Recombinant Mouse CCL7/MARC Protein Summary
Product Specifications
Gln24-Pro97
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
456-MC
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile, deionized water. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
456-MC/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile, deionized water. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: CCL7/MCP-3/MARC
Mouse MARC, a member of the beta subfamily of chemokines, was initially identified as a transcript that is induced in a mouse mast cell line after Fc epsilon RI triggering by IgE plus antigen. Sequence comparisons suggest that MARC may be the mouse homologue of the human MCP-3 gene. Mouse MARC/MCP-3 expression has also been detected during murine experimental allergic encephalomyelitis in the spinal cord, and in LPS-stimulated murine WEHI -3 cells and Swiss 3T3 cells where MARC expression is glucocorticoid-attenuated. Except for one amino acid subsititution, mouse MARC is identical to mouse FIC, the product of a growth factor-activated gene. The mouse MARC cDNA encodes a 97 amino acid residue precursor protein with a 23 amino acid residue signal peptide that is cleaved to yield a 74 amino acid residue mature protein. Mouse CCR2, a mouse chemokine receptor, has been shown to bind JE/MCP-1 with high affinity and MARC/MCP-3 with lower affinity. The E. coli-expressed mouse MARC/MCP-3 produced at R&D Systems has been shown to be a monocyte and T-lymphocyte chemoattractant.
- Kulmburg, P.A. et al. (1992) J. Exp. Med. 176:1773.
- Thirion, S. et al. (1994) Biochem. Biophys. Res. Commun. 201:493.
- Smith, J.B. and H.R. Herschman (1995) J. Biol. Chem. 270:16756.
- Kurihara, T. and R. Bravo (1996) J. Biol. Chem. 271:11603.
Citations for Recombinant Mouse CCL7/MARC Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function
Authors: Z Su, J Brooks, J Pelker, T Andreyeva, H Sobon, R Gifford, M Powers, J Wang, C Dower, M Hegen, D Messing, AD Sheehan, JJ Brennan
PLoS ONE, 2023-01-20;18(1):e0280590.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay -
-->The CCL2/CCL7/CCL12/CCR2 pathway is substantially and persistently upregulated in mice after traumatic brain injury, and CCL2 modulates the complement system in microglia
Authors: K Popiolek-B, A Ciechanows, K Ciapa?a, K Pawlik, M Oggioni, D Mercurio, MG De Simoni, J Mika
Mol Cell Probes, 2020-11-04;54(0):101671.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes
Authors: N Gomez-Lope, M Arenas-Her, R Romero, D Miller, V Garcia-Flo, Y Leng, Y Xu, J Galaz, SS Hassan, CD Hsu, H Tse, C Sanchez-To, B Done, AL Tarca
Cell Rep, 2020-07-07;32(1):107874.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia
Authors: K Kwiatkowsk, K Popiolek-B, A Piotrowska, E Rojewska, K Ciapa?a, W Makuch, J Mika
Cytokine, 2019-04-16;119(0):202-213.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis
Authors: Chuan-Hui Kuo
J. Immunol, 2016-12-12;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Defective TGF-beta signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors.
Authors: Fan Q, Gu D, Liu H, Yang L, Zhang X, Yoder M, Kaplan M, Xie J
Cancer Res, 2013-11-26;74(2):471-83.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
Blood, 2004-09-09;105(1):31-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells.
Authors: Carrillo A, Monreal Y, Ramirez P, Marin L, Parrilla P, Oliver FJ, Yelamos J
Nucleic Acids Res., 2004-02-03;32(2):757-66.
Applications: ELISA (Standard)
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