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Recombinant Human M-CSF Protein

Catalog #: 216-MC
234 Citations 15 Reviews Datasheet / COA / SDS
Newer Version Available: 216-MCC/CF
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GMP Version Available: 216-GMP
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Analyzed by SEC-MALS, Mammalian-expressed CHO Version Available!

Carrier Free

Catalog # Availability Size / Price Qty
216-MC-005/CF
216-MC-025/CF
216-MC-100/CF
216-MC-010/CF

With Carrier

Catalog # Availability Size / Price Qty
216-MC-005
216-MC-025
216-MC-500
216-MC-01M
216-MC-010
216-MC-100
Recombinant Human M‑CSF Protein SEC-MALS.
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Product Details
Citations (234)
FAQs
Supplemental Products
Reviews (15)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human M-CSF Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. Nakoinz, I. et al. (1990) J. Immunol. 145:860. The ED50 for this effect is 0.5-1.5 ng/mL.
Source
E. coli-derived human M-CSF protein
Glu33-Ser190, with an N-terminal Met
Accession #
NP_757350
N-terminal Sequence
Analysis
Met
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
18.5 kDa (monomer)
SDS-PAGE
37 kDa, non-reducing conditions

Product Datasheets

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216-MC (with carrier)

Product Datasheet
COA
SDS

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216-MC/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

216-MC

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50-500 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

216-MC/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 50-500 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

SEC-MALS View Larger

Recombinant human M-CSF (Catalog # 216-MC) has a molecular weight (MW) of 39.2 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Bioactivity Recombinant Human M-CSF Protein Bioactivity View Larger

Recombinant Human M-CSF (Catalog # 216-MC) stimulates cell proliferation of the M‑NFS‑60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner. The ED50 for this effect is 0.5-1.5 ng/mL.

SDS-PAGE Recombinant Human M-CSF Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human M-CSF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing bands at 19 kDa and 35 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: M-CSF

M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1-3). M-CSF is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta (5). Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells (1-5). The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur (3-9). Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen (8). Shorter transcripts encode
M‑CSF that lacks cleavage and PG sites and produces an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7). Although forms may vary in activity and half-life, all contain the N‑terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor (10, 11). The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M‑CSF, respectively (12, 13). Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

References
  1. Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
  2. Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
  3. Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
  4. Ryan, G.R. et al. (2001) Blood 98:74.
  5. Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
  6. Nandi, S. et al. (2006) Blood 107:786.
  7. Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
  8. Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
  9. Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
  10. Koths, K. (1997) Mol. Reprod. Dev. 46:31.
  11. Jang, M-H. et al. (2006) J. Immunol. 177:4055.
  12. Kawasaki, E.S. et al. (1985) Science 230: 291.
  13. Wong, G.G. et al. (1987) Science 235:1504.
Long Name
Macrophage Colony Stimulating Factor
Entrez Gene IDs
1435 (Human); 12977 (Mouse)
Alternate Names
colony stimulating factor 1 (macrophage); CSF1; CSF-1; Lanimostim; macrophage colony stimulating factor; macrophage colony-stimulating factor 1; MCSF; M-CSF; MCSFlanimostim; MGC31930

Citations for Recombinant Human M-CSF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

234 Citations: Showing 1 - 10
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  1. TIM-3 Expression and M2 Polarization of Macrophages in the TGF?-Activated Tumor Microenvironment in Colorectal Cancer
    Authors: Katagata, M;Okayama, H;Nakajima, S;Saito, K;Sato, T;Sakuma, M;Fukai, S;Endo, E;Sakamoto, W;Saito, M;Saze, Z;Momma, T;Mimura, K;Kono, K;
    Cancers
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination
    Authors: Duran-Castells, C;Prats, A;Oriol-Tordera, B;Llano, A;Galvez, C;Martinez-Picado, J;Ballana, E;Garcia-Vidal, E;Clotet, B;Muñoz-Moreno, JA;Hanke, T;Moltó, J;Mothe, B;Brander, C;Ruiz-Riol, M;
    EBioMedicine
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice
    Authors: G Yi, F Yang, A Labani-Mot, JD Moreira, D Ansari, JA Bohorquez, S Patel, F Spagnolo, J Florence, A Vankayalap, R Vankayalap, JJDJ Dennehy, B Samten
    bioRxiv : the preprint server for biology, 2023-02-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma
    Authors: Y Kitamura, YI Koma, K Tanigawa, S Tsukamoto, Y Azumi, S Miyako, S Urakami, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki
    Cancers, 2023-01-06;15(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses
    Authors: L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy
    Viruses, 2022-12-29;15(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model
    Authors: J Pape, D Bakkalci, RA Hosni, BS Simpson, K Heikinheim, S Fedele, U Cheema
    Journal of tissue engineering, 2022-12-24;13(0):2041731422114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. The release of osteoclast-stimulating factors on supraphysiological loading by osteoprogenitors coincides with expression of genes associated with inflammation and cytoskeletal arrangement
    Authors: C Bratengeie, AD Bakker, A Liszka, J Schilcher, A Fahlgren
    Scientific Reports, 2022-12-14;12(1):21578.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  8. Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis
    Authors: R Boland, MT Heemskerk, G Forn-Cuní, CJ Korbee, KV Walburg, JJ Esselink, C Carvalho D, AM de Waal, DCM van der Ho, E van der Sa, AS de Ries, J Xie, HP Spaink, M van der Va, MC Haks, AH Meijer, THM Ottenhoff
    MBio, 2022-12-07;0(0):e0302422.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism
    Authors: Y Hou, D Wei, Z Zhang, H Guo, S Li, J Zhang, P Zhang, L Zhang, Y Zhao
    Cell Reports, 2022-11-15;41(7):111668.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption
    Authors: D Ding, L Wang, J Yan, Y Zhou, G Feng, L Ma, Y Yang, X Pei, Q Jin
    PLoS ONE, 2022-07-28;17(7):e0271485.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  11. The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages
    Authors: AM Soileau, CN Quick, CE Moeller, JC Schaumburg, SS Withers
    Oncogene, 2022-07-21;9(7):.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  12. TIRAP/Mal Positively Regulates TLR8-Mediated Signaling via IRF5 in Human Cells
    Authors: KE Nilsen, A Skjesol, J Frengen Ko, T Espevik, J Stenvik, M Yurchenko
    Oncogene, 2022-06-22;10(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice
    Authors: S Lin, A Zhang, L Yuan, Y Wang, C Zhang, J Jiang, H Xu, H Yuan, H Yao, Q Zhang, Y Zhang, M Lou, P Wang, ZN Zhang, B Luan
    Nature Communications, 2022-06-08;13(1):3301.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. A multispecific anti-CD40 DARPin� construct induces tumor-selective CD40 activation and tumor regression
    Authors: N Rigamonti, N Veitonmäki, C Domke, S Barsin, S Jetzer, O Abdelmotal, R Bessey, T Lekishvili, F Malvezzi, M Gachechila, M Béhé, V Levitsky, PA Trail
    Cancer Immunology Research, 2022-05-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. The Crohn Disease-associated ATG16L1T300A polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling
    Authors: P Gao, H Liu, H Huang, Y Sun, B Jia, B Hou, X Zhou, W Strober, F Zhang
    Autophagy, 2022-02-27;0(0):1-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells
    Authors: X Wang, Y Chen, B Lan, Y Wang, W Lin, X Jiang, J Ye, B Shang, C Feng, J Liu, J Zhai, M Xu, Q Li, L Lin, M Hu, F Zheng, L Chen, C Shao, Y Wang, Y Shi
    Theranostics, 2022-01-31;12(5):2063-2079.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Bacterial infections exacerbate myeloma bone disease
    Authors: R Liu, Y Zhong, R Chen, S Chen, Y Huang, H Liu
    Journal of Translational Medicine, 2022-01-06;20(1):16.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension
    Authors: PL Chi, CC Cheng, CC Hung, MT Wang, HY Liu, MW Ke, MC Shen, KC Lin, SH Kuo, PP Hsieh, SR Wann, WC Huang
    International journal of biological sciences, 2022-01-01;18(1):331-348.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-kappaB/ERK signaling pathway
    Authors: H Guo, D Ding, L Wang, J Yan, L Ma, Q Jin
    PLoS ONE, 2021-12-16;16(12):e0261127.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment
    Authors: Q Xu, P Zhan, X Li, F Mo, H Xu, Y Liu, Q Lai, B Zhang, M Dai, X Liu
    Journal of Cellular and Molecular Medicine, 2021-10-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses
    Authors: M Zhao, Y Zhang, X Yang, J Jin, Z Shen, X Feng, T Zou, L Deng, D Cheng, X Zhang, C Qin, C Niu, Z Ye, X Zhang, J He, C Hou, G Li, G Han, Q Cheng, Q Wang, L Wei, J Dong, J Zhang
    PloS Pathogens, 2021-09-10;17(9):e1009901.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions
    Authors: D Zhang, J Huang, F Wang, H Ding, Y Cui, Y Yang, J Xu, H Luo, Y Gao, L Pan, Y Wu, Y Gong, L Xie, Z Liu, Y Qu, L Zhang, W Liu, W Zhang, S Zhao, Q Yi, T Niu, Y Zheng
    Cell Death & Disease, 2021-05-15;12(5):495.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
    Authors: M Zelic, F Pontarelli, L Woodworth, C Zhu, A Mahan, Y Ren, M LaMorte, R Gruber, A Keane, P Loring, L Guo, TH Xia, B Zhang, P Orning, E Lien, A Degterev, T Hammond, D Ofengeim
    Cell Reports, 2021-05-11;35(6):109112.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
    Authors: R Song, Y Gao, I Dozmorov, V Malladi, I Saha, MM McDaniel, S Parameswar, C Liang, C Arana, B Zhang, B Wakeland, J Zhou, MT Weirauch, LC Kottyan, EK Wakeland, C Pasare
    Cell Reports, 2021-03-23;34(12):108891.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Impairment in inflammasome signaling by the chronic Pseudomonas aeruginosa isolates from cystic fibrosis patients results in an increase in inflammatory response
    Authors: MS Phuong, RE Hernandez, DJ Wolter, LR Hoffman, S Sad
    Cell Death & Disease, 2021-03-04;12(3):241.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Anti-Tyro3 IgG Associates with Disease Activity and Reduces Efferocytosis of Macrophages in New-Onset Systemic Lupus Erythematosus
    Authors: Z Zhou, A Xu, J Teng, F Wang, Y Tan, H Liu, X Cheng, Y Su, H Shi, Q Hu, H Chi, J Li, J Hou, Y Sun, C Yang, J Ye
    J Immunol Res, 2020-11-10;2020(0):2180708.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  27. Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.
    Authors: Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill L, Gonzalez-Rivera I, Buchanan F, Prescott A, Faust D, Fox S, Brownlees J, Taylor D, Perry V, Nuthall H, Atkinson P, Karran E, Routledge C, Gomez-Nicola D
    Front Immunol, 2020-10-08;11(0):579000.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  28. SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
    Authors: D Olagnier, E Farahani, J Thyrsted, J Blay-Cadan, A Herengt, M Idorn, A Hait, B Hernaez, A Knudsen, MB Iversen, M Schilling, SE Jørgensen, M Thomsen, LS Reinert, M Lappe, HD Hoang, VH Gilchrist, AL Hansen, R Ottosen, CG Nielsen, C Møller, D van der Ho, S Peri, S Balachandr, J Huang, M Jakobsen, EB Svenningse, TB Poulsen, L Bartsch, AL Thielke, Y Luo, T Alain, J Rehwinkel, A Alcamí, J Hiscott, TH Mogensen, SR Paludan, CK Holm
    Nat Commun, 2020-10-02;11(1):4938.
    Species: Human
    Sample Types: Serum
    Applications: Cell Culture
  29. Lupeol Counteracts the Proinflammatory Signalling Triggered in Macrophages by 7-Keto-Cholesterol: New Perspectives in the Therapy of Atherosclerosis
    Authors: S Saha, E Profumo, AR Togna, R Riganò, L Saso, B Buttari
    Oxid Med Cell Longev, 2020-09-27;2020(0):1232816.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
    Authors: F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen
    Res Sq, 2020-09-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure
    Authors: KJ Gregory, SM Morin, A Kubosiak, J Ser-Dolans, B Schalet, DJ Jerry, SS Schneider
    Immunol. Cell Biol., 2020-09-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  32. Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair
    Authors: FM Davis, LC Tsoi, R Wasikowski, A denDekker, A Joshi, C Wilke, H Deng, S Wolf, A Obi, S Huang, AC Billi, S Robinson, J Lipinski, WJ Melvin, CO Audu, S Weidinger, SL Kunkel, A Smith, JE Gudjonsson, BB Moore, KA Gallagher
    JCI Insight, 2020-09-03;5(17):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. &beta-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies
    Authors: G Camilli, M Bohm, AC Piffer, R Lavenir, DL Williams, B Neven, G Grateau, S Georgin-La, J Quintin
    J. Clin. Invest., 2020-09-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  34. Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials
    Authors: S Vakili, TM Ahooyi, SS Yarandi, M Donadoni, J Rappaport, IK Sariyer
    Brain Sci, 2020-07-03;10(7):.
    Species: Human
    Sample Types: Whole Cells
  35. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
    Authors: M Yin, Y Guo, R Hu, WL Cai, Y Li, S Pei, H Sun, C Peng, J Li, R Ye, Q Yang, N Wang, Y Tao, X Chen, Q Yan
    Nat Commun, 2020-04-14;11(1):1833.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting &beta Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice
    Authors: J Xue, Y Cheng, H Hao, J Gao, Y Yin, S Yu, J Zou, J Liu, Q Zhang, Y Mu
    Stem Cells Int, 2020-04-03;2020(0):4689798.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model
    Authors: B Moukengue, HK Brown, C Charrier, S Battaglia, M Baud'huin, T Quillard, TM Pham, IS Pateras, VG Gorgoulis, T Helleday, D Heymann, UW Berglund, B Ory, F Lamoureux
    EBioMedicine, 2020-03-07;53(0):102704.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages
    Authors: J Lubow, MC Virgilio, M Merlino, DR Collins, M Mashiba, BG Peterson, Z Lukic, MM Painter, F Gomez-Rive, V Terry, G Zimmerman, KL Collins
    Elife, 2020-03-02;9(0):.
    Species: Human
    Sample Types: Leukocytes
    Applications: Bioassay
  40. Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block
    Authors: V Sharma, M Makhdoomi, L Singh, P Kumar, N Khan, S Singh, HN Verma, K Luthra, S Sarkar, D Kumar
    Autophagy, 2020-02-20;0(0):1-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis
    Authors: KA Lee, KW Kim, BM Kim, JY Won, HK Min, DW Lee, HR Kim, SH Lee
    Arthritis Res. Ther., 2019-12-12;21(1):283.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. NKL homeobox gene activities in normal and malignant myeloid cells
    Authors: S Nagel, M Scherr, RAF MacLeod, C Pommerenke, M Koeppel, C Meyer, M Kaufmann, I Dallmann, HG Drexler
    PLoS ONE, 2019-12-11;14(12):e0226212.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Profiles of Long Non-Coding RNAs and mRNA Expression in Human Macrophages Regulated by Interleukin-27
    Authors: X Hu, S Goswami, J Qiu, Q Chen, S Laverdure, BT Sherman, T Imamichi
    Int J Mol Sci, 2019-12-09;20(24):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions
    Authors: N Chiang, S Libreros, PC Norris, X de la Rosa, CN Serhan
    J. Clin. Invest., 2019-12-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  46. Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
    Authors: N Berges, MS Nawaz, T Børresdatt, L Hagen, M Bjørås, JK Laerdahl, I Alseth
    PLoS ONE, 2019-11-08;14(11):e0225081.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  47. MiRNA-483-5p is involved in the pathogenesis of osteoporosis by promoting osteoclast differentiation
    Authors: K Li, S Chen, P Cai, K Chen, L Li, X Yang, J Yi, X Luo, Y Du, H Zheng
    Mol. Cell. Probes, 2019-11-06;0(0):101479.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  48. Differed IL-1 Beta Response between Active TB and LTBI Cases by Ex Vivo Stimulation of Human Monocyte-Derived Macrophage with TB-Specific Antigen
    Authors: MR Lee, LY Chang, CH Chang, BS Yan, JY Wang, WH Lin
    Dis. Markers, 2019-10-29;2019(0):7869576.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  49. CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
    Authors: R Xu, Y Li, H Yan, E Zhang, X Huang, Q Chen, J Chen, J Qu, Y Liu, J He, Q Yi, Z Cai
    Cell Death Dis, 2019-10-14;10(10):781.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. HIF1alpha inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
    Authors: C Liang, J Li, C Lu, D Xie, J Liu, C Zhong, X Wu, R Dai, H Zhang, D Guan, B Guo, B He, F Li, X He, W Zhang, BT Zhang, G Zhang, A Lu
    Nat Commun, 2019-10-08;10(1):4579.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
    Authors: S Gooding, SWZ Olechnowic, EV Morris, AE Armitage, J Arezes, J Frost, E Repapi, JR Edwards, N Ashley, C Waugh, N Gray, E Martinez-H, PJ Lim, SR Pasricha, H Knowles, AJ Mead, K Ramasamy, H Drakesmith, CM Edwards
    Nat Commun, 2019-10-04;10(1):4533.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP)
    Authors: Y Zhao, X Ni, P Xu, Q Liu, T Sun, X Liu, X Ji, J Qiu, J Li, S Wang, P Han, J Peng, M Hou, G Li
    Cytokine, 2019-09-23;125(0):154853.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Insight into the Antifungal Mechanism of Action of Human RNase N-terminus Derived Peptides
    Authors: VA Salazar, J Arranz-Tru, G Prats-Ejar, M Torrent, D Andreu, D Pulido, E Boix
    Int J Mol Sci, 2019-09-14;20(18):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs
    Authors: W Wheat, L Chow, A Kuzmik, S Soontarara, J Kurihara, M Lappin, S Dow
    BMC Vet. Res., 2019-09-13;15(1):330.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  55. NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1 β response and host susceptibility
    Authors: MF Wu, CC Shu, JY Wang, BS Yan, HC Lai, BL Chiang, LS Wu, CJ Yu
    Sci Rep, 2019-08-29;9(1):12534.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
    Authors: P R Andrade, M Mehta, J Lu, R M B Teles, D Montoya, P O Scumpia, E Nunes Sarn, MT Ochoa, F Ma, M Pellegrini, RL Modlin
    PLoS Negl Trop Dis, 2019-07-25;13(7):e0007589.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels
    Authors: FL Collins, MD Stone, J Turton, LR McCabe, ECY Wang, AS Williams
    BMC Musculoskelet Disord, 2019-07-12;20(1):326.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Impact of Periprosthetic Fibroblast-Like Cells on Osteoclastogenesis in Co-Culture with Peripheral Blood Mononuclear Cells Varies Depending on Culture System
    Authors: MI Koehler, ES Hartmann, S Schluessel, F Beck, JI Redeker, B Schmitt, M Unger, M van Griens, B Summer, A Fottner, S Mayer-Wagn
    Int J Mol Sci, 2019-05-26;20(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins
    Authors: E Braun, D Hotter, L Koepke, F Zech, R Gro beta, KMJ Sparrer, JA Müller, CK Pfaller, E Heusinger, R Wombacher, K Sutter, U Dittmer, M Winkler, G Simmons, MR Jakobsen, KK Conzelmann, S Pöhlmann, J Münch, OT Fackler, F Kirchhoff, D Sauter
    Cell Rep, 2019-05-14;27(7):2092-2104.e10.
    Species: Human
    Sample Types: cell culture
    Applications: cell differentiation
  60. miR-146b level and variants is associated with endometriosis related macrophages phenotype and plays a pivotal role in the endometriotic pain symptom
    Authors: Z Zhang, H Li, Z Zhao, B Gao, L Meng, X Feng
    Taiwan J Obstet Gynecol, 2019-05-01;58(3):401-408.
    Species: Human
    Sample Types: PBMCs
    Applications: Bioassay
  61. IL-26 contributes to host defense against intracellular bacteria
    Authors: AT Dang, RM Teles, DI Weiss, K Parvatiyar, EN Sarno, MT Ochoa, G Cheng, M Gilliet, BR Bloom, RL Modlin
    J. Clin. Invest., 2019-04-02;129(5):1926-1939.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response
    Authors: DJ Montoya, P Andrade, BJA Silva, RMB Teles, F Ma, B Bryson, S Sadanand, T Noel, J Lu, E Sarno, KB Arnvig, D Young, R Lahiri, DL Williams, S Fortune, BR Bloom, M Pellegrini, RL Modlin
    Cell Rep, 2019-03-26;26(13):3574-3585.e3.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
    Authors: A Skjesol, M Yurchenko, K Bösl, C Gravastran, KE Nilsen, LM Grøvdal, F Agliano, F Patane, G Lentini, H Kim, G Teti, A Kumar Shar, RK Kandasamy, B Sporsheim, KK Starheim, DT Golenbock, H Stenmark, M McCaffrey, T Espevik, H Husebye
    PLoS Pathog., 2019-03-18;15(3):e1007684.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis
    Authors: S Ashraf, M Radhi, P Gowler, JJ Burston, RD Gandhi, GJ Thorn, AM Piccinini, DA Walsh, V Chapman, CH de Moor
    Sci Rep, 2019-03-18;9(1):4696.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. HSP70 is a negative regulator of NLRP3 inflammasome activation
    Authors: P Martine, A Chevriaux, V Derangère, L Apetoh, C Garrido, F Ghiringhel, C Rébé
    Cell Death Dis, 2019-03-15;10(4):256.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells
    Authors: F De Santis, N Poerio, A Gismondi, V Nanni, G Di Marco, R Nisini, MC Thaller, A Canini, M Fraziano
    PLoS ONE, 2019-03-04;14(3):e0213150.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro
    Authors: H Löfvall, A Katri, A D?browska, MA Karsdal, Y Luo, Y He, T Manon-Jens, MH Dziegiel, AC Bay-Jensen, CS Thudium, K Henriksen
    Sci Rep, 2019-02-28;9(1):3050.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes
    Authors: F Beck, ES Hartmann, MI Koehler, JI Redeker, S Schluessel, B Schmitt, A Fottner, M Unger, M van Griens, J Michael, B Summer, KH Kunzelmann, R Beutner, D Scharnwebe, PJ Kostenuik, S Mayer-Wagn
    Int J Mol Sci, 2019-02-26;20(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery
    Authors: W Ren, J Hou, C Yang, H Wang, S Wu, Y Wu, X Zhao, C Lu
    J. Exp. Clin. Cancer Res., 2019-02-08;38(1):62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways
    Authors: X Rao, S Zhao, Z Braunstein, H Mao, M Razavi, L Duan, Y Wei, AC Toomey, S Rajagopala, J Zhong
    EBioMedicine, 2019-02-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. G-CSF-induced macrophage polarization and mobilization may prevent acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    Authors: Q Wen, Y Kong, HY Zhao, YY Zhang, TT Han, Y Wang, LP Xu, XH Zhang, XJ Huang
    Bone Marrow Transplant., 2019-01-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection
    Authors: Y Zhang, T Tada, S Ozono, W Yao, M Tanaka, S Yamaoka, S Kishigami, H Fujita, K Tokunaga
    J. Biol. Chem., 2019-01-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
    Authors: T Plitnik, ME Sharkey, B Mahboubi, B Kim, M Stevenson
    Pathog Immun, 2018-12-06;3(2):197-223.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Long-term effectiveness of local BM-MSCs for skeletal muscle regeneration: a proof of concept obtained on a pig model of severe radiation burn
    Authors: C Linard, M Brachet, B L'homme, C Strup-Perr, E Busson, M Bonneau, JJ Lataillade, E Bey, M Benderitte
    Stem Cell Res Ther, 2018-11-08;9(1):299.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Transfection of Peripheral Blood Monocytes with SOX2 Enhances Multipotency, Proliferation, and Redifferentiation into Neohepatocytes and Insulin-Producing Cells
    Authors: A Hyder, S Ehnert, F Fändrich, H Ungefroren
    Stem Cells Int, 2018-10-04;2018(0):4271875.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Peripheral blood monocytes show increased osteoclast differentiation potential compared to bone marrow monocytes
    Authors: E Kylmäoja, M Nakamura, S Turunen, C Patlaka, G Andersson, P Lehenkari, J Tuukkanen
    Heliyon, 2018-09-12;4(9):e00780.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Septins are critical regulators of osteoclastic bone resorption
    Authors: AMJ Møller, EM Füchtbauer, A Brüel, TL Andersen, XG Borggaard, NJ Pavlos, JS Thomsen, FS Pedersen, JM Delaisse, K Søe
    Sci Rep, 2018-08-29;8(1):13016.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Translational Biomarkers and Ex Vivo Models of Joint Tissues as a Tool for Drug Development in Rheumatoid Arthritis
    Authors: CF Kjelgaard-, A Platt, M Braddock, MA Jenkins, K Musa, E Graham, T Gantzel, G Slynn, ME Weinblatt, MA Karsdal, CS Thudium, AC Bay-Jensen
    Arthritis & rheumatology (Hoboken, N.J.), 2018-07-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  79. GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Beh�et's disease
    Authors: H Nakano, Y Kirino, M Takeno, K Higashitan, H Nagai, R Yoshimi, Y Yamaguchi, I Kato, I Aoki, H Nakajima
    Arthritis Res. Ther., 2018-06-12;20(1):124.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation
    Authors: K Matsuoka, Y Kohara, Y Naoe, A Watanabe, M Ito, K Ikeda, S Takeshita
    J. Bone Miner. Res., 2018-05-11;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.
    Authors: Maria J Forteza, Konstantinos A Polyzos, Roland Baumgartn, Bianca E Suur, Marion Mussbache, Daniel K Johansson, Andreas Hermansso, Göran K Hansson, Daniel F J Ketelhuth
    Frontiers in Immunology, 2018-05-07;0(0):1664-3224.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach
    Authors: R Berndt, L Hummitzsch, K He beta, M Albrecht, K Zitta, R Rusch, B Sarras, A Bayer, J Cremer, F Faendrich, J Gro beta
    Stem Cell Res Ther, 2018-04-27;9(1):117.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Improved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern
    Authors: N Fournier, E Jacque, A Fontayne, D Derache, G Dupont, L Verhaeghe, L Baptista, A Dehenne, AS Dezetter, A Terrier, A Longue, V Pochet-Beg, C Beghin, S Chtourou, C de Romeuf
    MAbs, 2018-04-10;0(0):1-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons
    Authors: D Kishimoto, Y Kirino, M Tamura, M Takeno, Y Kunishita, K Takase-Min, H Nakano, I Kato, K Nagahama, R Yoshimi, K Igarashi, I Aoki, H Nakajima
    Arthritis Res. Ther., 2018-04-10;20(1):64.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Tat controls transcriptional persistence of unintegrated HIV genome in primary human macrophages
    Authors: B Meltzer, D Dabbagh, J Guo, F Kashanchi, M Tyagi, Y Wu
    Virology, 2018-03-15;518(0):241-252.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene
    Authors: J Costa-Rodr, MH Fernandes, O Pinho, PRR Monteiro
    J. Nutr. Biochem., 2018-03-15;57(0):26-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes
    Authors: X Jin, H Xu, MS McGrath
    PLoS ONE, 2018-03-14;13(3):e0192680.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production
    Authors: M Viaud, S Ivanov, N Vujic, M Duta-Mare, LE Aira, T Barouillet, E Garcia, F Orange, I Dugail, I Hainault, C Stehlik, S Marchetti, L Boyer, R Guinamard, F Foufelle, AE Bochem, KG Hovingh, EB Thorp, EL Gautier, D Kratky, PA Da Silva-J, L Yvan-Charv
    Circ. Res., 2018-03-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Infection of monocytes with European porcine reproductive and respiratory syndrome virus (PRRSV-1) strain Lena is significantly enhanced by dexamethasone and IL-10
    Authors: H Singleton, SP Graham, JP Frossard, KB Bodman-Smi, F Steinbach
    Virology, 2018-03-02;0(0):.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1
    Authors: T Prabakaran, C Bodda, C Krapp, BC Zhang, MH Christense, C Sun, L Reinert, Y Cai, SB Jensen, MK Skouboe, JR Nyengaard, CB Thompson, RJ Lebbink, GC Sen, G van Loo, R Nielsen, M Komatsu, LN Nejsum, MR Jakobsen, M Gyrd-Hanse, SR Paludan
    EMBO J., 2018-03-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. HIF1?-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection
    Authors: C Li, Y Wang, Y Li, Q Yu, X Jin, X Wang, A Jia, Y Hu, L Han, J Wang, H Yang, D Yan, Y Bi, G Liu
    Sci Rep, 2018-02-26;8(1):3603.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages
    Authors: M Yurchenko, A Skjesol, L Ryan, GM Richard, RK Kandasamy, N Wang, C Terhorst, H Husebye, T Espevik
    J. Cell Biol., 2018-02-12;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Differentiation, Differentiation
  93. SWAP70 is a universal GEF-like adapter for tethering actin to phagosomes
    Authors: MV Baranov, NH Revelo, DRJ Verboogen, M Ter Beest, G van den Bo
    Small GTPases, 2018-02-09;0(0):0.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
    Authors: CJ Korbee, MT Heemskerk, D Kocev, E van Strije, O Rabiee, KLMC Franken, L Wilson, NDL Savage, S Džeroski, MC Haks, THM Ottenhoff
    Nat Commun, 2018-01-24;9(1):358.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors
    Authors: SP Mukherjee, O Bondarenko, P Kohonen, FT Andón, T Brzicová, I Gessner, S Mathur, M Bottini, P Calligari, L Stella, E Kisin, A Shvedova, R Autio, H Salminen-M, R Lahesmaa, B Fadeel
    Sci Rep, 2018-01-18;8(1):1115.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. A glucose-responsive insulin therapy protects animals against hypoglycemia
    Authors: R Yang, M Wu, S Lin, RP Nargund, X Li, T Kelly, L Yan, G Dai, Y Qian, Q Dallas-Yan, PA Fischer, Y Cui, X Shen, P Huo, DD Feng, MD Erion, DE Kelley, J Mu
    JCI Insight, 2018-01-11;3(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms
    Authors: T Do, R Tan, M Bennett, M Medvedovic, AA Grom, N Shen, S Thornton, GS Schulert
    J. Leukoc. Biol., 2017-12-29;103(1):71-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Cathepsin K Localizes to Equine Boneand Inhibits Bone Marrow Stem and Progenitor Cells Differentiation
    Authors: H Hussein, P Boyaka, J Dulin, D Russell, L Smanik, M Azab, AL Bertone
    J Stem Cells Regen Med, 2017-12-18;13(2):45-53.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies
    Authors: M Kostine, IH Briaire-de, AHG Cleven, C Vervat, WE Corver, MW Schilham, E Van Beelen, H van Boven, RL Haas, A Italiano, AM Cleton-Jan, JVMG Bovée
    Oncoimmunology, 2017-10-26;7(2):e1386828.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  100. Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus
    Authors: H Di, JC Madden, EK Morantz, HY Tang, RL Graham, RS Baric, MA Brinton
    Proc. Natl. Acad. Sci. U.S.A., 2017-10-04;114(42):E8895-E8904.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Bioassay
  101. CLEC5A is a critical receptor in innate immunity against Listeria infection
    Authors: ST Chen, FJ Li, TY Hsu, SM Liang, YC Yeh, WY Liao, TY Chou, NJ Chen, M Hsiao, WB Yang, SL Hsieh
    Nat Commun, 2017-08-21;8(1):299.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides
    Authors: L Stenberg, M Stö beta el, G Ronchi, S Geuna, Y Yin, S Mommert, L Mårtensson, J Metzen, C Grothe, LB Dahlin, K Haastert-T
    BMC Neurosci, 2017-07-18;18(1):53.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. HIV and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathways
    Authors: N Gajanayaka, S O'Hara, Y Konarski, J Fernandes, K Muthumani, M Kozlowski, JB Angel, A Kumar
    J. Leukoc. Biol., 2017-07-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Semen amyloids participate in spermatozoa selection and clearance
    Authors: NR Roan, N Sandi-Monr, N Kohgadai, SM Usmani, KG Hamil, J Neidleman, M Montano, L Ständker, A Röcker, M Cavrois, J Rosen, K Marson, JF Smith, CD Pilcher, F Gagsteiger, O Sakk, M O'Rand, PV Lishko, F Kirchhoff, J Münch, WC Greene
    Elife, 2017-06-27;6(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells
    Authors: A Sucur, Z Jajic, M Artukovic, MI Matijasevi, B Anic, D Flegar, A Markotic, T Kelava, S Ivcevic, N Kovacic, V Katavic, D Grcevic
    Arthritis Res. Ther., 2017-06-15;19(1):142.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts
    Authors: EL Stattin, P Henning, J Klar, E McDermott, C Stecksen-B, PE Sandström, TG Kellgren, P Rydén, G Hallmans, T Lönnerholm, A Ameur, MH Helfrich, FP Coxon, N Dahl, J Wikström, UH Lerner
    Sci Rep, 2017-06-07;7(1):3012.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-Like receptor agonists
    Authors: S Vollmer, S Strickson, T Zhang, N Gray, K Lee, V Rao, P Cohen
    Biochem. J., 2017-06-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Hypoxia-Inducible Factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2
    Authors: PA Hulley, T Bishop, A Vernet, JE Schneider, JR Edwards, NA Athanasou, HJ Knowles
    J. Pathol., 2017-05-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Time-lapse reveals that osteoclasts can move across the bone surface while resorbing
    Authors: K Søe, JM Delaissé
    J. Cell. Sci., 2017-05-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity
    Authors: G Chinetti-G, M Daoudi, M Rosa, M Vinod, L Louvet, C Copin, M Fanchon, J Vanhoutte, B Derudas, L Belloy, S Haulon, C Zawadzki, S Susen, ZA Massy, J Eeckhoute, B Staels
    Circ. Res., 2017-04-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan
    Authors: A Kamalakar, CL Washam, NS Akel, BJ Allen, DK Williams, FL Swain, K Leitzel, A Lipton, D Gaddy, LJ Suva
    J. Bone Miner. Res., 2017-04-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity
    Authors: KJ Chung, A Chatzigeor, M Economopou, R Garcia-Mar, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, J Phieler, JH Lim, KP Karalis, T Papayannop, M Blüher, G Hajishenga, T Chavakis
    Nat. Immunol., 2017-04-17;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Imaging HIV-1 Genomic DNA from Entry through Productive Infection
    Authors: RD Stultz, JJ Cenker, D McDonald
    J. Virol, 2017-04-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification
    Authors: S Petruk, SA Mariani, M De Dominic, P Porazzi, V Minieri, J Cai, L Iacovitti, N Flomenberg, B Calabretta, A Mazo
    Cell Rep, 2017-04-11;19(2):295-306.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network
    Authors: AJ Martins, M Narayanan, T Prüstel, B Fixsen, K Park, RA Gottschalk, Y Lu, C Andrews-Pf, WW Lau, KV Wendelsdor, JS Tsang
    Cell Syst, 2017-03-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity
    Authors: DC Thomas, S Clare, JM Sowerby, M Pardo, JK Juss, DA Goulding, L van der We, D Storistean, A Prakash, M Espéli, S Flint, JC Lee, K Hoenderdos, L Kane, K Harcourt, S Mukhopadhy, Y Umrania, R Antrobus, JA Nathan, DJ Adams, A Bateman, JS Choudhary, PA Lyons, AM Condliffe, ER Chilvers, G Dougan, KG Smith
    J. Exp. Med, 2017-03-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization
    Authors: Y Chen, W Liu, Y Wang, L Zhang, J Wei, X Zhang, F He, L Zhang
    Cell. Signal, 2017-02-14;33(0):107-121.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1
    Authors: JE Hammonds, N Beeman, L Ding, S Takushi, AC Francis, JJ Wang, GB Melikyan, P Spearman
    PLoS Pathog, 2017-01-27;13(1):e1006181.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Mycobacterium tuberculosis ESAT6 and CPF10 Induce Adenosine Deaminase 2 mRNA Expression in Monocyte-Derived Macrophages
    Authors: MJ Bae, S Ryu, HJ Kim, SI Cha, CH Kim, J Lee
    Tuberc Respir Dis (Seoul), 2016-12-30;80(1):77-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Nkx2-5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E-Deficient Mice
    J Am Heart Assoc, 2016-12-19;5(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia
    Authors: Jiang Zheng
    Behav. Brain Res., 2016-11-22;319(0):188-199.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  122. oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages
    PLoS ONE, 2016-11-21;11(11):e0166798.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Fc engineering approaches to enhance the agonism and effector functions of an anti-OX40 antibody
    Authors: Mark L Chiu
    J. Biol. Chem., 2016-11-17;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage
    Genes Immun., 2016-11-17;17(7):419-425.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis
    Authors: J P T M van Leeuwe
    Bone, 2016-11-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation
    PLoS ONE, 2016-11-03;11(11):e0165909.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease
    Sci Rep, 2016-10-14;6(0):35282.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
    Nat Immunol, 2016-09-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways
    Mol Med Rep, 2016-08-25;14(4):3620-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. MicroRNAs: Potential Biomarkers and Therapeutic Targets for Alveolar Bone Loss in Periodontal Disease
    Int J Mol Sci, 2016-08-11;17(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Identification of Nedd9 as a TGF-?-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis
    Authors: Yasunori Omata
    PLoS ONE, 2016-06-23;11(6):e0157992.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection
    J Immunol, 2016-04-22;196(11):4641-9.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  133. Plasmacytoid dendritic cells and myeloid cells differently contribute to BAFF over-expression during primary HIV infection.
    Authors: Borhis G, Burelout C, Chaoul N, Smith N, Goujard C, Meyer L, Paul S, Saoudin H, Hosmalin A, Gilbert C, Herbeuval J, Richard Y
    AIDS, 2016-01-28;30(0):365-376.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.
    Authors: Tufariello J, Chapman J, Kerantzas C, Wong K, Vilcheze C, Jones C, Cole L, Tinaztepe E, Thompson V, Fenyo D, Niederweis M, Ueberheide B, Philips J, Jacobs W
    Proc Natl Acad Sci U S A, 2016-01-04;113(3):E348-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Interferon-gamma Inhibits Ebola Virus Infection.
    Authors: Rhein B, Powers L, Rogers K, Anantpadma M, Singh B, Sakurai Y, Bair T, Miller-Hunt C, Sinn P, Davey R, Monick M, Maury W
    PLoS Pathog, 2015-11-12;11(11):e1005263.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1beta, IFN-beta, and IL-15 Pathways.
    Authors: Mattiola I, Pesant M, Tentorio P, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D
    J Immunol, 2015-08-14;195(6):2818-28.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. CXCL8 and CCL20 Enhance Osteoclastogenesis via Modulation of Cytokine Production by Human Primary Osteoblasts.
    Authors: Pathak J, Bakker A, Verschueren P, Lems W, Luyten F, Klein-Nulend J, Bravenboer N
    PLoS ONE, 2015-06-23;10(6):e0131041.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.
    Authors: Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke A
    J Immunol, 2015-06-22;195(3):1092-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  139. In Vitro Spermatogenesis in Explanted Adult Mouse Testis Tissues.
    Authors: Sato T, Katagiri K, Kojima K, Komeya M, Yao M, Ogawa T
    PLoS ONE, 2015-06-12;10(6):e0130171.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  140. Genomewide Comprehensive Analysis Reveals Critical Cooperation Between Smad and c-Fos in RANKL-Induced Osteoclastogenesis.
    Authors: Omata Y, Yasui T, Hirose J, Izawa N, Imai Y, Matsumoto T, Masuda H, Tokuyama N, Nakamura S, Tsutsumi S, Yasuda H, Okamoto K, Takayanagi H, Hikita A, Imamura T, Matsuo K, Saito T, Kadono Y, Aburatani H, Tanaka S
    J Bone Miner Res, 2015-05-01;30(5):869-77.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation.
    Authors: Mediero A, Ramkhelawon B, Perez-Aso M, Moore K, Cronstein B
    J Bone Miner Res, 2015-05-01;30(5):837-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Disulfiram attenuates osteoclast differentiation in vitro: a potential antiresorptive agent.
    Authors: Ying H, Qin A, Cheng T, Pavlos N, Rea S, Dai K, Zheng M
    PLoS ONE, 2015-04-30;10(4):e0125696.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. The effect of vascular endothelial growth factor on osteoclastogenesis in rheumatoid arthritis.
    Authors: Kim H, Kim K, Kim B, Cho M, Lee S
    PLoS ONE, 2015-04-20;10(4):e0124909.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Arachidonic acid and docosahexaenoic acid suppress osteoclast formation and activity in human CD14+ monocytes, in vitro.
    Authors: Kasonga A, Deepak V, Kruger M, Coetzee M
    PLoS ONE, 2015-04-13;10(4):e0125145.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Glycogen synthase kinase 3beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production.
    Authors: Ko R, Park J, Ha H, Choi Y, Lee S
    Nat Commun, 2015-04-01;6(0):6765.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Xanthine oxidoreductase regulates macrophage IL1beta secretion upon NLRP3 inflammasome activation.
    Authors: Ives A, Nomura J, Martinon F, Roger T, LeRoy D, Miner J, Simon G, Busso N, So A
    Nat Commun, 2015-03-24;6(0):6555.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.
    Authors: van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S
    PLoS Pathog, 2015-03-24;11(3):e1004671.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-gamma-treated macrophages to Pseudomonas aeruginosa infection.
    Authors: Singh S, Barr H, Liu Y, Robins A, Heeb S, Williams P, Fogarty A, Camara M, Martinez-Pomares L
    PLoS ONE, 2015-02-23;10(2):e0117447.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. The effect of hyperglycaemia on in vitro cytokine production and macrophage infection with Mycobacterium tuberculosis.
    Authors: Lachmandas E, Vrieling F, Wilson L, Joosten S, Netea M, Ottenhoff T, van Crevel R
    PLoS ONE, 2015-02-09;10(2):e0117941.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy.
    Authors: Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen D, Zhou J, Xiao G
    J Biol Chem, 2015-02-03;290(13):8081-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  151. High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus.
    Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M
    J Virol, 2015-01-21;89(7):3859-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Transcriptome analysis of Kaposi's sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells.
    Authors: Purushothaman P, Thakker S, Verma S
    J Virol, 2014-12-31;89(6):3093-111.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  153. Human osteoclasts are inducible immunosuppressive cells in response to T cell-derived IFN-gamma and CD40 ligand in vitro.
    Authors: Li H, Lu Y, Qian J, Zheng Y, Zhang M, Bi E, He J, Liu Z, Xu J, Gao J, Yi Q
    J Bone Miner Res, 2014-12-01;29(12):2666-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes.
    Authors: Gallagher K, Joshi A, Carson W, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman E, Henke P, Hogaboam C, Burant C, Kunkel S
    Diabetes, 2014-11-03;64(4):1420-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  155. A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.
    Authors: Hedl M, Abraham C
    Proc Natl Acad Sci U S A, 2014-09-02;111(37):13451-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.
    Authors: Tang, Songqing, Chen, Taoyong, Yu, Zhou, Zhu, Xuhui, Yang, Mingjin, Xie, Bin, Li, Nan, Cao, Xuetao, Wang, Jianli
    Nat Commun, 2014-08-14;5(0):4657.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  157. In vivo detection of macrophage recruitment in hind-limb ischemia using a targeted near-infrared fluorophore.
    Authors: Yoo, Jung Sun, Das, Raj Kuma, Jow, Zhi Yen, Chang, Young-Ta
    PLoS ONE, 2014-07-29;9(7):e103721.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Laser ablation-inductively coupled plasma mass spectrometry: an emerging technology for detecting rare cells in tissue sections.
    Authors: Managh A, Hutchinson R, Riquelme P, Broichhausen C, Wege A, Ritter U, Ahrens N, Koehl G, Walter L, Florian C, Schlitt H, Reid H, Geissler E, Sharp B, Hutchinson J
    J Immunol, 2014-07-23;193(5):2600-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.
    Authors: Deng B, Wang C, Arnardottir H, Li Y, Cheng C, Dalli J, Serhan C
    PLoS ONE, 2014-07-18;9(7):e102362.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils.
    Authors: Eltboli O, Bafadhel M, Hollins F, Wright A, Hargadon B, Kulkarni N, Brightling C
    BMC Pulm Med, 2014-07-09;14(0):112.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  161. Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells.
    Authors: Giese, Sebastia, Marsh, Mark
    PLoS Pathog, 2014-07-03;10(7):e1004189.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis.
    Authors: Osorio E, Travi B, da Cruz A, Saldarriaga O, Medina A, Melby P
    PLoS Pathog, 2014-06-26;10(6):e1004165.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  163. A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
    Authors: Lewis, Nuruddee, Patnaude, Lori A, Pelletier, Josephin, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan, Stefanopoulos, Dimitria, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christia, Hickey, Eugene R, Modis, Louise K
    PLoS ONE, 2014-06-26;9(6):e100883.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
    Authors: Kemp J, Medina-Gomez C, Estrada K, St Pourcain B, Heppe D, Warrington N, Oei L, Ring S, Kruithof C, Timpson N, Wolber L, Reppe S, Gautvik K, Grundberg E, Ge B, van der Eerden B, van de Peppel J, Hibbs M, Ackert-Bicknell C, Choi K, Koller D, Econs M, Williams F, Foroud T, Zillikens M, Ohlsson C, Hofman A, Uitterlinden A, Davey Smith G, Jaddoe V, Tobias J, Rivadeneira F, Evans D
    PLoS Genet, 2014-06-19;10(6):e1004423.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  165. Comparative analysis of the capacity of elite suppressor CD4+ and CD8+ T cells to inhibit HIV-1 replication in monocyte-derived macrophages.
    Authors: Walker-Sperling V, Buckheit R, Blankson J
    J Virol, 2014-06-18;88(17):9789-98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  166. The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.
    Authors: Hedl M, Zheng S, Abraham C
    J Immunol, 2014-05-19;192(12):5924-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  167. TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in human non-small cell lung cancer.
    Authors: Yuan, Zhihong, Mehta, Hiren J, Mohammed, Kamal, Nasreen, Najmunis, Roman, Robert, Brantly, Mark, Sadikot, Ruxana T
    PLoS ONE, 2014-05-19;9(5):e94241.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  168. miR-27a regulates inflammatory response of macrophages by targeting IL-10.
    Authors: Xie N, Cui H, Banerjee S, Tan Z, Salomao R, Fu M, Abraham E, Thannickal V, Liu G
    J Immunol, 2014-05-16;193(1):327-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  169. GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer.
    Authors: Nebiker C, Han J, Eppenberger-Castori S, Iezzi G, Hirt C, Amicarella F, Cremonesi E, Huber X, Padovan E, Angrisani B, Droeser R, Rosso R, Bolli M, Oertli D, von Holzen U, Adamina M, Muraro M, Mengus C, Zajac P, Sconocchia G, Zuber M, Tornillo L, Terracciano L, Spagnoli G
    Clin Cancer Res, 2014-04-15;20(12):3094-106.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  170. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.
    Authors: Noubade, Rajkumar, Wong, Kit, Ota, Naruhisa, Rutz, Sascha, Eidenschenk, Celine, Valdez, Patricia, Ding, Jiabing, Peng, Ivan, Sebrell, Andrew, Caplazi, Patrick, DeVoss, Jason, Soriano, Robert H, Sai, Tao, Lu, Rongze, Modrusan, Zora, Hackney, Jason, Ouyang, Wenjun
    Nature, 2014-04-13;509(7499):235-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Monocyte to macrophage differentiation goes along with modulation of the plasmalogen pattern through transcriptional regulation.
    Authors: Wallner S, Grandl M, Konovalova T, Sigruner A, Kopf T, Peer M, Orso E, Liebisch G, Schmitz G
    PLoS ONE, 2014-04-08;9(4):e94102.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival.
    Authors: Yuan Z, Syed M, Panchal D, Joo M, Colonna M, Brantly M, Sadikot R
    J Biol Chem, 2014-04-07;289(21):15118-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Epstein-Barr virus infection induces indoleamine 2,3-dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-kappaB pathways: impairment in T cell functions.
    Authors: Liu W, Lin Y, Xiao H, Xing S, Chen H, Chi P, Zhang G
    J Virol, 2014-04-02;88(12):6660-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  174. Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-gamma.
    Authors: Pahl J, Kwappenberg K, Varypataki E, Santos S, Kuijjer M, Mohamed S, Wijnen J, van Tol M, Cleton-Jansen A, Egeler R, Jiskoot W, Lankester A, Schilham M
    J Exp Clin Cancer Res, 2014-03-10;33(0):27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  175. Ocaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia.
    Authors: Cheney C, Stephens D, Mo X, Rafiq S, Butchar J, Flynn J, Jones J, Maddocks K, O'Reilly A, Ramachandran A, Tridandapani S, Muthusamy N, Byrd J
    MAbs, 2014-03-04;6(3):749-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  176. MiR-503 regulates osteoclastogenesis via targeting RANK.
    Authors: Chen C, Cheng P, Xie H, Zhou H, Wu X, Liao E, Luo X
    J Bone Miner Res, 2014-02-01;29(2):338-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  177. The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.
    Authors: van Wilgenburg, Bonnie, Moore, Michael, James, William, Cowley, Sally A
    PLoS ONE, 2014-01-22;9(1):e86071.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  178. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.
    Authors: Beckwith K, Frissora F, Stefanovski M, Towns W, Cheney C, Mo X, Deckert J, Croce C, Flynn J, Andritsos L, Jones J, Maddocks K, Lozanski G, Byrd J, Muthusamy N
    Leukemia, 2014-01-21;28(7):1501-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.
    Authors: Garcia S, Krausz S, Ambarus C, Fernandez B, Hartkamp L, van Es I, Hamann J, Baeten D, Tak P, Reedquist K
    PLoS ONE, 2014-01-03;9(1):e82088.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  180. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.
    Authors: Hamada, Michito, Nakamura, Megumi, Tran, Mai Thi, Moriguchi, Takashi, Hong, Cynthia, Ohsumi, Takayuki, Dinh, Tra Thi, Kusakabe, Manabu, Hattori, Motochik, Katsumata, Tokio, Arai, Satoko, Nakashima, Katsuhik, Kudo, Takashi, Kuroda, Etsushi, Wu, Chien-Hu, Kao, Pei-Han, Sakai, Masaharu, Shimano, Hitoshi, Miyazaki, Toru, Tontonoz, Peter, Takahashi, Satoru
    Nat Commun, 2014-01-01;5(0):3147.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
    Authors: Kauder, Steven E, Santell, Lydia, Mai, Elaine, Wright, Lilyan Y, Luis, Elizabet, N'Diaye, Elsa N, Lutman, Jeff, Ratti, Navneet, Sa, Susan M, Maun, Henry R, Stefanich, Eric, Gonzalez, Lino C, Graham, Robert R, Diehl, Lauri, Faubion, William, Keir, Mary E, Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A, Egen, Jackson
    PLoS ONE, 2013-12-23;8(12):e83958.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  182. Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions.
    Authors: Nomura T, Aoyama M, Waguri-Nagaya Y, Goto Y, Suzuki M, Miyazawa K, Asai K, Goto S
    Exp Cell Res, 2013-12-17;321(2):167-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Differential responses of disease-resistant and disease-susceptible primate macrophages and myeloid dendritic cells to simian hemorrhagic fever virus infection.
    Authors: Vatter H, Brinton M
    J Virol, 2013-12-11;88(4):2095-106.
    Species: Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio anubis (Olive Baboon)
    Sample Types: Whole Cells
    Applications: Bioassay
  184. STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus.
    Authors: Spurrell, Emma, Gangeswaran, Rathi, Wang, Pengju, Cao, Fengyu, Gao, Dongling, Feng, Baisui, Wold, William, Tollefson, Ann, Lemoine, Nicholas, Wang, Yaohe
    J Virol, 2013-12-11;88(4):2291-300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Bone marrow stromal cells derived MCP-1 reverses the inhibitory effects of multiple myeloma cells on osteoclastogenesis by upregulating the RANK expression.
    Authors: Liu Z, Xu J, Li H, Zheng Y, He J, Liu H, Zhong Y, Lu Y, Hong B, Zhang M, Lin P, Du J, Hou J, Qian J, Kwak L, Yi Q, Yang J
    PLoS ONE, 2013-12-10;8(12):e82453.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  186. Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2.
    Authors: Engstrom A, Erlandsson A, Delbro D, Wijkander J
    Int J Oncol, 2013-12-02;44(2):385-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages.
    Authors: Haselow K, Bode J, Wammers M, Ehlting C, Keitel V, Kleinebrecht L, Schupp A, Haussinger D, Graf D
    J Leukoc Biol, 2013-08-29;94(6):1253-64.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
    Authors: He W, Mazumder A, Wilder T, Cronstein B
    FASEB J, 2013-05-16;27(9):3446-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis.
    Authors: Logan J, Sophocleous A, Marino S, Muir M, Brunton V, Idris A
    J Bone Miner Res, 2013-05-01;28(5):1229-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  190. TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.
    Authors: Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume M, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T, Hibi T
    Immunology, 2013-05-01;139(1):19-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue.
    Authors: Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensebe L
    FASEB J, 2013-04-16;27(8):2977-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  192. A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo.
    Authors: Veitonmaki N, Hansson M, Zhan F, Sundberg A, Lofstedt T, Ljungars A, Li Z, Martinsson-Niskanen T, Zeng M, Yang Y, Danielsson L, Kovacek M, Lundqvist A, Martensson L, Teige I, Tricot G, Frendeus B
    Cancer Cell, 2013-04-15;23(4):502-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  193. HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors.
    Authors: van der Kraan A, Chai R, Singh P, Lang B, Xu J, Gillespie M, Price J, Quinn J
    Biochem J, 2013-04-15;451(2):235-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  194. Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.
    Authors: Choi H, Kang H, Jung E, Kim T, Lin J, Lee S
    Cell Res, 2013-03-12;23(4):524-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  195. Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
    Authors: Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J
    Hum Mol Genet, 2013-01-31;22(9):1807-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  196. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
    Authors: Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, Tsai I, Li L, Hsieh S
    Blood, 2012-11-14;121(1):95-106.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Macrophages induce differentiation of plasma cells through CXCL10/IP-10.
    J. Exp. Med., 2012-09-17;209(10):1813-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  198. Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
    Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
    J. Immunol., 2011-06-10;187(2):748-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  199. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes.
    Authors: Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T
    J. Immunol., 2011-05-06;186(12):6925-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  200. Glucocorticoids maintain human osteoclasts in the active mode of their resorption cycle.
    Authors: Soe K, Delaisse JM
    J. Bone Miner. Res., 2010-10-01;25(10):2184-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  201. Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4.
    Authors: Knowles HJ, Cleton-Jansen AM, Korsching E, Athanasou NA
    FASEB J., 2010-07-28;24(12):4648-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  202. IL-3 inhibits human osteoclastogenesis and bone resorption through downregulation of c-Fms and diverts the cells to dendritic cell lineage.
    Authors: Gupta N, Barhanpurkar AP, Tomar GB
    J. Immunol., 2010-07-19;185(4):2261-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  203. A multiplex immunoassay for human adipokine profiling.
    Authors: Schipper HS, De Jager W, van Dijk ME, Meerding J, Zelissen PM, Adan RA, Prakken BJ, Kalkhoven E
    Clin. Chem., 2010-06-08;56(0):1320.
    Applications: ELISA (Standard)
  204. Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
    Authors: Lamprecht B, Walter K, Kreher S, Kumar R, Hummel M, Lenze D, Kochert K, Bouhlel MA, Richter J, Soler E, Stadhouders R, Johrens K, Wurster KD, Callen DF, Harte MF, Giefing M, Barlow R, Stein H, Anagnostopoulos I, Janz M, Cockerill PN, Siebert R, Dorken B, Bonifer C, Mathas S
    Nat. Med., 2010-05-02;16(5):571-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
    Authors: Tso GH, Law HK, Tu W
    Stem Cells, 2010-05-01;28(5):939-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  206. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
    Authors: Mengshol JA, Golden-Mason L, Arikawa T
    PLoS ONE, 2010-03-04;5(3):e9504.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  207. Characterisation of the osteoclastogenic potential of human osteoblastic and fibroblastic conditioned media.
    Authors: Costa-Rodrigues J, Teixeira CA, Sampaio P, Fernandes MH
    J. Cell. Biochem., 2010-01-01;109(1):205-16.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  208. Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients.
    Authors: Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, Cantatore FP, Tamma R, Rizzi R, Liso V, Zallone A, Grano M
    Leukemia, 2009-07-09;23(11):2139-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  209. The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering.
    Authors: Pytlik R, Stehlik D, Soukup T, Kalbacova M, Rypacek F, Trc T, Mulinkova K, Michnova P, Kideryova L, Zivny J, Klener P, Vesela R, Trneny M, Klener P
    Biomaterials, 2009-04-10;30(20):3415-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  210. Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.
    Authors: Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K
    J. Biol. Chem., 2009-03-19;284(21):14637-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  211. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
    Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
    Bone, 2009-03-02;44(6):1143-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  212. Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts.
    Authors: Mizutani K, Sud S, Pienta KJ
    J. Cell. Biochem., 2009-03-01;106(4):563-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  213. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
    Authors: Mabilleau G, Sabokbar A
    PLoS ONE, 2009-01-12;4(1):e4173.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  214. Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis.
    Authors: Chen H, Campbell RA, Chang Y, Li M, Wang CS, Li J, Sanchez E, Share M, Steinberg J, Berenson A, Shalitin D, Zeng Z, Gui D, Perez-Pinera P, Berenson RJ, Said J, Bonavida B, Deuel TF, Berenson JR
    Blood, 2008-12-05;113(9):1992-2002.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  215. Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
    Authors: Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J
    Arthritis Rheum., 2008-12-01;58(12):3820-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  216. Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway.
    Authors: Chamoux E, Houde N, L'Eriger K, Roux S
    J. Cell. Physiol., 2008-08-01;216(2):536-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  217. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.
    Authors: Savage ND, De Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH
    J. Immunol., 2008-08-01;181(3):2220-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  218. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma.
    Authors: Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Mitsiades C, Chauhan D, Okawa Y, Munshi NC, Richardson PG, Anderson KC
    Leukemia, 2008-07-03;22(10):1925-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  219. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
    Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
    Exp. Hematol., 2008-05-27;36(8):1035-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  220. Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions.
    Authors: Boissy P, Andersen TL, Lund T, Kupisiewicz K, Plesner T, Delaisse JM
    Leuk. Res., 2008-04-18;32(11):1661-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  221. p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
    Authors: Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, Shen Z, Raje N, Kiziltepe T, Ocio EM, Chauhan D, Tassone P, Munshi N, Campbell RM, Dios AD, Shih C, Starling JJ, Tamura K, Anderson KC
    Br. J. Haematol., 2008-04-07;141(5):598-606.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  222. Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis.
    Authors: Clerin V, Shih HH, Deng N, Hebert G, Resmini C, Shields KM, Feldman JL, Winkler A, Albert L, Maganti V, Wong A, Paulsen JE, Keith JC, Vlasuk GP, Pittman DD
    Atherosclerosis, 2008-02-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  223. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes.
    Authors: Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R
    J. Leukoc. Biol., 2008-02-15;83(5):1181-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  224. Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
    Authors: Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Chauhan D, Munshi NC, Richardson PG, Anderson KC
    Br. J. Haematol., 2007-10-01;139(1):55-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  225. Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis.
    Authors: Colucci S, Brunetti G, Cantatore FP, Oranger A, Mori G, Quarta L, Cirulli N, Mancini L, Corrado A, Grassi FR, Grano M
    J. Pathol., 2007-05-01;212(1):47-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  226. Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice.
    Authors: Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL, Fu WM
    J. Biol. Chem., 2006-11-10;282(4):2346-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  227. Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts.
    Authors: de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V
    J. Cell. Biochem., 2006-05-15;98(2):370-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  228. LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis.
    Authors: Edwards JR, Sun SG, Locklin R, Shipman CM, Adamopoulos IE, Athanasou NA, Sabokbar A
    Arthritis Rheum., 2006-05-01;54(5):1451-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  229. Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes.
    Authors: Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC
    J. Immunol. Methods, 2005-11-21;308(1):138-55.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Whole Cells
    Applications: Bioassay
  230. Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis.
    Authors: Roux S, Lambert-Comeau P, Saint-Pierre C, Lepine M, Sawan B, Parent JL
    Biochem. Biophys. Res. Commun., 2005-07-22;333(1):42-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  231. IL-1 mediates TNF-induced osteoclastogenesis.
    Authors: Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL
    J. Clin. Invest., 2005-02-01;115(2):282-90.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  232. IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis.
    Authors: Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB
    J. Immunol., 2004-05-15;172(10):6476-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  233. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16.
    Authors: Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW
    J. Immunol., 2004-03-15;172(6):3678-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  234. Reprogramming of IL-10 activity and signaling by IFN-gamma.
    Authors: Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB
    J. Immunol., 2003-11-15;171(10):5034-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. How long will recombinant human M-CSF last in cell culture?

    • End-users will need to determine the appropriate concentration and timing when adding Recombinant Human M-CSF Proteins to cell culture experiments. The addition of protein may be dependent on certain culture conditions, including the cell number, density, and media content. For techniques and methodologies, we recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

  2. Does recombinant human M-CSF show activity in mouse cells?

    • We evaluate the bioactivity of Recombinant Human M-CSF Protein (Catalog # 216-MC) in a cell proliferation assay using mouse myelogenous leukemia lymphoblast cells. Catalog # 216-MC exhibits an ED50 in the range of 0.5-1.5 ng/mL in this assay using mouse cells. We also offer the Recombinant Mouse M-CSF Protein (Catalog # 416-ML) for use in mouse assay systems.

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Reviews for Recombinant Human M-CSF Protein

Average Rating: 4.9 (Based on 15 Reviews)

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Recombinant Human M-CSF Protein
By Anonymous on 05/01/2022
Application: CellProlif

This product should be kept in -80 freezer

Cell Proliferation Recombinant Human M-CSF Protein 216-MC
Recombinant Human M-CSF Protein
By Anonymous on 01/24/2021
Application: In vitro bioactivity in cell culture
In vitro bioactivity in cell culture Recombinant Human M-CSF Protein 216-MC
Recombinant Human M-CSF Protein
By Anonymous on 01/18/2021
Application: In vitro bioactivity in cell culture
Reason for Rating: 25ng/ml MCSF, 50ng/ml RANKL works well for human osteoclast differentiation assay.
In vitro bioactivity in cell culture Recombinant Human M-CSF Protein 216-MC
Recombinant Human M-CSF Protein
By Anonymous on 12/29/2020
Application: Stem/Immune cell maintenance or differentiation
Recombinant Human M-CSF Protein
By Anonymous on 12/18/2020
Application: Binding assay/Protein-protein interaction
Binding assay/Protein-protein interaction Recombinant Human M-CSF Protein 216-MC
Recombinant Human M-CSF Protein
By Anonymous on 11/20/2020
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: Used at 25 ng/ml to plate human PBMCs for subsequent macrophage culture. Consistently produced good macrophages.
Recombinant Human M-CSF Protein
By Supriya Sen on 10/05/2020
Application: Stem/Immune cell maintenance or differentiation
Recombinant Human M-CSF Protein
By Anonymous on 01/10/2020
Application: CellProlif
Recombinant Human M-CSF Protein
By Vaishali Sarode on 02/15/2019
Application: INHIBITION
Recombinant Human M-CSF Protein
By Anonymous on 11/18/2017
Application: Cell Differentiation

Monocyte to Macrophage differentiation

Other Recombinant Human M-CSF Protein 216-MC
Recombinant Human M-CSF Protein
By Abby Sukarto on 05/03/2017
Recombinant Human M-CSF Protein
By Anonymous on 12/15/2016
Application: Stem/Immune cell maintenance or differentiation

We use for blood cell differentiation.

Recombinant Human M-CSF Protein
By preety panwar on 05/18/2016
Application: CellProlif
Cell Proliferation Recombinant Human M-CSF Protein 216-MC
Recombinant Human M-CSF Protein
By Sohini Roy on 05/12/2016
Application: Differentiating primary human monocytes to macrophages in vitro and use the macrophages for further functional assays
Reason for Rating: Works very well for differentiation of primary human monocytes to macrophages.
Recombinant Human M-CSF Protein
By SOjan Abraham on 01/21/2016
Application: In vitro bioactivity in cell culture