-02-12;10(1):709.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease
Authors: L Chapuy, M Bsat, S Sarkizova, M Rubio, A Therrien, E Wassef, M Bouin, K Orlicka, A Weber, N Hacohen, AC Villani, M Sarfati
Mucosal Immunol, 2019-01-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway
Authors: X Xu, C Yang, J Chen, J Liu, P Li, Y Shi, P Yu
Biochem. Biophys. Res. Commun., 2018-03-24;0(0):.
Species: Human
Sample Types: BGC-823 cells
Applications: Bioassay -
IL-23 and IL-1? Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation
Authors: S Revu, J Wu, M Henkel, N Rittenhous, A Menk, GM Delgoffe, AC Poholek, MJ McGeachy
Cell Rep, 2018-03-06;22(10):2642-2653.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials
Authors: H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi
Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen Species Accumulation
Authors: T Zheng, C Xu, C Mao, X Mou, F Wu, X Wang, L Bu, Y Zhou, X Luo, Q Lu, H Liu, G Yuan, S Wang, D Chen, Y Xiao
Front Immunol, 2018-01-29;9(0):96.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway
Authors: F Zhang, G Liu, D Li, C Wei, J Hao
J. Immunol., 2018-01-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rheumatoid arthritis bone marrow environment supports Th17 response.
Authors: Ewa Kuca-Warna, Weronika Kurowska, Monika Prochorec, Anna Radzikows, Tomasz Burakowsk, Urszula Skalska, Magdalena Massalska, Magdalena Pleba?czy, Barbara Ma?dyk-No, Iwona S?owi?ska, Robert Gasik, W?odzimierz Ma?li?ski
Arthritis Research & Therapy, 2017-12-08;0(0):1478-6362.
Species: Human
Sample Types: Plasma
Applications: ELISA (Standard) -
Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation
Authors: YE Bar-Ephrai, F Cornelisse, N Papazian, T Konijn, RM Hoogenboez, MA Sanders, BA Westerman, M Gönültas, J Kwekkeboom, JMM Den Haan, RM Reijmers, RE Mebius, T Cupedo
Cell Rep, 2017-10-17;21(3):823-833.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of ROR?T in human lymphocytes
Authors: A Sa?kowska, K Kara?, A Walczak-Dr, J Dastych, M Ratajewski
J. Leukoc. Biol., 2017-09-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models
Authors: A Steinert, I Linas, B Kaya, M Ibrahim, A Schlitzer, P Hruz, K Radulovic, L Terraccian, AJ Macpherson, JH Niess
J. Immunol., 2017-09-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.
Authors: Yuan Zhang, Chi A Ma, Monica G Lawrence, Timothy J Break, Michael P O'connell, Jonathan J Lyons, Diego B López, John S Barber, Yongge Zhao, Daniel L Barber, Alexandra F Freeman, Steven M Holland, Michail S Lionakis, Joshua D Milner
The Journal of Experimental Medicine, 2017-07-14;0(0):1540-9538.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
J. Immunol., 2017-06-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
Authors: E Forcade, K Paz, R Flynn, B Griesenaue, T Amet, W Li, L Liu, G Bakoyannis, D Jiang, HW Chu, M Lobera, J Yang, DS Wilkes, J Du, K Gartlan, GR Hill, KP MacDonald, EL Espada, P Blanco, JS Serody, J Koreth, CS Cutler, JH Antin, RJ Soiffer, J Ritz, S Paczesny, BR Blazar
JCI Insight, 2017-06-15;2(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Preliminary study of histamine H4 receptor expressed on human CD4(+) T cells and its immunomodulatory potency in the IL-17 pathway of psoriasis
Authors: SH Han, MS Hur, MJ Kim, BM Kim, KW Kim, HR Kim, YB Choe, KJ Ahn, YW Lee
J. Dermatol. Sci., 2017-05-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
Nat. Immunol., 2017-05-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A functional DC cross talk promotes human ILC homeostasis in humanized mice
Authors: S Lopez-Last, G Masse-Rans, O Fiquet, S Darche, N Serafini, Y Li, M Dusséaux, H Strick-Mar, JP Di Santo
Blood Adv, 2017-04-06;1(10):601-614.
Species: Human
Sample Types: Whole Cells
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IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells
Authors: A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May
Blood Adv, 2017-03-30;1(10):577-589.
Species: Human
Sample Types: Whole Cells
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Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates
Authors: MM Shikhagaie, ÅK Björklund, J Mjösberg, JS Erjefält, AS Cornelisse, XR Ros, SM Bal, JJ Koning, RE Mebius, M Mori, M Bruchard, B Blom, H Spits
Cell Rep, 2017-02-14;18(7):1761-1773.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
Front Immunol, 2016-12-23;7(0):603.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Analysis of CXCR5(+)Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis
Sci Rep, 2016-12-22;6(0):39474.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Sci Rep, 2016-12-01;6(0):37977.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia
Authors: I de Weerdt, V van Hoeven, JM Munneke, S Endstra, T Hofland, MD Hazenberg, AP Kater
Haematologica, 2016-08-04;101(11):e461-e464.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism
Stem Cells Transl Med, 2016-07-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor
Authors: Marcin Ratajewski
J Leukoc Biol, 2016-06-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ultraviolet light converts propranolol, a nonselective beta-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand.
Authors: Dorgham K, Amoura Z, Parizot C, Arnaud L, Frances C, Pionneau C, Devilliers H, Pinto S, Zoorob R, Miyara M, Larsen M, Yssel H, Gorochov G, Mathian A
Eur J Immunol, 2015-10-16;45(11):3174-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cooperation between IL-7 Receptor and Integrin alpha2beta1 (CD49b) Drives Th17-Mediated Bone Loss.
Authors: El Azreq M, Arseneault C, Boisvert M, Page N, Allaeys I, Poubelle P, Tessier P, Aoudjit F
J Immunol, 2015-09-25;195(9):4198-209.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin.
Authors: Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, Nakashima T, Kajihara I, Makino K, Makino T, Fukushima S, Ihn H
J Immunol, 2015-09-09;195(8):3565-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.
Authors: Jeffery L, Qureshi O, Gardner D, Hou T, Briggs Z, Soskic B, Baker J, Raza K, Sansom D
PLoS ONE, 2015-07-02;10(7):e0131539.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation.
Authors: Ahn Y, Weeres M, Neulen M, Choi J, Kang S, Heo D, Bergerson R, Blazar B, Miller J, Verneris M
Eur J Immunol, 2015-06-22;45(8):2335-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
Authors: Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A
J Exp Med, 2015-04-27;212(5):619-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
Authors: Tokarski J, Zupa-Fernandez A, Tredup J, Pike K, Chang C, Xie D, Cheng L, Pedicord D, Muckelbauer J, Johnson S, Wu S, Edavettal S, Hong Y, Witmer M, Elkin L, Blat Y, Pitts W, Weinstein D, Burke J
J Biol Chem, 2015-03-11;290(17):11061-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease
Authors: James B Canavan
Gut, 2015-02-24;65(4):584-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vgamma2Vdelta2 T cells after Mycobacterium tuberculosis infection or vaccination.
Authors: Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, Ryan-Payseur B, Chen Z
Eur J Immunol, 2015-02-01;45(2):442-51.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
The role of IL-23/Th17 pathway in patients with primary immune thrombocytopenia.
Authors: Ye X, Zhang L, Wang H, Chen Y, Zhang W, Zhu R, Fang C, Deng A, Qian B
PLoS ONE, 2015-01-26;10(1):e0117704.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1alpha.
Authors: Foucher E, Blanchard S, Preisser L, Descamps P, Ifrah N, Delneste Y, Jeannin P
Eur J Immunol, 2015-01-19;45(4):1092-102.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.
Authors: Scarlata C, Celse C, Pignon P, Ayyoub M, Valmori D
Eur J Immunol, 2015-01-16;45(2):474-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.
Authors: Li H, Richert-Spuhler L, Evans T, Gillis J, Connole M, Estes J, Keele B, Klatt N, Reeves R
PLoS Pathog, 2014-12-11;10(12):e1004551.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation.
Authors: Moore C, Cui Q, Warsi N, Durafourt B, Zorko N, Owen D, Antel J, Bar-Or A
J Immunol, 2014-12-10;194(2):761-72.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay -
B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
Authors: Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L
J Clin Invest, 2014-09-17;124(10):4657-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
PLoS ONE, 2014-09-03;9(9):e106673.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells.
Authors: Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B
J Biol Chem, 2014-07-28;289(37):25546-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A negative feedback loop mediated by STAT3 limits human Th17 responses.
Authors: Purvis H, Anderson A, Young D, Isaacs J, Hilkens C
J Immunol, 2014-06-27;193(3):1142-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.
Authors: Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D
J Immunol, 2014-06-23;193(3):1047-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Combinatorial flexibility of cytokine function during human T helper cell differentiation.
Authors: Touzot M, Grandclaudon M, Cappuccio A, Satoh T, Martinez-Cingolani C, Servant N, Manel N, Soumelis V
Nat Commun, 2014-05-28;5(0):3987.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities.
Authors: Cupi M, Sarra M, Marafini I, Monteleone I, Franze E, Ortenzi A, Colantoni A, Sica G, Sileri P, Rosado M, Carsetti R, MacDonald T, Pallone F, Monteleone G
J Immunol, 2014-05-16;192(12):6083-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
J Clin Invest, 2014-05-08;124(6):2513-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
Authors: Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C
PLoS ONE, 2014-05-02;9(5):e96695.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis.
Authors: Jana M, Mondal S, Jana A, Pahan K
Immunology, 2014-04-01;141(4):549-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.
Authors: Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A, Cheuk S, Brouwer M, Menting S, Eidsmo L, Spits H, Hazenberg M, Mjosberg J
J Invest Dermatol, 2014-03-21;134(9):2351-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.
Authors: Gresnigt M, Bozza S, Becker K, Joosten L, Abdollahi-Roodsaz S, van der Berg W, Dinarello C, Netea M, Fontaine T, De Luca A, Moretti S, Romani L, Latge J, van de Veerdonk F
PLoS Pathog, 2014-03-06;10(3):e1003936.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
Eur J Immunol, 2014-02-18;44(5):1330-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Boswellic acids reduce Th17 differentiation via blockade of IL-1beta-mediated IRAK1 signaling.
Authors: Sturner K, Verse N, Yousef S, Martin R, Sospedra M
Eur J Immunol, 2014-02-16;44(4):1200-12.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.
Authors: Carlson, Thaddeus, Pellerin, Alex, Djuretic, Ivana M, Trivigno, Catherin, Koralov, Sergei B, Rao, Anjana, Sundrud, Mark S
J Immunol, 2014-01-31;192(5):2167-76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.
Authors: Ramesh R, Kozhaya L, McKevitt K, Djuretic I, Carlson T, Quintero M, McCauley J, Abreu M, Unutmaz D, Sundrud M
J Exp Med, 2014-01-06;211(1):89-104.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
Nat Med, 2013-12-22;20(1):62-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
C3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.
Authors: Asgari E, Le Friec G, Yamamoto H, Perucha E, Sacks S, Kohl J, Cook H, Kemper C
Blood, 2013-07-22;122(20):3473-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RORgammat(+) innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44.
Authors: Glatzer T, Killig M, Meisig J, Ommert I, Luetke-Eversloh M, Babic M, Paclik D, Bluthgen N, Seidl R, Seifarth C, Grone J, Lenarz M, Stolzel K, Fugmann D, Porgador A, Hauser A, Karlas A, Romagnani C
Immunity, 2013-06-20;38(6):1223-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue.
Authors: Leung J, Davenport M, Wolff M, Wiens K, Abidi W, Poles M, Cho I, Ullman T, Mayer L, Loke P
Mucosal Immunol, 2013-05-22;7(1):124-33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
Eur J Immunol, 2013-05-08;43(7):1727-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway.
Authors: Chen, Qian, Swaminathan, Sanjay, Yang, De, Dai, Lue, Sui, Hongyan, Yang, Jun, Hornung, Ronald L, Wang, Yanmei, Huang, Da Wei, Hu, Xiaojun, Lempicki, Richard, Imamichi, Tomozumi
PLoS ONE, 2013-03-20;8(3):e59194.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Detection of TCD4+ subsets in human carotid atheroma.
Authors: Oliveira R, Silva R, Teo F, Mineiro M, Ferreira M, Altemani A, Mamoni R, Menezes F, Blotta M
Cytokine, 2013-03-07;62(1):131-40.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8+ memory human T cells.
Authors: Shen H, Zhang W, Abraham C, Cho J
PLoS ONE, 2013-03-01;8(3):e57746.
Species: Human
Sample Types: Whole Blood
Applications: Bioassay -
IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012-09-25;10(9):e1001395.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
Authors: Flanagan K, Fitzgerald K, Baker J
PLoS ONE, 2012-07-06;7(7):e40443.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo.
Authors: Cocco C, Di Carlo E, Zupo S
Leukemia, 2011-12-23;26(6):1365-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD117(+) CD3(-) CD56(-) OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues.
Authors: Kim S, Han S, Withers DR, Gaspal F, Bae J, Baik S, Shin HC, Kim KS, Bekiaris V, Anderson G, Lane P, Kim MY
Eur. J. Immunol., 2011-05-25;41(6):1563-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Authors: El-Behi M, Ciric B, Dai H
Nat. Immunol., 2011-04-24;12(6):568-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis.
Authors: Ramgolam VS, Sha Y, Marcus KL, Choudhary N, Troiani L, Chopra M, Markovic-Plese S
J. Immunol., 2011-03-02;186(0):4518.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans.
Authors: Di Meglio P, Di Cesare A, Laggner U
PLoS ONE, 2011-02-22;6(2):e17160.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis.
Authors: Bowness P, Ridley A, Shaw J
J. Immunol., 2011-01-19;186(0):2672.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
Nat. Med., 2010-01-10;16(2):191-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2009-12-01;39(12):3570-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2009-11-12;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
Immunol. Lett., 2009-11-04;127(2):150-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression.
Authors: Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E
J. Immunol., 2009-11-01;183(9):5494-501.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages.
Authors: Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P
Int. J. Cancer, 2009-07-15;125(2):367-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
Circulation, 2009-03-02;119(10):1424-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC.
Authors: Meyers JA, Mangini AJ, Nagai T, Roff CF, Sehy D, van Seventer JM
Cytokine, 2006-10-18;35(5):235-46.
Species: Human
Sample Types: N/A, Whole Cells
Applications: Bioassay, ELISA (Standard) -
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
Authors: Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henriett, Murphy, Theresa, Murphy, Kenneth, Weaver, Casey T
Nat Immunol, 2005-10-02;6(11):1123-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors.
Authors: Fieschi C, Bosticardo M, de Beaucoudrey L, Boisson-Dupuis S, Feinberg J, Santos OF, Bustamante J, Levy J, Candotti F, Casanova JL
Blood, 2004-06-03;104(7):2095-101.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
FAQs
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Does Recombinant Human IL-23 Protein (Catalog # 1290-IL or Catalog # 1290-IL/CF ) have any tags?
Recombinant Human IL-23 Protein (Catalog # 1290-IL or 1290-IL/CF) does not have any tags. Please refer to the Source section on the product-specific page for sequence information.
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Has Recombinant Human IL-23 Protein (Catalog # 1290-IL or Catalog # 1290-IL/CF) been tested for activity on mouse or non-human primate species?
Recombinant Human IL-23 Protein (Catalog # 1290-IL or 1290-IL/CF) activity is measured by its ability to induce IL-17 secretion by mouse splenocytes. The ED50 for this effect is 0.05-0.3 ng/mL. We have not tested activity of the protein on non-human primate cells in our lab. Please refer the Citations tab to find publications reporting the use of the protein on other species. Filter the results based on species and sample type for a more relevant search to your target species.
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Human IL-23 and Human IL-12 share a p40 subunit. Why is the predicted molecular weight for the p40 subunit 36.5 kDa in the Recombinant Human IL-23 Protein (Catalog # 1290-IL), while the predicted molecular weight for the p40 subunit is 34.7 kDa for the Recombinant Human IL-12 Protein (Catalog # 219-IL)?
The Recombinant Human IL-23 Protein (Catalog # 1290-IL) and Recombinant Human IL-12 Protein (Catalog # 219-IL) p40 subunits share the same p40 sequence, Ile23-Ser328 (Accession # P29460). However, the p40 subunit for Recombinant Human IL-23 (Catalog # 1290-IL) also contains a portion of the GS linker that remains after cleaving p40 subunit from the p19 subunit, so its predicted molecular is slightly larger (36.5 kDa) compared to that of the Recombinant Human IL-12 Protein (Catalog # 219-IL; 34.7 kDa). Please see the product-specific page for detailed sequence information.
Reviews for Recombinant Human IL-23 Protein
Average Rating: 4.5 (Based on 6 Reviews)
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Reason for Rating: high unit concentration, easy to use
We add to our cell culture as a supplement.