Recombinant Mouse BMP-4 Protein Summary
Product Specifications
Ser293-Arg408
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
5020-BP
Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
Reconstitution | Reconstitute at 100 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
5020-BP/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
Reconstitution | Reconstitute at 100 μg/mL in 4 mM HCl. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: BMP-4
BMP-4 is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair (1-5). The mouse BMP-4 precursor contains a 273 amino acid (aa) propeptide and a 116 aa mature protein (6). The propeptide is cleaved intracellularly by furin or proprotein convertase 6, enabling the 15 kDa mature BMP-4 monomer to form an active disulfide linked homodimer or heterodimer with BMP-7 (7-9). Mature mouse and human BMP-4 share 98% aa sequence identity. Mouse BMP-4 shares 85% aa sequence identity with mouse BMP-2 and 35%-54% with other mouse BMPs. Compared to BMP-4 homodimers, BMP-4/BMP-7 heterodimers exhibit a greater potency in inducing osteogenic differentiation (9). In Xenopus, the heterodimers can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide ventralizing signals for existing mesoderm (10). BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12). The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans (13-15).
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- Gambaro, K. et al. (2006) Cell Death Differ. 13:1075.
- Simic, P. and S. Vukicevic (2005) Cytokine Growth Factor Rev. 16:299.
- Sadlon, T.J. et al. (2004) Stem Cells 22:457.
- Frank, D.B. et al. (2005) Circ. Res. 97:496.
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- Cui, Y. et al. (1998) EMBO J. 17:4735.
- Cui, Y. et al. (2001) Genes Dev. 15:2797.
- Aono, A. et al. (1995) Biochem. Biophys. Res. Commun. 210:670.
- Nishimatsu, S. and G.H. Thomsen (1998) Mech. Dev. 74:75.
- Chen, D. et al. (2004) Growth Factors 22:233.
- Lavery, K. et al. (2008) J. Biol. Chem. April 24 epub.
- Rosen, V. (2006) Ann. N.Y. Acad. Sci. 1068:19.
- Jones, C.M. and J.C. Smith (1998) Dev. Biol. 194:12.
- Takada, T. et al. (2003) J. Biol. Chem. 278:43229.
Citations for Recombinant Mouse BMP-4 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Transcriptome Analysis of Key Genes Involved in the Initiation of Spermatogonial Stem Cell Differentiation
Authors: Lu, X;Yin, P;Li, H;Gao, W;Jia, H;Ma, W;
Genes
Species: Murine polyomavirus strain A3
Sample Types: Whole Cells
Applications: Bioassay -
Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals
Authors: M Manuel, KB Tan, Z Kozic, M Molinek, TS Marcos, MFA Razak, D Dobolyi, R Dobie, BEP Henderson, NC Henderson, WK Chan, MI Daw, JO Mason, DJ Price
PloS Biology, 2022-09-06;20(9):e3001563.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
White matter damage as a consequence of vascular dysfunction in a spontaneous mouse model of chronic mild chronic hypoperfusion with eNOS deficiency
Authors: X Chen, L Chen, G Lin, Z Wang, MC Kodali, M Li, H Chen, SG Lebovitz, TC Ortyl, L Li, S Ismael, P Singh, KU Malik, T Ishrat, FM Zhou, W Zheng, FF Liao
Molecular Psychiatry, 2022-08-10;0(0):.
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture -
Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells
Authors: T Yamamoto, Z Diao, M Murakami, F Shimokawa, T Matsui, M Funaba
Cytokine, 2022-06-20;157(0):155936.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMP4 drives primed to na�ve transition through PGC-like state
Authors: S Yu, C Zhou, J He, Z Yao, X Huang, B Rong, H Zhu, S Wang, S Chen, X Wang, B Cai, G Zhao, Y Chen, L Xiao, H Liu, Y Qin, J Guo, H Wu, Z Zhang, M Zhang, X Zhao, F Lan, Y Wang, J Chen, S Cao, D Pei, J Liu
Nature Communications, 2022-05-19;13(1):2756.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ultraefficient extracellular vesicle-guided direct reprogramming of fibroblasts into functional cardiomyocytes
Authors: H Kim, BW Song, SJ Park, SW Choi, H Moon, KC Hwang, SW Kang, SH Moon, Y Yang, IC Kwon, SH Kim
Science Advances, 2022-02-25;8(8):eabj6621.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes
Authors: ML Pérez-Loza, L Sudre, S van Eegher, D Citadelle, A Pigenet, MH Lafage-Pro, P Pastoureau, F De Ceuninc, F Berenbaum, X Houard
International Journal of Molecular Sciences, 2022-02-14;23(4):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation
Authors: X Hu, H Wang, GG Tian, C Hou, B Xu, X Zhao, Y Zhao, Q Fang, X Li, L He, X Chen, S Li, J Wu
Cell & bioscience, 2022-01-04;12(1):5.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals
Authors: D Holoch, M Wassef, C Lövkvist, D Zielinski, S Aflaki, B Lombard, T Héry, D Loew, M Howard, R Margueron
Nature Genetics, 2021-11-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Induction of gammadeltaT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells
Authors: N Hosaka, S Kanda, T Shimono, T Nishiyama
Journal of Cellular and Molecular Medicine, 2021-10-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Examining the Developmental Trajectory of an in Vitro Model of Mouse Primordial Germ Cells following Exposure to Environmentally Relevant Bisphenol A Levels
Authors: SKT Ooi, H Jiang, Y Kang, P Allard
Environmental health perspectives, 2021-09-29;129(9):97013.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Visualization of individual cell division history in complex tissues using iCOUNT
Authors: A Denoth-Lip, BN Jaeger, T Liang, LN Royall, SE Chie, K Buthey, D Machado, VI Korobeynyk, M Kruse, CM Munz, A Gerbaulet, BD Simons, S Jessberger
Cell Stem Cell, 2021-09-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
In�vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells
Authors: Y Ishikura, H Ohta, T Sato, Y Murase, Y Yabuta, Y Kojima, C Yamashiro, T Nakamura, T Yamamoto, T Ogawa, M Saitou
Cell Stem Cell, 2021-09-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Derivation of Mouse Parthenogenetic Advanced Stem Cells
Authors: M Wei, J Zhang, J Liu, C Zhao, S Cao, X Yan, B Wu, S Bao
International Journal of Molecular Sciences, 2021-08-20;22(16):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum
Authors: T Zhang, T Liu, N Mora, J Guegan, M Bertrand, X Contreras, AH Hansen, C Streicher, M Anderle, N Danda, L Tiberi, S Hippenmeye, BA Hassan
Cell Reports, 2021-06-08;35(10):109208.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
Authors: PF Xu, RM Borges, J Fillatre, M de Oliveir, T Cheng, B Thisse, C Thisse
Nature Communications, 2021-06-02;12(1):3277.
Species: Mouse
Sample Types: Embryoid Bodies
Applications: Bioassay -
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity
Authors: MK Bin Imtiaz, BN Jaeger, S Bottes, RAC Machado, M Vidmar, DL Moore, S Jessberger
Cell Stem Cell, 2021-02-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver
Authors: R Khatib Sha, J M Hoffmann, S Hedjazifar, L Bonnet, R K Baboota, S Heasman, C Church, I Elias, F Bosch, J Boucher, A Hammarsted, U Smith
PLoS ONE, 2021-02-19;16(2):e0247300.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population
Authors: L Harris, P Rigo, T Stiehl, ZB Gaber, SHL Austin, MDM Masdeu, A Edwards, N Urbán, A Marciniak-, F Guillemot
Cell Stem Cell, 2021-02-12;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone Morphogenetic Proteins Inhibit Ciliogenesis of Ependymal Cells in Vitro
Authors: K Hiraoka, H Inada, K Yanai, N Osumi
Tohoku J Exp Med, 2020-11-01;252(3):199-208.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects
Authors: S Cao, EA Reece, WB Shen, P Yang
Cell Death Dis, 2020-10-15;11(10):859.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts
Authors: L Meng, X Teng, Y Liu, C Yang, S Wang, W Yuan, J Meng, H Chi, L Duan, X Liu
J Am Heart Assoc, 2020-07-31;9(15):e016586.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Variation of Human Neural Stem Cells Generating Organizer States In�Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
Authors: N Micali, SK Kim, M Diaz-Busta, G Stein-O'Br, S Seo, JH Shin, BG Rash, S Ma, Y Wang, NA Olivares, JI Arellano, KR Maynard, EJ Fertig, AJ Cross, RW Bürli, NJ Brandon, DR Weinberger, JG Chenoweth, DJ Hoeppner, N Sestan, P Rakic, C Colantuoni, RD McKay
Cell Rep, 2020-05-05;31(5):107599.
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture -
Engraftment potential of maternal adipose-derived stem cells for fetal transplantation
Authors: A Kawashima, R Yasuhara, R Akino, K Mishima, M Nasu, A Sekizawa
Heliyon, 2020-03-04;6(3):e03409.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice
Authors: JM Hoffmann, JR Grünberg, A Hammarsted, T Kroon, TU Greiner, S Maurer, I Elias, V Palsdottir, F Bosch, J Boucher, S Hedjazifar, U Smith
Mol Metab, 2019-12-17;32(0):15-26.
Species: Mouse
Sample Types:
Applications: Western Blot Control -
Integrative and perturbation based analysis of the transcriptional dynamics of TGFbeta/BMP system components in transition from embryonic stem cells to neural progenitors
Authors: R Dries, A Stryjewska, K Coddens, S Okawa, T Notelaers, J Birkhoff, M Dekker, CM Verfaillie, A Del Sol, E Mulugeta, A Conidi, FG Grosveld, D Huylebroec
Stem Cells, 2019-12-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Authors: Y Koutmani, IA Gampieraki, A Polissidis, M Ximerakis, PN Koutsoudak, A Polyzos, G Agrogianni, S Karaliota, D Thomaidou, LL Rubin, PK Politis, KP Karalis
Cell Rep, 2019-10-22;29(4):932-945.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Effect of EDTA-treated dentin on the differentiation of mouse iPS cells into osteogenic/odontogenic lineages in vitro and in vivo
Authors: T Ser-Od, A Al-Wahabi, K Inoue, K Nakajima, K Matsuzaka, T Inoue
Dent Mater J, 2019-07-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging
Authors: A Lepletier, ML Hun, MV Hammett, K Wong, H Naeem, M Hedger, K Loveland, AP Chidgey
Cell Rep, 2019-06-25;27(13):3887-3901.e4.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMP controls dorsoventral and neural patterning in indirect-developing hemichordates providing insight into a possible origin of chordates
Authors: YH Su, YC Chen, HC Ting, TP Fan, CY Lin, KT Wang, JK Yu
Proc. Natl. Acad. Sci. U.S.A., 2019-06-12;0(0):.
Species: Ptychodera flava, Sea Urchin
Sample Types: Embryo
Applications: In Vivo -
The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ
Authors: I Luque-Moli, Y Shi, Y Abdullah, S Monaco, G Hölzl-Weni, C Mandl, F Ciccolini
Stem Cell Reports, 2019-06-06;13(1):132-146.
Species: Mouse
Sample Types: Whole Cells
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MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis
Authors: M Pons-Espin, C Gasperini, MJ Marzi, C Braccia, A Armirotti, A Pötzsch, TL Walker, K Fabel, F Nicassio, G Kempermann, D De Pietri
Stem Cell Reports, 2019-05-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cluh plays a pivotal role during adipogenesis by regulating the activity of mitochondria
Authors: E Cho, W Jung, HY Joo, ER Park, MY Kim, SB Kim, KS Kim, YB Lim, KH Lee, HJ Shin
Sci Rep, 2019-05-02;9(1):6820.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation
Authors: W Zhang, C Chronis, X Chen, H Zhang, R Spalinskas, M Pardo, L Chen, G Wu, Z Zhu, Y Yu, L Yu, J Choudhary, J Nichols, MM Parast, B Greber, P Sahlén, K Plath
Cell Stem Cell, 2019-01-03;24(1):138-152.e8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells
Authors: RL Wu, G Sedlmeier, L Kyjacova, A Schmaus, J Philipp, W Thiele, BK Garvalov, JP Sleeman
Sci Rep, 2018-10-08;8(1):14913.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions
Authors: K Chanoumido, C Hadjimicha, P Athanasoul, H Ahlenius, A Klonizakis, C Nikolaou, E Drakos, A Kostouros, I Stratidaki, M Grigoriou, A Kretsovali
Sci Rep, 2018-09-13;8(1):13790.
Species: Mouse
Sample Types: Transfected Whole Cells
Applications: Bioassay -
In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects
Authors: A Yoshida, JK Lee, S Tomoyama, K Miwa, K Shirakawa, S Hamanaka, T Yamaguchi, H Nakauchi, S Miyagawa, Y Sawa, I Komuro, Y Sakata
Europace, 2018-09-01;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Precardiac organoids form two heart fields via Bmp/Wnt signaling
Authors: P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon
Nat Commun, 2018-08-07;9(1):3140.
Species: Mouse
Sample Types:
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Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis
Authors: MA Deutsch, SA Doppler, X Li, H Lahm, G Santamaria, G Cuda, S Eichhorn, T Ratschille, E Dzilic, M Dre beta en, A Eckart, K Stark, S Massberg, A Bartels, C Rischpler, R Gilsbach, L Hein, BK Fleischman, SM Wu, R Lange, M Krane
Cardiovasc. Res., 2018-07-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TGF? signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs
Authors: X Yang, R Wang, X Wang, G Cai, Y Qian, S Feng, F Tan, K Chen, K Tang, X Huang, N Jing, Y Qiao
J Mol Cell Biol, 2018-06-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Biophysical subsets of embryonic stem cells display distinct phenotypic and morphological signatures
Authors: T Bongiorno, J Gura, P Talwar, D Chambers, KM Young, D Arafat, G Wang, EL Jackson-Ho, P Qiu, TC McDevitt, T Sulchek
PLoS ONE, 2018-03-08;13(3):e0192631.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Asymmetry between sister cells of pluripotent stem cells at the onset of differentiation
Authors: S Nakamura, A Maruyama, Y Kondo, A Kano, OM De Sousa, M Iwahashi, B Hexig, T Akaike, J Li, Y Hayashi, K Ohnuma
Stem Cells Dev., 2018-02-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mesenchymal Wnt/?-catenin signaling limits tooth number
Authors: E Järvinen, J Shimomura-, A Balic, M Jussila, I Thesleff
Development, 2018-02-21;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
BMP4 signaling in NPCs upregulates Bcl-xL to promote their survival in the presence of FGF-2
Authors: H Yamamoto, M Kurachi, M Naruse, K Shibasaki, Y Ishizaki
Biochem. Biophys. Res. Commun., 2018-01-19;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse
Authors: Y Chen, H Xu, G Lin
Cell Discov, 2017-12-19;3(0):17046.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors
Authors: C Yoon, H Song, T Yin, D Bausch-Flu, AP Frei, S Kattman, N Dubois, AD Witty, JA Hewel, H Guo, A Emili, B Wollscheid, G Keller, PW Zandstra
Stem Cell Reports, 2017-12-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Derivation of hypermethylated pluripotent embryonic stem cells with high potency
Authors: S Bao, WW Tang, B Wu, S Kim, J Li, L Li, T Kobayashi, C Lee, Y Chen, M Wei, S Li, S Dietmann, F Tang, X Li, MA Surani
Cell Res., 2017-10-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue
Authors: SN Kim, HJ Kwon, SW Im, YH Son, S Akindehin, YS Jung, SJ Lee, IJ Rhyu, IY Kim, JK Seong, J Lee, HC Yoo, JG Granneman, YH Lee
Sci Rep, 2017-08-02;7(1):7159.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hierarchical patterning modes orchestrate hair follicle morphogenesis
Authors: JD Glover, KL Wells, F Matthäus, KJ Painter, W Ho, J Riddell, JA Johansson, MJ Ford, CAB Jahoda, V Klika, RL Mort, DJ Headon
PLoS Biol., 2017-07-11;15(7):e2002117.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice
Authors: J Feng, J Jing, J Li, H Zhao, V Punj, T Zhang, J Xu, Y Chai
Development, 2017-06-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The BMP4-Smad Signaling Pathway Regulates Hyperandrogenism Development in a Female Mouse Model
Authors: Y Liu, SY Du, M Ding, X Dou, FF Zhang, ZY Wu, SW Qian, W Zhang, QQ Tang, CJ Xu
J. Biol. Chem., 2017-06-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate
Authors: H Ohta, K Kurimoto, I Okamoto, T Nakamura, Y Yabuta, H Miyauchi, T Yamamoto, Y Okuno, M Hagiwara, K Shirane, H Sasaki, M Saitou
EMBO J., 2017-05-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ATOH1 promotes leptomeningeal dissemination and metastasis of Sonic Hedgehog subgroup medulloblastomas
Authors: KB Grausam, SD Dooyema, L Bihannic, H Premathila, AS Morrissy, A Forget, AM Schaefer, JH Gundelach, S Macura, DM Maher, X Wang, AH Heglin, X Ge, E Zeng, S Puget, I Chandrasek, K Surendran, RJ Bram, U Schüller, MD Taylor, O Ayrault, H Zhao
Cancer Res., 2017-05-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Collagen-alginate microspheres as a 3D culture system for mouse embryonic stem cells differentiation to primordial germ cells
Authors: V Mansouri, M Salehi, MD Omrani, Z Niknam, A Ardeshiryl
Biologicals, 2017-05-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs
Authors: JM Brunger, A Zutshi, VP Willard, CA Gersbach, F Guilak
Stem Cell Reports, 2017-04-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells
Authors: Y Han, J Ren, E Lee, X Xu, W Yu, K Muegge
Sci Rep, 2017-04-25;7(1):1136.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Kielin/chordin-like Protein (KCP) Attenuates High Fat Diet Induced Obesity and Metabolic Syndrome in Mice
Authors: A Soofi, KI Wolf, MP Emont, N Qi, G Martinez-S, E Grimley, W Ostwani, GR Dressler
J. Biol. Chem., 2017-04-19;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice
Authors: Y Li, S Tian, I Lei, L Liu, P Ma, Z Wang
Am J Transl Res, 2017-03-15;9(3):1530-1542.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
Authors: N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli
Nat Commun, 2017-02-13;8(0):14127.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phenolics and neolignans isolated from the fruits of Juglans mandshurica Maxim. and their effects on lipolysis in adipocytes
Authors: S Park, N Kim, G Yoo, SN Kim, HJ Kwon, K Jung, DC Oh, YH Lee, SH Kim
Phytochemistry, 2017-02-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells
Authors: T Jiajie, Y Yanzhou, AC Hoi-Hung, C Zi-Jiang, C Wai-Yee
Sci Rep, 2017-01-23;7(0):41304.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
In�Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells
Cell Rep, 2016-12-06;17(10):2789-2804.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transformation of jaw muscle satellite cells to cardiomyocytes
Authors: Randall S Daughters
Differentiation, 2016-12-03;93(0):58-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Multifactorial Optimizations for Directing Endothelial Fate from Stem Cells
PLoS ONE, 2016-12-01;11(12):e0166663.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Native thymic extracellular matrix improves in�vivo thymic organoid T cell output, and drives in�vitro thymic epithelial cell differentiation
Authors: Michael Hun
Biomaterials, 2016-11-30;118(0):1-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Development-on-chip: in vitro neural tube patterning with a microfluidic device
Authors: Christopher J Demers
Development, 2016-06-01;143(11):1884-92.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis
Authors: J Lee, S Kang, KC Lilja, KJ Colletier, CJ Scheitz, YV Zhang, T Tumbar
Nat Commun, 2016-04-15;7(0):11278.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
Authors: Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
Stem Cells, 2015-03-01;33(3):742-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Functional cardiomyocytes derived from Isl1 cardiac progenitors via Bmp4 stimulation.
Authors: Cagavi E, Bartulos O, Suh C, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y
PLoS ONE, 2014-12-18;9(12):e110752.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.
Authors: Sun C, Yu D, Ye W, Liu C, Gu S, Sinsheimer N, Song Z, Li X, Chen C, Song Y, Wang S, Schrader L, Chen Y
J Biol Chem, 2014-12-08;290(4):2007-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.
Authors: Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T
Biochem Biophys Res Commun, 2014-11-15;455(3):347-52.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endoderm generates endothelial cells during liver development
Stem Cell Reports, 2014-09-18;3(4):556-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and beta-catenin signaling.
Authors: Xu H, Tsang K, Wang Y, Chan J, Xu G, Gao W
J Biol Chem, 2014-08-04;289(38):26290-301.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
3D niche microarrays for systems-level analyses of cell fate.
Authors: Ranga A, Gobaa S, Okawa Y, Mosiewicz K, Negro A, Lutolf M
Nat Commun, 2014-07-14;5(0):4324.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway.
Authors: Tanwar V, Bylund J, Hu J, Yan J, Walthall J, Mukherjee A, Heaton W, Wang W, Potet F, Rai M, Kupershmidt S, Knapik E, Hatzopoulos A
Stem Cells, 2014-07-01;32(7):1774-88.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways.
Authors: Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J, Li J, Jing N
Elife, 2014-06-14;3(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Signaling mechanisms that suppress the cytostatic actions of rapamycin.
Authors: Jahn S, Law M, Corsino P, Davis B, Harrison J, Law B
PLoS ONE, 2014-06-13;9(6):e99927.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.
Authors: Onishi K, Tonge P, Nagy A, Zandstra P
Stem Cell Reports, 2014-06-06;3(1):156-68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Generation of organized germ layers from a single mouse embryonic stem cell.
Authors: Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N
Nat Commun, 2014-05-30;5(0):4000.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis.
Authors: Li H, Yue R, Wei B, Gao G, Du J, Pei G
EMBO J, 2014-05-14;33(12):1383-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
Authors: Chong J, Yang X, Don C, Minami E, Liu Y, Weyers J, Mahoney W, Van Biber B, Cook S, Palpant N, Gantz J, Fugate J, Muskheli V, Gough G, Vogel K, Astley C, Hotchkiss C, Baldessari A, Pabon L, Reinecke H, Gill E, Nelson V, Kiem H, Laflamme M, Murry C
Nature, 2014-04-30;510(7504):273-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.
Authors: Xiao, Yanping, Yu, Sanhong, Zhu, Baogong, Bedoret, Denis, Bu, Xia, Francisco, Loise M, Hua, Ping, Duke-Cohan, Jonathan, Umetsu, Dale T, Sharpe, Arlene H, DeKruyff, Rosemari, Freeman, Gordon J
J Exp Med, 2014-04-21;211(5):943-59.
Species: Mouse
Sample Types: Antibody
Applications: ELISA (Capture) -
Manipulating gene expression and signaling activity in cultured mouse limb bud cells.
Authors: Lewandowski J, Pursell T, Rabinowitz A, Vokes S
Dev Dyn, 2014-04-17;243(7):928-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A novel, visible light-induced, rapidly cross-linkable gelatin scaffold for osteochondral tissue engineering.
Authors: Mazaki T, Shiozaki Y, Yamane K, Yoshida A, Nakamura M, Yoshida Y, Zhou D, Kitajima T, Tanaka M, Ito Y, Ozaki T, Matsukawa A
Sci Rep, 2014-03-25;4(0):4457.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay -
Determining cell division symmetry through the dissection of dividing cells using single-cell expression analysis.
Authors: Jasnos, Lukasz, Sawado, Tomoyuki
Nat Protoc, 2014-02-06;9(3):505-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity.
Authors: Yap C, Goh H, Familari M, Rathjen P, Rathjen J
J Cell Sci, 2014-01-30;127(0):2204-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Epigenetic regulation of sensory axon regeneration after spinal cord injury.
Authors: Finelli M, Wong J, Zou H
J Neurosci, 2013-12-11;33(50):19664-76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.
Authors: Nishino, Jinsuke, Kim, Sunjung, Zhu, Yuan, Zhu, Hao, Morrison, Sean J
Elife, 2013-11-05;2(0):e00924.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Defined extracellular matrix components are necessary for definitive endoderm induction.
Authors: Taylor-Weiner H, Schwarzbauer J, Engler A
Stem Cells, 2013-10-01;31(10):2084-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells.
Authors: Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L
Exp Cell Res, 2013-09-27;320(1):54-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identifying division symmetry of mouse embryonic stem cells: negative impact of DNA methyltransferases on symmetric self-renewal.
Authors: Jasnos L, Aksoy F, Hersi H, Wantuch S, Sawado T
Stem Cell Reports, 2013-09-26;1(4):360-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.
Authors: Tsuchida, R, Osawa, T, Wang, F, Nishii, R, Das, B, Tsuchida, S, Muramatsu, M, Takahashi, T, Inoue, T, Wada, Y, Minami, T, Yuasa, Y, Shibuya, M
Oncogene, 2013-09-09;33(29):3803-11.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog.
Authors: Karwacki-Neisius V, Goke J, Osorno R, Halbritter F, Ng J, Weisse A, Wong F, Gagliardi A, Mullin N, Festuccia N, Colby D, Tomlinson S, Ng H, Chambers I
Cell Stem Cell, 2013-05-02;12(5):531-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
Authors: Najm, Fadi J, Lager, Angela M, Zaremba, Anita, Wyatt, Krysta, Caprariello, Andrew V, Factor, Daniel C, Karl, Robert T, Maeda, Tadao, Miller, Robert H, Tesar, Paul J
Nat Biotechnol, 2013-04-14;31(5):426-33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Specialized tip/stalk-like and phalanx-like endothelial cells from embryonic stem cells.
Authors: Blancas A, Wong L, Glaser D, McCloskey K
Stem Cells Dev, 2013-02-12;22(9):1398-407.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis.
Authors: Qian S, Tang Y, Li X, Liu Y, Zhang Y, Huang H, Xue R, Yu H, Guo L, Gao H, Liu Y, Sun X, Li Y, Jia W, Tang Q
Proc Natl Acad Sci U S A, 2013-02-06;110(9):E798-807.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth.
Authors: Sakaguchi, Masaji, Sharmin, Sazia, Taguchi, Atsuhiro, Ohmori, Tomoko, Fujimura, Sayoko, Abe, Takaya, Kiyonari, Hiroshi, Komatsu, Yoshihir, Mishina, Yuji, Asashima, Makoto, Araki, Eiichi, Nishinakamura, Ryuichi
Nat Commun, 2013-01-01;4(0):1398.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
Authors: Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing
Nat Genet, 2012-12-02;45(1):34-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Opposing Nodal and BMP Signals Regulate Left-Right Asymmetry in the Sea Urchin Larva.
Authors: Luo, Yi-Jyun, Su, Yi-Hsien
PLoS Biol, 2012-10-09;10(10):e1001402.
Species: Sea Urchin
Sample Types: Whole Cells
Applications: Bioassay -
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
Nature, 2012-10-07;491(7426):765-8.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo.
Authors: Ueki Y, Reh TA
PLoS ONE, 2012-06-06;7(6):e38690.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
Stem Cells, 2011-06-01;29(6):964-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
Development, 2010-03-01;137(5):693-704.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade.
Authors: Du Y, Xiao Q, Yip HK
Invest. Ophthalmol. Vis. Sci., 2010-02-03;51(7):3764-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.
Authors: Strissel KJ, DeFuria J, Shaul ME, Bennett G, Greenberg AS, Obin MS
Obesity (Silver Spring), 2010-01-28;18(10):1918-25.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro.
Authors: Hayashi K, Surani MA
Development, 2009-09-30;136(21):3549-56.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
Dev. Biol., 2009-04-07;330(2):286-304.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling.
Authors: Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C
J. Cell Biol., 2009-02-16;184(4):597-609.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
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Reason for Rating: Reproducible results