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Recombinant Mouse Flt-3 Ligand/FLT3L Protein

Catalog #: 427-FL
89 Citations Datasheet / COA / SDS
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Carrier Free

Catalog # Availability Size / Price Qty
427-FL-005/CF
427-FL-025/CF

With Carrier

Catalog # Availability Size / Price Qty
427-FL-005
427-FL-025
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Recombinant Mouse Flt-3 Ligand/FLT3L Protein Bioactivity
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Citations (89)
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse Flt-3 Ligand/FLT3L Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with mouse Flt-3. The ED50 for this effect is typically 0.4-2.4 ng/mL.
Source
Mouse myeloma cell line, NS0-derived mouse Flt-3 Ligand/FLT3L protein
Gly27-Arg188
Accession #
P49772.1
N-terminal Sequence
Analysis
Gly27
Predicted Molecular Mass
18 kDa
SDS-PAGE
Multiple bands between 18-32 kDa, reducing conditions

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427-FL (with carrier)

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427-FL/CF (carrier free)

Product Datasheet
COA
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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

427-FL

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

427-FL/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 50 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse Flt-3 Ligand/FLT3L Protein Bioactivity View Larger

Recombinant Mouse Flt-3 Ligand/FLT3L (Catalog # 427-FL) stimulates cell proliferation in the BaF3 mouse pro-B cell line transfected with mouse Flt-3. The ED50 for this effect is 0.4-2.4 ng/mL.

SDS-PAGE Recombinant Mouse Flt-3 Ligand/FLT3L Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse Flt-3 Ligand/FLT3L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing multiple bands between 18-32 kDa. Multiple bands are due to variable glycosylation of the protein.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Flt-3 Ligand/FLT3L

Flt-3 Ligand, also known as FLT3L, is an alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages (1-3). Mature mouse Flt‑3 Ligand consists of a 161 amino acid (aa) extracellular domain (ECD) with a cytokine-like domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 22 aa cytoplasmic tail (4-6). Within the ECD, mouse Flt-3 Ligand shares 71% and 81% aa sequence identity with human and rat Flt-3 Ligand, respectively. The mouse and human Flt-3 Ligand proteins show cross-species activity (4, 5, 7). Flt-3 Ligand is also structurally related to M-CSF and SCF. Flt-3 Ligand is widely expressed in various mouse and human tissues. Flt-3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts (1, 8). Each 36 kDa chain of the Flt-3 Ligand dimer carries approximately 12 kDa of N- and O‑linked carbohydrates (8). Alternate splicing and proteolytic cleavage of the transmembrane form of the Flt-3 Ligand protein can generate a soluble 30 kDa fragment that includes the cytokine-like domain (4, 8). Alternate splicing of mouse Flt-3 Ligand also generates a membrane-associated isoform with a 57 aa substitution following the cytokine-like domain in the ECD of the Flt-3 Ligand protein (4, 5, 8, 9). Both transmembrane and soluble Flt-3 Ligand signal through the tyrosine kinase receptor Flt-3/Flk-2 (3 - 6). Flt-3 Ligand induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation (2, 10). Additionally, Flt-3 Ligand synergizes with IL-3, GM‑CSF, and SCF to promote the mobilization and myeloid differentiation of hematopoietic stem cells (4, 5, 7). Flt-3 Ligand also cooperates with IL‑2, IL-6, IL-7, and IL-15 to induce NK cell development and with IL-3, IL-7, and IL‑11 to induce terminal B cell maturation (1, 11). Animal studies also show that Flt-3 Ligand reduces the severity of experimentally induced allergic inflammation (12).

References
  1. Wodnar-Filipowicz, A. (2003) News Physiol. Sci. 18:247.
  2. Dong, J. et al. (2002) Cancer Biol. Ther. 1:486.
  3. Gilliland, D.G. and J.D. Griffin (2002) Blood 100:1532.
  4. Hannum, C. et al. (1994) Nature 368:643.
  5. Lyman, S.D. et al. (1993) Cell 75:1157.
  6. Savvides, S.N. et al. (2000) Nat. Struct. Biol. 7:486.
  7. Lyman, S.D. et al. (1994) Blood 83:2795.
  8. McClanahan, T. et al. (1996) Blood 88:3371.
  9. Lyman, S.D. et al. (1995) Oncogene 10:149.
  10. Diener, K.R. et al. (2008) Exp. Hematol. 36:51.
  11. Farag, S.S. and M.A. Caligiuri (2006) Blood Rev. 20:123.
  12. Edwan, J.H. et al. (2004) J. Immunol. 172:5016.
Long Name
fms-like Tyrosine Kinase 3 Ligand
Entrez Gene IDs
2323 (Human); 14256 (Mouse); 102125470 (Cynomolgus Monkey); 493796 (Feline)
Alternate Names
FL; FLG3L; Flt3 ligand; Flt-3 Ligand; Flt3L; FLT3LG; fms-related tyrosine kinase 3 ligand; SL cytokine

Citations for Recombinant Mouse Flt-3 Ligand/FLT3L Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

89 Citations: Showing 1 - 10
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  1. Dendritic Cell - Fibroblast Crosstalk via TLR9 and AHR Signaling Drives Lung Fibrogenesis
    Authors: Carter, H;Costa, RM;Adams, TS;Gilchrist, T;Emch, CE;Bame, M;Oldham, JM;Linderholm, AL;Noth, I;Kaminski, N;Moore, BB;Gurczynski, SJ;
    bioRxiv : the preprint server for biology
    Species: Murine polyomavirus strain A3
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1
    Authors: X Cui, C Zhang, F Wang, X Zhao, S Wang, J Liu, D He, C Wang, FC Yang, S Tong, Y Liang
    Cell Reports, 2023-03-16;42(3):112274.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity
    Authors: J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao
    Cell Reports, 2023-01-18;42(1):111991.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia
    Authors: X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama
    Embo Molecular Medicine, 2022-12-01;0(0):e15631.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  5. Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) content
    Authors: M Uslu, E Albayrak, F Kocaba?
    International immunopharmacology, 2022-07-11;110(0):109035.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis
    Authors: Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura
    Cell Reports, 2022-05-10;39(6):110805.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells
    Authors: J Jeong, I Jung, JH Kim, S Jeon, DY Hyeon, H Min, B Kang, J Nah, D Hwang, SJ Um, M Ko, RH Seong
    Cell Death and Differentiation, 2022-04-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells
    Authors: K Yamamoto, S Goyama, S Asada, T Fujino, T Yonezawa, N Sato, R Takeda, A Tsuchiya, T Fukuyama, Y Tanaka, A Yokoyama, H Toya, A Kon, Y Nannya, R Onoguchi-M, S Nakagawa, T Hirose, S Ogawa, N Akimitsu, T Kitamura
    Cell Reports, 2021-08-24;36(8):109576.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS
    Authors: N Ohashi, T Terashima, M Katagi, Y Nakae, J Okano, Y Suzuki, H Kojima
    Scientific Reports, 2021-06-17;11(1):12803.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  10. The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision
    Authors: F Herbst, TJL Lang, ESP Eckert, P Wünsche, AA Wurm, T Kindinger, K Laaber, S Hemmati, A Hotz-Wagen, O Zavidij, A Paruzynski, J Lu, C von Kalle, T Zenz, C Klein, M Schmidt, CR Ball, H Glimm
    Leukemia, 2021-05-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging
    Authors: J Lu, S Li, X Li, W Zhao, X Duan, X Gu, J Xu, B Yu, LJ Sigal, Z Dong, L Xie, M Fang
    Aging Cell, 2021-03-29;0(0):e13353.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo
    Authors: V Tereshchen, A Bulygin, R Zavodskii, A Maksyutov, V Kurilin, M Fisher, N Semenyuk, S Aladev, S Sennikov
    Cytokine, 2021-02-26;142(0):155473.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. The E protein-TCF1 axis controls &gamma&delta T�cell development and effector fate
    Authors: SP Fahl, AV Contreras, A Verma, X Qiu, C Harly, F Radtke, JC Zúñiga-Pfl, C Murre, HH Xue, JM Sen, DL Wiest
    Cell Reports, 2021-02-02;34(5):108716.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Stem cell transplantation uncovers TDO-AHR regulation of lung dendritic cells in herpesvirus-induced pathology
    Authors: SJ Gurczynski, NL Pereira, SM Hrycaj, C Wilke, RL Zemans, BB Moore
    JCI Insight, 2021-01-25;6(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
    Authors: NE Papaioanno, N Salei, S Rambichler, K Ravi, J Popovic, V Küntzel, CHK Lehmann, R Fiancette, J Salvermose, DW Gajdasik, R Mettler, D Messerer, J Carrelha, C Ohnmacht, D Haller, R Stumm, T Straub, SEW Jacobsen, C Schulz, DR Withers, G Schotta, D Dudziak, BU Schraml
    Nature Communications, 2021-01-19;12(1):464.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System
    Authors: Y Hong, N Singh, S Bamopoulos, E Gjerga, LK Schmalbroc, K Balabanian, M Schick, U Keller, M Wirth
    Biomedicines, 2020-12-09;8(12):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro
    Authors: M Girotra, V Trachsel, A Roch, MP Lutolf
    Int J Mol Sci, 2020-11-03;21(21):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. Ex�Vivo Gene Therapy Treats Bone Complications of Mucopolysaccharidosis Type II Mouse Models through Bone Remodeling Reactivation
    Authors: M Wada, Y Shimada, S Iizuka, N Ishii, H Hiraki, T Tachibana, K Maeda, M Saito, S Arakawa, T Ishimoto, T Nakano, H Ida, T Ohashi, H Kobayashi
    Mol Ther Methods Clin Dev, 2020-09-20;19(0):261-274.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus
    Authors: NV Bogert, J Furkel, S Din, I Braren, V Eckstein, JA Müller, L Uhlmann, HA Katus, MH Konstandin
    Sci Rep, 2020-08-13;10(1):13740.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID
    Authors: L Garcia-Per, M van Eggerm, L van Roon, SA Vloemans, M Cordes, A Schambach, M Rothe, D Berghuis, C Lagresle-P, M Cavazzana, F Zhang, AJ Thrasher, D Salvatori, P Meij, A Villa, JJM Van Dongen, JJ Zwaginga, M van der Bu, HB Gaspar, A Lankester, FJT Staal, K Pike-Overz
    Mol Ther Methods Clin Dev, 2020-03-31;17(0):666-682.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis
    Authors: Y Zhao, J Wang, Z Min, L Peng, S Qi, W Lin
    Mediators Inflamm., 2020-03-10;2020(0):6947482.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
    Authors: JM Bertho, D Kereselidz, L Manens, C Culeux, V Magneron, J Surette, M Blimkie, L Bertrand, H Wyatt, M Souidi, I Dublineau, N Priest, JR Jourdain
    Sci Rep, 2019-12-27;9(1):19919.
    Species: Mouse
    Sample Types: Plasma
    Applications: Multiplex Assay
  23. RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors
    Authors: ELY Chen, PK Thompson, JC Zúñiga-Pfl
    Nat. Immunol., 2019-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development
    Authors: Z Gong, B Shang, Y Chu, X Chen, Q Li, K Liu, Y Chen, Y Huang, Y Han, Q Shang, Z Zheng, L Song, Y Li, R Liu, C Xu, X Zhang, B Liu, L Wang, C Shao, Y Wang, Y Shi
    Cell Death Dis, 2019-06-05;10(6):440.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Interleukin-33 regulates hematopoietic stem cell regeneration after radiation injury
    Authors: P Huang, X Li, Y Meng, B Yuan, T Liu, M Jiao, X Wang, Y Liu, H Yin
    Stem Cell Res Ther, 2019-04-18;10(1):123.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
    Authors: N Vannini, V Campos, M Girotra, V Trachsel, S Rojas-Sutt, J Tratwal, S Ragusa, E Stefanidis, D Ryu, PY Rainer, G Nikitin, S Giger, TY Li, A Semilietof, A Oggier, Y Yersin, L Tauzin, E Pirinen, WC Cheng, J Ratajczak, C Canto, M Ehrbar, F Sizzano, TV Petrova, D Vanhecke, L Zhang, P Romero, A Nahimana, S Cherix, MA Duchosal, PC Ho, B Deplancke, G Coukos, J Auwerx, MP Lutolf, O Naveiras
    Cell Stem Cell, 2019-03-07;24(3):405-418.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
    Authors: S Goossens, J Wang, C Tremblay, J De Medts, S T'Sas, T Nguyen, J Saw, K Haigh, DJ Curtis, P Van Vlierb, G Berx, T Taghon, JJ Haigh
    Haematologica, 2019-01-24;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome
    Authors: F Ribezzo, IAM Snoeren, S Ziegler, J Stoelben, PA Olofsen, A Henic, MV Ferreira, S Chen, USA Stalmann, G Buesche, RM Hoogenboez, R Kramann, U Platzbecke, MHGP Raaijmaker, BL Ebert, RK Schneider
    Leukemia, 2019-01-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy
    Authors: F Boscolo Se, D Fox, A Sacco
    Cell Rep, 2019-01-15;26(3):689-701.e6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Arginine methylation controls the strength of ?c-family cytokine signaling in T cell maintenance
    Authors: M Inoue, K Okamoto, A Terashima, T Nitta, R Muro, T Negishi-Ko, T Kitamura, T Nakashima, H Takayanagi
    Nat. Immunol., 2018-10-15;19(11):1265-1276.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
    Authors: SK Martin, S Fitter, N El Khawank, RH Grose, CR Walkley, LE Purton, MA Ruegg, MN Hall, S Gronthos, ACW Zannettino
    Sci Rep, 2018-09-28;8(1):14501.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition
    Authors: R Gonzalez-Q, A Nguyen, DH Kono, MBA Oldstone, AN Theofilopo, R Baccala
    PLoS ONE, 2018-09-10;13(9):e0203118.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses
    Authors: YW Lin, LC Wang, CK Lee, SH Chen
    Sci Rep, 2018-08-15;8(1):12184.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells
    Authors: SH Kim, SW Lee, HJ Park, SH Lee, WK Im, YD Kim, KH Kim, SJ Park, S Hong, SH Jeon
    BMC Complement Altern Med, 2018-07-18;18(1):218.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Acutely malnourished weanling mice administered Flt3 ligand can support a cell-mediated inflammatory response
    Authors: LM Hillyer, B Woodward
    Cytokine, 2018-07-07;113(0):39-49.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard), Western Blot
  36. Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs
    Authors: P Wünsche, ESP Eckert, T Holland-Le, A Paruzynski, A Hotz-Wagen, R Fronza, T Rath, I Gil-Farina, M Schmidt, C von Kalle, C Klein, CR Ball, F Herbst, H Glimm
    Cell Stem Cell, 2018-07-05;23(1):132-146.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells
    Authors: SK Tasian, JA Casas, D Posocco, S Gandre-Bab, AL Gagne, G Liang, ML Loh, MJ Weiss, DL French, ST Chou
    Leukemia, 2018-06-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Wild-type Kras expands and exhausts hematopoietic stem cells
    Authors: JP Sasine, HA Himburg, CM Termini, M Roos, E Tran, L Zhao, J Kan, M Li, Y Zhang, SC de Barros, DS Rao, CM Counter, JP Chute
    JCI Insight, 2018-06-07;3(11):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
    Authors: GH Nam, EJ Lee, YK Kim, Y Hong, Y Choi, MJ Ryu, J Woo, Y Cho, DJ Ahn, Y Yang, IC Kwon, SY Park, IS Kim
    Nat Commun, 2018-06-04;9(1):2165.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment
    Authors: LC Cheung, J Tickner, AM Hughes, P Skut, M Howlett, B Foley, J Oommen, JE Wells, B He, S Singh, GA Chua, J Ford, CG Mullighan, RS Kotecha, UR Kees
    Leukemia, 2018-05-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Global H3.3 dynamic deposition defines its bimodal role in cell fate transition
    Authors: HT Fang, CA El Farran, QR Xing, LF Zhang, H Li, B Lim, YH Loh
    Nat Commun, 2018-04-18;9(1):1537.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate
    Authors: M Kanayama, Y Kato, T Tsuji, Y Konoeda, A Hashimoto, O Kanauchi, T Fujii, D Fujiwara
    Sci Rep, 2018-02-16;8(1):3147.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Macrophages and osteoclasts stem from a bipotent progenitor downstream of a macrophage/osteoclast/dendritic cell progenitor
    Authors: Y Xiao, J Palomero, J Grabowska, L Wang, I de Rink, L van Helver, J Borst
    Blood Adv, 2017-10-13;1(23):1993-2006.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  44. T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction
    Authors: MJ Smith, DK Reichenbac, SL Parker, MJ Riddle, J Mitchell, KC Osum, M Mohtashami, HE Stefanski, BT Fife, A Bhandoola, KA Hogquist, GA Holländer, JC Zúñiga-Pfl, J Tolar, BR Blazar
    JCI Insight, 2017-05-18;2(10):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease
    Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
    Mol Ther Methods Clin Dev, 2017-05-12;5(0):241-258.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs
    Authors: S Ma, X Wan, Z Deng, L Shi, C Hao, Z Zhou, C Zhou, Y Fang, J Liu, J Yang, X Chen, T Li, A Zang, S Yin, B Li, J Plumas, L Chaperot, X Zhang, G Xu, L Jiang, N Shen, S Xiong, X Gao, Y Zhang, H Xiao
    J. Exp. Med., 2017-04-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
    Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
    Nat. Methods, 2017-04-10;14(5):531-538.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Differential Cultivation of Francisella tularensis Induces Changes in the Immune Response to and Protective Efficacy of Whole Cell-Based Inactivated Vaccines
    Authors: S Kumar, R Sunagar, G Pham, BJ Franz, SJ Rosa, KR Hazlett, EJ Gosselin
    Front Immunol, 2017-01-10;7(0):677.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
    Nat. Med, 2016-12-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis
    Cell Death Dis, 2016-11-24;7(11):e2479.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors
    Nat Commun, 2016-11-21;7(0):13396.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development
    Authors: L Zhao, RL Frock, Z Du, J Hu, L Chen, MS Krangel, FW Alt
    J. Exp. Med, 2016-08-15;213(9):1921-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Hepatitis C Virus Stimulates Murine CD8?-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner
    PLoS Pathog, 2016-07-06;12(7):e1005736.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus
    Authors: Ahmed S Elshikha
    PLoS ONE, 2016-05-27;11(5):e0156583.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis
    PLoS ONE, 2016-05-09;11(5):e0154630.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
    Nat. Med., 2016-05-02;22(6):672-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production.
    Authors: Niedzielska M, Raffi F, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt U, Wirtz S, Sparwasser T, Hochrein H, Figdor C, Keyse S, Lang R
    J Immunol, 2015-07-13;195(4):1753-62.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  58. Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.
    Authors: Lee S, Park H, Jeon S, Lee C, Seong R, Park S, Hong S
    PLoS ONE, 2015-07-06;10(7):e0132329.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. FcgammaRIIB prevents inflammatory type I IFN production from plasmacytoid dendritic cells during a viral memory response.
    Authors: Flores M, Chew C, Tyan K, Huang W, Salem A, Clynes R
    J Immunol, 2015-03-27;194(9):4240-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells.
    Authors: Rommler F, Hammel M, Waldhuber A, Muller T, Jurk M, Uhlmann E, Wagner H, Vollmer J, Miethke T
    PLoS ONE, 2015-02-19;10(2):e0116703.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  61. High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus.
    Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M
    J Virol, 2015-01-21;89(7):3859-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Lignin-rich enzyme lignin (LREL), a cellulase-treated lignin-carbohydrate derived from plants, activates myeloid dendritic cells via Toll-like receptor 4 (TLR4).
    J Biol Chem, 2014-12-29;290(0):4410-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice.
    Authors: Martinez-Lopez M, Iborra S, Conde-Garrosa R, Sancho D
    Eur J Immunol, 2014-11-28;45(1):119-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.
    Authors: Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M
    Blood, 2014-07-02;124(9):1393-403.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
    Authors: Patnode M, Bando J, Krummel M, Locksley R, Rosen S
    J Exp Med, 2014-06-02;211(7):1281-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.
    Authors: Dai P, Wang W, Cao H, Avogadri F, Dai L, Drexler I, Joyce J, Li X, Chen Z, Merghoub T, Shuman S, Deng L
    PLoS Pathog, 2014-04-17;10(4):e1003989.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential.
    Authors: Treanor L, Zhou S, Janke L, Churchman M, Ma Z, Lu T, Chen S, Mullighan C, Sorrentino B
    J Exp Med, 2014-03-31;211(4):701-13.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.
    Authors: Wallington-Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L
    Cancer Res, 2014-03-31;74(10):2803-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.
    Authors: Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, Hough M, Chen E
    PLoS ONE, 2014-02-26;9(2):e89649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. The TCR ligand-inducible expression of CD73 marks gammadelta lineage commitment and a metastable intermediate in effector specification.
    Authors: Coffey F, Lee S, Buus T, Lauritsen J, Wong G, Joachims M, Thompson L, Zuniga-Pflucker J, Kappes D, Wiest D
    J Exp Med, 2014-02-03;211(2):329-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Dendritic cells activated by double-stranded RNA induce arthritis via autocrine type I IFN signaling.
    Authors: Narendra S, Chalise J, Hook N, Magnusson M
    J Leukoc Biol, 2013-12-04;95(4):661-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.
    Authors: Gao, Xin, Johnson, Kirby D, Chang, Yuan-I, Boyer, Meghan E, Dewey, Colin N, Zhang, Jing, Bresnick, Emery H
    J Exp Med, 2013-12-02;210(13):2833-42.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  73. Identification of transcription factors for lineage-specific ESC differentiation.
    Authors: Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M
    Stem Cell Reports, 2013-11-27;1(6):545-59.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Induction of a hemogenic program in mouse fibroblasts.
    Authors: Pereira C, Chang B, Qiu J, Niu X, Papatsenko D, Hendry C, Clark N, Nomura-Kitabayashi A, Kovacic J, Ma'ayan A, Schaniel C, Lemischka I, Moore K
    Cell Stem Cell, 2013-06-13;13(2):205-18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat.
    Authors: Manley, Nathan C, Caso, Javier R, Works, Melissa, Cutler, Andrew B, Zemlyak, Ilona, Sun, Guohua, Munhoz, Carolina, Chang, Sydney, Sorrells, Shawn F, Ermini, Florian, Decker, Johannes, Bertrand, Anthony, Dinkel, Klaus M, Steinberg, Gary K, Sapolsky, Robert M
    PLoS ONE, 2013-04-16;8(4):e61789.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  76. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells.
    Authors: Gatto D, Wood K, Caminschi I, Murphy-Durland D, Schofield P, Christ D, Karupiah G, Brink R
    Nat Immunol, 2013-03-17;14(5):446-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Synergistic induction of interferon alpha through TLR-3 and TLR-9 agonists identifies CD21 as interferon alpha receptor for the B cell response.
    Authors: Kim D, Niewiesk S
    PLoS Pathog, 2013-03-14;9(3):e1003233.
    Species: Cotton Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  78. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
    Authors: Smith, Christop, Berry, Donna M, McGlade, C Jane
    J Cell Sci, 2013-02-15;126(0):1366-80.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice.
    Authors: Iborra S, Izquierdo HM, Martinez-Lopez M, Blanco-Menendez N, Reis E Sousa C, Sancho D
    J. Clin. Invest., 2012-04-16;122(5):1628-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
    Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
    Immunity, 2008-07-18;29(1):68-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
    Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
    Eur. J. Immunol., 2007-10-01;37(10):2695-706.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
    Authors: Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
    Stem Cells, 2007-02-01;25(2):490-9.
    Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling.
    Authors: Kared H, Adle-Biassette H, Fois E, Masson A, Bach JF, Chatenoud L, Schneider E, Zavala F
    Immunity, 2006-11-02;25(5):823-34.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  84. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
    Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
    Blood, 2006-05-23;108(6):2041-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression.
    Authors: Azhipa O, Kimizuka K, Nakao A, Toyokawa H, Okuda T, Neto JS, Alber SM, Kaizu T, Thomson AW, Demetris AJ, Murase N
    Clin. Immunol., 2005-02-01;114(2):199-209.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  86. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node.
    Authors: Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I
    Proc. Natl. Acad. Sci. U.S.A., 2004-01-13;101(4):998-1003.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  87. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody.
    Authors: Asselin-Paturel C, Brizard G, Pin JJ, Briere F, Trinchieri G
    J. Immunol., 2003-12-15;171(12):6466-77.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Modulation of marrow proliferation and chemosensitivity by tumor-produced cytokines from syngeneic pancreatic tumor lines.
    Authors: Blumenthal RD, Reising A, Leon E
    Clin. Cancer Res., 2002-05-01;8(5):1301-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
    Authors: Shih CC, Hu MC, Hu J
    Blood, 2000-03-15;95(6):1957-66.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Developmet

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