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Recombinant Human NT-3 Protein

Catalog #: 267-N3
71 Citations Datasheet / COA / SDS
Newer Version Available: 11346-N3
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Carrier Free

Catalog # Availability Size / Price Qty
267-N3-005/CF
267-N3-025/CF

With Carrier

Catalog # Availability Size / Price Qty
267-N3-005
267-N3-025
Recombinant Human NT-3 Protein SDS-PAGE
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Product Details
Citations (71)
FAQs
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human NT-3 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using BaF mouse pro-B cells transfected with TrkB. The ED50 for this effect is 4.00-40.0 ng/mL.

Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human NT-3 protein
Tyr139-Thr257 (K196R)
Accession #
P20783
N-terminal Sequence
Analysis
Tyr139
Predicted Molecular Mass
13.7 kDa

Product Datasheets

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267-N3 (with carrier)

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SDS

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267-N3/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

267-N3

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

267-N3/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute 5 µg vials at 50 µg/mL in sterile PBS. Reconstitute 25 µg or larger vials at 100 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

SDS-PAGE Recombinant Human NT-3 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human NT-3 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

Bioactivity View Larger

Recombinant Human NT-3 (Catalog # 267-N3) stimulates cell proliferation in the BaF mouse pro-B cell line transfected with TrkB. The ED50 for this effect is 4.00-40.0 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: NT-3

Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive NT-3 is predicted to be a non-covalently linked homodimer.

The NT-3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT-3. The amino acid sequence of mature NT-3 is identical in human, mouse and rat. NT-3 transcripts have been detected in the cerebellum, hippocampus, placenta, heart, skin, and skeletal muscle. NT-3 primarily activates the TrkC tyrosine kinase receptor. In addition, NT-3 can activate Trk and TrkB kinase receptors in certain cell systems. NT-3 can also bind with low affinity to the low affinity NGF receptor.

References
  1. Eide, F.F. et al. (1993) Exp. Neurol. 121:200.
  2. Snider, W.D. (1994) Cell 77:627.
  3. Barbacid, M. (1994) J. Neurobiol. 25:1386.
Long Name
Neurotrophin 3
Entrez Gene IDs
4908 (Human)
Alternate Names
HDNF; MGC129711; Nerve growth factor 2; Neurotrophic factor; neurotrophin 3; neurotrophin-3; NGF2; NGF-2; NT3; NT-3; NTF3

Citations for Recombinant Human NT-3 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

71 Citations: Showing 1 - 10
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  1. Neural and metabolic dysregulation in PMM2-deficient human in vitro neural models
    Authors: Radenkovic, S;Budhraja, R;Klein-Gunnewiek, T;King, AT;Bhatia, TN;Ligezka, AN;Driesen, K;Shah, R;Ghesquière, B;Pandey, A;Kasri, NN;Sloan, SA;Morava, E;Kozicz, T;
    Cell reports
    Species: Human hepegivirus
    Sample Types: Whole Cells
    Applications: Bioassay
  2. A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity
    Authors: Clayton, BLL;Kristell, JD;Allan, KC;Cohn, EF;Karl, M;Jerome, AD;Garrison, E;Maeno-Hikichi, Y;Sturno, AM;Kerr, A;Shick, HE;Sepeda, JA;Freundt, EC;Sas, AR;Segal, BM;Miller, RH;Tesar, PJ;
    Nature neuroscience
    Species: Human hepegivirus
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy
    Authors: Pedrosa, L;Bedia, C;Diao, D;Mosteiro, A;Ferr�s, A;Stanzani, E;Mart�nez-Soler, F;Tortosa, A;Pineda, E;Aldecoa, I;Centellas, M;Mu�oz-Tudur�, M;Sevilla, A;Sierra, �;Gonz�lez S�nchez, JJ;
    Cells
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  4. Pervasive environmental chemicals impair oligodendrocyte development
    Authors: EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar
    bioRxiv : the preprint server for biology, 2023-02-12;0(0):.
    Species: Human, Mouse
    Sample Types: Organoid, Whole Cells
    Applications: Bioassay
  5. Stem cell-nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy
    Authors: YH Lai, CY Su, HW Cheng, CY Chu, LB Jeng, CS Chiang, WC Shyu, SY Chen
    Nature Communications, 2023-01-18;14(1):285.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
    Authors: Y Tang, DJ Kwiatkowsk, EP Henske
    Nature Communications, 2022-08-26;13(1):5018.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay
    Authors: S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller
    Nature Communications, 2022-08-25;13(1):5003.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation
    Authors: M Sawamura, K Imamura, R Hikawa, T Enami, A Nagahashi, H Yamakado, H Ichijo, T Fujisawa, H Yamashita, S Minamiyama, M Kaido, H Wada, M Urushitani, H Inoue, N Egawa, R Takahashi
    Scientific Reports, 2022-07-25;12(1):12636.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1
    Authors: MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano
    PLoS ONE, 2022-07-01;17(7):e0269683.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Physical and functional interactome atlas of human receptor tyrosine kinases.
    Authors: Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M
    EMBO Rep, 2022-04-05;23(6):e54041.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  11. Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases
    Authors: JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al
    Frontiers in Pharmacology, 2022-03-18;13(0):862085.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice
    Authors: D Segelcke, HK Fischer, M Hütte, S Dennerlein, F Benseler, N Brose, EM Pogatzki-Z, M Schmidt
    Cell Reports, 2021-12-21;37(12):110152.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Reprogramming Human Adult Fibroblasts into GABAergic Interneurons
    Authors: A Bruzelius, S Kidnapilla, J Drouin-Oue, T Stoker, RA Barker, D Rylander O
    Cells, 2021-12-08;10(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits
    Authors: P Göttle, K Schichel, L Reiche, L Werner, A Zink, A Prigione, P Küry
    Frontiers in Cellular Neuroscience, 2021-11-23;15(0):777542.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Phoenix auditory neurons as 3R cell model for high throughput screening of neurogenic compounds
    Authors: F Rousset, D Schmidbaue, S Fink, Y Adel, B Obexer, M Müller, R Glueckert, H Löwenheim, P Senn
    Hearing research, 2021-11-14;414(0):108391.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  16. A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin
    Authors: P Chennampal, A Sayed-Zahi, P Soundarara, J Sharp, GA Cox, SD Collins, RL Smith
    Scientific Reports, 2021-09-13;11(1):18168.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating &beta?amyloid metabolism?associated enzymes
    Authors: H Jiang, F Niu, Y Zheng, Y Xu
    Molecular Medicine Reports, 2021-02-19;23(4):1-12.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: CAR-T
  18. A quantitative model of cellular decision making in direct neuronal reprogramming
    Authors: A Merlevede, EM Legault, V Drugge, RA Barker, J Drouin-Oue, V Olariu
    Scientific Reports, 2021-01-15;11(1):1514.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay
    Authors: T Kurosaki, N Imamachi, C Pröschel, S Mitsutomi, R Nagao, N Akimitsu, LE Maquat
    Nature Cell Biology, 2021-01-08;23(1):40-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons
    Authors: J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O
    Cells, 2020-11-10;9(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
    Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
    Cell Stem Cell, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons
    Authors: S Nolbrant, J Giacomoni, DB Hoban, A Bruzelius, M Birtele, D Chandler-M, M Pereira, DR Ottosson, SA Goldman, M Parmar
    Stem Cell Reports, 2020-09-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro
    Authors: KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri
    Cells, 2020-08-21;9(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  24. Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants
    Authors: C Frick, S Fink, D Schmidbaue, F Rousset, H Eickhoff, A Tropitzsch, B Kramer, P Senn, R Glueckert, H Rask-Ander, KH Wiesmüller, H Löwenheim, M Müller
    Brain Sci, 2020-08-21;10(9):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction
    Authors: N Michel, P Narayanan, O Shomroni, M Schmidt
    Cell Rep, 2020-07-21;32(3):107912.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Variation of Human Neural Stem Cells Generating Organizer States In�Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
    Authors: N Micali, SK Kim, M Diaz-Busta, G Stein-O'Br, S Seo, JH Shin, BG Rash, S Ma, Y Wang, NA Olivares, JI Arellano, KR Maynard, EJ Fertig, AJ Cross, RW Bürli, NJ Brandon, DR Weinberger, JG Chenoweth, DJ Hoeppner, N Sestan, P Rakic, C Colantuoni, RD McKay
    Cell Rep, 2020-05-05;31(5):107599.
    Species: Mouse
    Sample Types:
    Applications: Cell Culture
  27. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
    Authors: EE Burke, JG Chenoweth, JH Shin, L Collado-To, SK Kim, N Micali, Y Wang, C Colantuoni, RE Straub, DJ Hoeppner, HY Chen, A Sellers, K Shibbani, GR Hamersky, M Diaz Busta, BN Phan, WS Ulrich, C Valencia, A Jaishankar, AJ Price, A Rajpurohit, SA Semick, RW Bürli, JC Barrow, DJ Hiler, SC Page, K Martinowic, TM Hyde, JE Kleinman, KF Berman, JA Apud, AJ Cross, NJ Brandon, DR Weinberger, BJ Maher, RDG McKay, AE Jaffe
    Nat Commun, 2020-01-23;11(1):462.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  28. Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
    Authors: AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann
    Cell Rep, 2020-01-21;30(3):932-946.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  29. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors
    Authors: M Matjusaiti, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, A Williams, SM Pollard
    Stem Cell Reports, 2019-11-07;13(6):1053-1067.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  30. iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases
    Authors: CY Lin, M Yoshida, LT Li, A Ikenaka, S Oshima, K Nakagawa, H Sakurai, E Matsui, T Nakahata, MK Saito
    JCI Insight, 2019-09-19;4(18):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. A cell fitness selection model for neuronal survival during development
    Authors: Y Wang, H Wu, P Fontanet, S Codeluppi, N Akkuratova, C Petitpré, Y Xue-Franzé, K Niederreit, A Sharma, F Da Silva, G Comai, G Agirman, D Palumberi, S Linnarsson, I Adameyko, A Moqrich, A Schedl, G La Manno, S Hadjab, F Lallemend
    Nat Commun, 2019-09-12;10(1):4137.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Cell Culture
  32. Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
    Authors: Z Liu, M Osipovitch, A Benraiss, NPT Huynh, R Foti, J Bates, D Chandler-M, RL Findling, PJ Tesar, M Nedergaard, MS Windrem, SA Goldman
    Cell Rep, 2019-06-25;27(13):3832-3843.e6.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  33. pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis
    Authors: D Kremer, J Gruchot, V Weyers, L Oldemeier, P Göttle, L Healy, J Ho Jang, Y Kang T Xu, C Volsko, R Dutta, BD Trapp, H Perron, HP Hartung, P Küry
    Proc. Natl. Acad. Sci. U.S.A., 2019-06-18;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats
    Authors: J Zhang, L Wang, H Cao, N Chen, B Yan, X Ao, H Zhao, J Chu, M Huang, Z Zhang
    J. Cell. Mol. Med., 2019-01-22;0(0):.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  35. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
    Authors: Z Melamed, J López-Erau, MW Baughn, O Zhang, K Drenner, Y Sun, F Freyermuth, MA McMahon, MS Beccari, JW Artates, T Ohkubo, M Rodriguez, N Lin, D Wu, CF Bennett, F Rigo, S Da Cruz, J Ravits, C Lagier-Tou, DW Cleveland
    Nat. Neurosci., 2019-01-14;22(2):180-190.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation
    Authors: M Osipovitch, A Asenjo Mar, JN Mariani, A Cornwell, S Dhaliwal, L Zou, D Chandler-M, S Wang, X Li, SJ Benraiss, R Agate, A Lampp, A Benraiss, MS Windrem, SA Goldman
    Cell Stem Cell, 2018-12-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
    Authors: N Tsuburaya, K Homma, T Higuchi, A Balia, H Yamakoshi, N Shibata, S Nakamura, H Nakagawa, SI Ikeda, N Umezawa, N Kato, S Yokoshima, M Shibuya, M Shimonishi, H Kojima, T Okabe, T Nagano, I Naguro, K Imamura, H Inoue, T Fujisawa, H Ichijo
    Nat Commun, 2018-07-10;9(1):2668.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Teriflunomide promotes oligodendroglial differentiation and myelination
    Authors: P Göttle, A Manousi, D Kremer, L Reiche, HP Hartung, P Küry
    J Neuroinflammation, 2018-03-13;15(1):76.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Integrative proteomic and transcriptomic analysis provides evidence for TrkB (NTRK2) as a therapeutic target in combination with tyrosine kinase inhibitors for non-small cell lung cancer
    Authors: DR Gomez, LA Byers, M Nilsson, L Diao, J Wang, L Li, P Tong, M Hofstad, B Saigal, I Wistuba, N Kalhor, S Swisher, Y Fan, WK Hong, M Suraokar, C Behrens, C Moran, JV Heymach
    Oncotarget, 2018-01-30;9(18):14268-14284.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation
    Authors: EA Newman, S Chukkapall, D Bashllari, TT Thomas, RA Van Noord, ER Lawlor, MJ Hoenerhoff, AW Opipari, VP Opipari
    Cell Death Dis, 2017-12-13;8(12):3208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
    Authors: N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson
    Stem Cells Int, 2017-11-26;2017(0):5718608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
    Authors: T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji
    Cell Stem Cell, 2017-11-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
    Authors: J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar
    EMBO Mol Med, 2017-08-01;9(8):1117-1131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Comparative Analysis of the Cell Fates of Induced Schwann Cells from Subcutaneous Fat Tissue and Na�ve Schwann Cells in the Sciatic Nerve Injury Model
    Authors: M Zhang, MH Jiang, DW Kim, W Ahn, E Chung, Y Son, G Chi
    Biomed Res Int, 2017-06-20;2017(0):1252851.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Differentiation of nestin?negative human hair follicle outer root sheath cells into neurons in�vitro
    Authors: W Wu, XL Wu, YQ Ji, Z Gao
    Mol Med Rep, 2017-05-16;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
    Authors: S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase
    Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;114(12):E2486-E2493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors
    Authors: SK Goparaju, K Kohda, K Ibata, A Soma, Y Nakatake, T Akiyama, S Wakabayash, M Matsushita, M Sakota, H Kimura, M Yuzaki, SB Ko, MS Ko
    Sci Rep, 2017-02-13;7(0):42367.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
    Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
    PLoS ONE, 2017-02-13;12(2):e0171947.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Arctigenin protects against neuronal hearing loss by promoting neural stem cell survival and differentiation
    Authors: Xinghua Huang
    Genesis, 2017-02-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Small molecules increase direct neural conversion of human fibroblasts
    Sci Rep, 2016-12-05;6(0):38290.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine
    Authors: T Nakazawa, M Kikuchi, M Ishikawa, H Yamamori, K Nagayasu, T Matsumoto, M Fujimoto, Y Yasuda, M Fujiwara, S Okada, K Matsumura, A Kasai, A Hayata-Tak, N Shintani, S Numata, K Takuma, W Akamatsu, H Okano, A Nakaya, H Hashimoto, R Hashimoto
    Schizophr. Res., 2016-10-27;181(0):75-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42
    J Neurosci, 2016-05-25;36(21):5724-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Sequential Differentiation of Embryonic Stem Cells into Neural Epithelial-Like Stem Cells and Oligodendrocyte Progenitor Cells
    PLoS ONE, 2016-05-18;11(5):e0155227.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTP? Synaptic Adhesion and Intracellular Signaling Pathways
    J Neurosci, 2016-04-27;36(17):4816-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. GDF10 is a signal for axonal sprouting and functional recovery after stroke.
    Authors: Li S, Nie E, Yin Y, Benowitz L, Tung S, Vinters H, Bahjat F, Stenzel-Poore M, Kawaguchi R, Coppola G, Carmichael S
    Nat Neurosci, 2015-10-26;18(12):1737-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  56. Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs.
    Authors: Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, Amano N, Watanabe A, Morimoto M, Takahashi J, Hosoi H, Nakahata T, Inoue H, Saito M
    Stem Cell Reports, 2015-03-19;4(4):561-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Oligodendroglial maturation is dependent on intracellular protein shuttling.
    Authors: Gottle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, Parras C, Kremer D, Hartung H, Cate H, Kury P
    J Neurosci, 2015-01-21;35(3):906-19.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
    Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
    Sci Rep, 2014-09-11;4(0):6330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.
    Authors: Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, Philpott A
    Development, 2014-05-12;141(11):2216-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
    Authors: Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
    Stem Cell Reports, 2014-04-24;2(5):648-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors.
    Authors: Zhou, Zhi, Kohda, Kazuhisa, Ibata, Keiji, Kohyama, Jun, Akamatsu, Wado, Yuzaki, Michisuk, Okano, Hirotaka, Sasaki, Erika, Okano, Hideyuki
    Mol Brain, 2014-04-03;7(0):24.
    Species: Primate - Callitrix jacchus (Common Marmoset)
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury.
    Authors: Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, Sieber-Blum M
    Stem Cells Transl Med, 2014-01-17;3(3):334-45.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Involvement of NT3 and P75(NTR) in photoreceptor degeneration following selective Muller cell ablation.
    Authors: Shen W, Zhu L, Lee S, Chung S, Gillies M
    J Neuroinflammation, 2013-11-14;10(0):137.
    Species: Mouse
    Sample Types: In Vivo
  64. AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy.
    Authors: Sahenk Z, Galloway G, Clark K, Malik V, Rodino-Klapac L, Kaspar B, Chen L, Braganza C, Montgomery C, Mendell J
    Mol Ther, 2013-10-28;22(3):511-21.
    Applications: ELISA (Standard)
  65. Enrichment and characterization of human dermal stem/progenitor cells by intracellular granularity.
    Authors: Shim, Joong Hy, Lee, Tae Ryon, Shin, Dong Woo
    Stem Cells Dev, 2013-01-22;22(8):1264-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Derivation of cerebellar neurons from human pluripotent stem cells.
    Authors: Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya S
    Curr Protoc Stem Cell Biol, 2012-03-01;20(0):1H.51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
    Authors: Demel C, Hoegen T, Giese A
    J Neuroinflammation, 2011-01-24;8(1):7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells.
    Authors: Delcroix GJ, Curtis KM, Schiller PC, Montero-Menei CN
    Differentiation, 2010-09-01;80(4):213-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Neurotrophins modulate monocyte chemotaxis without affecting macrophage function.
    Authors: Samah B, Porcheray F, Gras G
    Clin. Exp. Immunol., 2008-01-08;151(3):476-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.
    Authors: Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP
    Development, 2007-09-01;134(18):3327-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  71. Differentiation of ES cells into cerebellar neurons.
    Authors: Salero E, Hatten ME
    Proc. Natl. Acad. Sci. U.S.A., 2007-02-09;104(8):2997-3002.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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