Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF Summary
Product Specifications
Optimal dilutions should be determined by each laboratory for each application.
Mouse ICAM-1 (Gln28-Asn485) Accession # Q3U8M7 |
IEGRMD | Human IgG1 (Pro100-Lys330) |
N-terminus | C-terminus | |
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
796-IC
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution | Reconstitute at 0.4 mg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: ICAM-1/CD54
Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1 beta and LPS. Mouse and human ICAM-1 share approximately 54% amino acid identity.
Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, leukocyte adhesion deficiency syndrome (LAD), cancer and transplantation.
- Pigott, R. and C. Power (1993) in The Adhesion Molecule Facts Book. Academic Press, p. 74.
- Siu, G. et al. (1989) J. Immunol. 143:3813.
- Ballantyne, C.M. et al. (1989) Nuc. Acid. Res. 17:5853.
Citations for Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T�cells with enhanced tumor homing to improve cell therapy
Authors: CP Camargo, AK Muhuri, Y Alapan, LF Sestito, M Khosla, MP Manspeaker, AS Smith, CM Paulos, SN Thomas
Cell Reports, 2023-02-26;42(3):112175.
Species: Mouse
Sample Types: Recombinant Protein
Applications: Bioassay -
TGFbeta1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice
Authors: J Li, Z Yao, X Liu, R Duan, X Yi, A Ayoub, JO Sanders, A Mesfin, L Xing, BF Boyce
Nature Communications, 2023-01-11;14(1):159.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Eph/Ephrin Promotes the Adhesion of Liver Tissue-Resident Macrophages to a Mimicked Surface of Liver Sinusoidal Endothelial Cells
Authors: S Kohara, K Ogawa
Biomedicines, 2022-12-12;10(12):.
Species: Mouse
Sample Types: Tissue Lysate
Applications: Bioassay -
Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis
Authors: S Silva Pere, M De Niz, K Serre, M Ouarné, JE Coelho, CA Franco, LM Figueiredo
Elife, 2022-07-05;11(0):.
Species: Mouse
Sample Types: Recombinant Protein
Applications: Bioassay -
A humanized beta2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in�vivo
Authors: L Wen, A Marki, Z Wang, M Orecchioni, J Makings, M Billitti, E Wang, SSA Suthahar, K Kim, WB Kiosses, Z Mikulski, K Ley
Cell Reports, 2022-05-31;39(9):110876.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome
Authors: Z Ou, E Dolmatova, R Mandavilli, H Qu, G Gafford, T White, A Valdivia, B Lassègue, MS Hernandes, KK Griendling
Journal of the American Heart Association, 2022-05-10;11(10):e025181.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Humanized beta2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation
Authors: T Bromberger, S Klapproth, M Sperandio, M Moser
Cells, 2022-05-03;11(9):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Germinal center expansion but not plasmablast differentiation is proportional to peptide-MHCII density via CD40-CD40L signaling strength
Authors: Z Jing, MJ McCarron, ML Dustin, DR Fooksman
Cell Reports, 2022-05-03;39(5):110763.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Plasma cell dynamics in the bone marrow niche
Authors: Z Benet, Z Jing, DR Fooksman
Cell Reports, 2021-02-09;34(6):108733.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LFA-1 signals to promote actin polymerization and upstream migration in T cells
Authors: NH Roy, SHJ Kim, A Buffone, D Blumenthal, B Huang, S Agarwal, PL Schwartzbe, DA Hammer, JK Burkhardt
J. Cell. Sci., 2020-09-09;133(17):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo
Authors: V Azcutia, M Kelm, AC Luissint, K Boerner, S Flemming, M Quiros, G Newton, A Nusrat, FW Luscinskas, CA Parkos
Mucosal Immunol, 2020-06-19;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cellular locomotion using environmental topography
Authors: A Reversat, F Gaertner, J Merrin, J Stopp, S Tasciyan, J Aguilera, I de Vries, R Hauschild, M Hons, M Piel, A Callan-Jon, R Voituriez, M Sixt
Nature, 2020-05-13;582(7813):582-585.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
CrkL is required for donor T cell migration to GvHD target organs
Authors: NH Roy, M Mammadli, JK Burkhardt, M Karimi
Oncotarget, 2020-04-28;11(17):1505-1514.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
Authors: V Barbier, J Erbani, C Fiveash, JM Davies, J Tay, MR Tallack, J Lowe, JL Magnani, DR Pattabiram, AC Perkins, J Lisle, JEJ Rasko, JP Levesque, IG Winkler
Nat Commun, 2020-04-27;11(1):2042.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cofilin1 driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus
Authors: A Salz, C Gurniak, F Jönsson, W Witke
J. Cell. Sci., 2020-03-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Developing a xenograft model of human vasculature in the mouse ear pinna
Authors: GR Meehan, HE Scales, R Osii, M De Niz, JC Lawton, M Marti, P Garside, A Craig, JM Brewer
Sci Rep, 2020-02-06;10(1):2058.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization
Authors: C Ren, Q Yuan, X Jian, PA Randazzo, W Tang, D Wu
J. Immunol., 2020-01-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival
Authors: GS Gülcüler B, C Monzel, S Kleber, J Beaudouin, E Balta, T Kaindl, S Chen, L Gao, M Thiemann, CR Wirtz, Y Samstag, M Tanaka, A Martin-Vil
Cell Rep, 2019-11-19;29(8):2295-2306.e6.
Species: Mouse
Sample Types: Whole Cell
Applications: Binding Assay -
Increased lymphocyte activation and atherosclerosis in CD47-deficient mice
Authors: D Engelberts, A Autio, RAF Verwillige, MAC Depuydt, G Newton, S Rattik, E Levinsohn, G Saggu, P Jarolim, H Wang, F Velazquez, AH Lichtman, FW Luscinskas
Sci Rep, 2019-07-23;9(1):10608.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Integrin CD11b activation drives anti-tumor innate immunity
Authors: MC Schmid, SQ Khan, MM Kaneda, P Pathria, R Shepard, TL Louis, S Anand, G Woo, C Leem, MH Faridi, T Geraghty, A Rajagopala, S Gupta, M Ahmed, RI Vazquez-Pa, DA Cheresh, V Gupta, JA Varner
Nat Commun, 2018-12-19;9(1):5379.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells
Authors: J Chen, N Li, Y Yin, N Zheng, M Min, B Lin, L Zhang, X Long, Y Zhang, Z Cai, S Zhai, J Qin, X Wang
Cell Rep, 2018-12-18;25(12):3393-3404.e6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Linking single-cell measurements of mass, growth rate, and gene expression
Authors: RJ Kimmerling, SM Prakadan, AJ Gupta, NL Calistri, MM Stevens, S Olcum, N Cermak, RS Drake, K Pelton, F De Smet, KL Ligon, AK Shalek, SR Manalis
Genome Biol., 2018-11-27;19(1):207.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus
Authors: FA Moretti, S Klapproth, R Ruppert, A Margraf, J Weber, R Pick, C Scheierman, M Sperandio, R Fässler, M Moser
Elife, 2018-09-06;7(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive
Authors: M Keszei, J Record, JS Kritikou, H Wurzer, C Geyer, M Thiemann, P Drescher, H Brauner, L Köcher, J James, M He, MA Baptista, CI Dahlberg, A Biswas, S Lain, DP Lane, W Song, K Pütsep, P Vandenberg, SB Snapper, LS Westerberg
J. Clin. Invest., 2018-08-20;128(9):4115-4131.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis
Authors: A Farinazzo, S Angiari, E Turano, E Bistaffa, S Dusi, S Ruggieri, R Bonafede, R Mariotti, G Constantin, B Bonetti
Sci Rep, 2018-05-10;8(1):7473.
Species: Mouse
Sample Types: Complex Sample Type
Applications: Bioassay -
Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion
Authors: M Praetner, G Zuchtriege, M Holzer, B Uhl, J Schaubäche, L Mittmann, M Fabritius, R Fürst, S Zahler, D Funken, M Lerchenber, A Khandoga, S Kanse, K Lauber, F Krombach, CA Reichel
Arterioscler. Thromb. Vasc. Biol., 2018-01-25;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia
Authors: S Paetau, T Rolova, L Ning, CG Gahmberg
Front Mol Neurosci, 2017-12-22;10(0):431.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species
Authors: L Ju, Y Chen, K Li, Z Yuan, B Liu, SP Jackson, C Zhu
Sci Rep, 2017-10-27;7(1):14185.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex
Authors: CP Basole, RK Nguyen, K Lamothe, A Vang, R Clark, GS Baillie, PM Epstein, S Brocke
Cell. Signal., 2017-08-26;40(0):62-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells
Authors: JG Borger, VL Morrison, A Filby, C Garcia, LM Uotila, F Simbari, SC Fagerholm, R Zamoyska
J. Immunol., 2017-06-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells
Authors: S Adutler-Li, I Zaretsky, H Sabany, E Kartvelish, O Golani, B Geiger, N Friedman
Blood Adv, 2017-06-15;1(15):1016-1030.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation
Authors: BR Gittens, JV Bodkin, S Nourshargh, M Perretti, D Cooper
J. Immunol., 2017-04-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis
Authors: Sophia Koutsogian
Toxicol. Sci, 2017-04-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MFG-E8-derived peptide attenuates adhesion and migration of immune cells to endothelial cells
Authors: Y Hirano, WL Yang, M Aziz, F Zhang, B Sherry, P Wang
J. Leukoc. Biol, 2017-01-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Glycogen storage disease type Ib neutrophils exhibit impaired cell adhesion and migration
Authors: Janice Chou
Biochem. Biophys. Res. Commun., 2016-11-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Aged neutrophils contribute to the first line of defense in the acute inflammatory response
Blood, 2016-09-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens
J Leukoc Biol, 2016-09-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice
J Immunol, 2016-08-26;0(0):.
Species: Mouse
Sample Types: Whole Blood
Applications: Bioassay -
Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration
J Immunol, 2016-07-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion
J Immunol, 2016-07-25;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Post-arrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro
Authors: Henriette Rudolph
Eur J Immunol, 2016-07-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
WNK1 kinase balances T cell adhesion versus migration in vivo
Nat Immunol, 2016-07-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice
Eur J Immunol, 2016-06-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Platelets Guide Leukocytes to Their Sites of Extravasation
PLoS Biol, 2016-05-06;14(5):e1002459.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the alpha4beta1-integrin.
Authors: Martin-Blondel G, Pignolet B, Tietz S, Yshii L, Gebauer C, Perinat T, Van Weddingen I, Blatti C, Engelhardt B, Liblau R
Eur J Immunol, 2015-10-06;45(12):3302-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow.
Authors: Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson L, McEver R
J Immunol, 2015-09-09;195(8):3880-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Blocking neutrophil integrin activation prevents ischemia-reperfusion injury.
Authors: Yago T, Petrich B, Zhang N, Liu Z, Shao B, Ginsberg M, McEver R
J Exp Med, 2015-07-13;212(8):1267-81.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.
Authors: Na B, Kim H, Piragyte I, Oh H, Kwon M, Akber U, Lee H, Park D, Song W, Park Z, Im S, Rho M, Hyun Y, Kim M, Jun C
J Cell Biol, 2015-04-13;209(1):143-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Adhesion Assay -
CRK proteins selectively regulate T cell migration into inflamed tissues.
Authors: Huang, Yanping, Clarke, Fiona, Karimi, Mobin, Roy, Nathan H, Williamson, Edward K, Okumura, Mariko, Mochizuki, Kazuhiro, Chen, Emily J, Park, Tae-Ju, Debes, Gudrun F, Zhang, Yi, Curran, Tom, Kambayashi, Taku, Burkhardt, Janis K
J Clin Invest, 2015-01-26;125(3):1019-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation.
Authors: Germena G, Volmering S, Sohlbach C, Zarbock A
J Immunol, 2014-12-10;194(2):728-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
Authors: Kovacs M, Nemeth T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell C, Mocsai A
J Exp Med, 2014-09-15;211(10):1993-2011.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD45 ligation expands Tregs by promoting interactions with DCs.
Authors: Camirand, Geoffrey, Wang, Ying, Lu, Yuning, Wan, Yisong Y, Lin, Yan, Deng, Songyan, Guz, Galip, Perkins, David L, Finn, Patricia, Farber, Donna L, Flavell, Richard, Shlomchik, Warren D, Lakkis, Fadi G, Rudd, Christop, Rothstein, David M
J Clin Invest, 2014-09-09;124(10):4603-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.
Authors: Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J
J Exp Med, 2014-09-01;211(10):1957-68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.
Authors: Xu, Xiaolu, Jaeger, Emily R, Wang, Xinxin, Lagler-Ferrez, Erica, Batalov, Serge, Mathis, Nancy L, Wiltshire, Tim, Walker, John R, Cooke, Michael, Sauer, Karsten, Huang, Yina H
PLoS ONE, 2014-08-18;9(8):e105561.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cytoskeletal regulatory gene expression and migratory properties of B-cell progenitors are affected by the ETV6-RUNX1 rearrangement.
Authors: Palmi C, Fazio G, Savino A, Procter J, Howell L, Cazzaniga V, Vieri M, Longinotti G, Brunati I, Andre V, Della Mina P, Villa A, Greaves M, Biondi A, D'Amico G, Ford A, Cazzaniga G
Mol Cancer Res, 2014-07-24;12(12):1796-806.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of T cell motility in vitro and in vivo by LPA and LPA2.
Authors: Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, Georas S
PLoS ONE, 2014-07-08;9(7):e101655.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis.
Authors: Gobel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth S
Eur J Immunol, 2014-06-05;44(8):2295-305.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness.
Authors: Wang X, Rodda L, Bannard O, Cyster J
J Immunol, 2014-04-16;192(10):4601-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays.
Authors: Jung H, Song K, Chang J, Doh J
PLoS ONE, 2014-03-14;9(3):e91926.
Applications: Bioassay -
Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
Authors: Jenkins, Misty R, Stinchcombe, Jane C, Au-Yeung, Byron B, Asano, Yukako, Ritter, Alex T, Weiss, Arthur, Griffiths, Gillian
Elife, 2014-03-04;3(0):e01310.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
alphaPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.
Authors: Korthals M, Schilling K, Reichardt P, Mamula D, Schluter T, Steiner M, Langnase K, Thomas U, Gundelfinger E, Premont R, Tedford K, Fischer K
J Immunol, 2014-03-03;192(7):3228-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function.
Authors: Foley M, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker B, Irvine D
PLoS ONE, 2014-02-13;9(2):e87873.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11/CD18).
Authors: Weckbach L, Gola A, Winkelmann M, Jakob S, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Muller-Hocker J, Deindl E, Sperandio M, Walzog B
Blood, 2014-01-23;123(12):1887-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein.
Authors: Bosticardo, Marita, Musio, Silvia, Fontana, Elena, Angiari, Stefano, Draghici, Elena, Constantin, Gabriela, Poliani, Pietro L, Pedotti, Rosetta, Villa, Anna
PLoS ONE, 2014-01-23;9(1):e86942.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis.
Authors: Dalli, Jesmond, Norling, Lucy V, Montero-Melendez, Trinidad, Federici Canova, Donata, Lashin, Hazem, Pavlov, Anton M, Sukhorukov, Gleb B, Hinds, Charles, Perretti, Mauro
EMBO Mol Med, 2013-12-15;6(1):27-42.
Species: Mouse
Sample Types: Plasma
Applications: Bioassay -
A circadian clock gene, Rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
Authors: Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T
J Immunol, 2013-12-04;192(1):407-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.
Authors: Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K
PLoS ONE, 2013-11-18;8(11):e80500.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
PKCtheta regulates T cell motility via ezrin-radixin-moesin localization to the uropod.
Authors: Cannon J, Asperti-Boursin F, Letendre K, Brown I, Korzekwa K, Blaine K, Oruganti S, Sperling A, Moses M
PLoS ONE, 2013-11-08;8(11):e78940.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis.
Authors: Schmitt, Martin M, Megens, Remco T, Zernecke, Alma, Bidzhekov, Kiril, van den Akker, Nynke M, Rademakers, Timo, van Zandvoort, Marc A, Hackeng, Tilman M, Koenen, Rory R, Weber, Christia
Circulation, 2013-09-24;129(1):66-76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naive T-cell homing.
Authors: Perez-Rivero G, Cascio G, Soriano S, Sanz A, de Guinoa J, Rodriguez-Frade J, Gomariz R, Holgado B, Cabanas C, Carrasco Y, Stein J, Mellado M
Eur J Immunol, 2013-05-17;43(7):1745-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation.
Authors: Giegold O, Ogrissek N, Richter C, Schroder M, Herrero San Juan M, Pfeilschifter J, Radeke H
J Immunol, 2013-02-27;190(7):3696-705.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells.
Authors: Marangoni F, Murooka T, Manzo T, Kim E, Carrizosa E, Elpek N, Mempel T
Immunity, 2013-01-11;38(2):237-49.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.
Authors: Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y
J Biol Chem, 2012-09-27;287(46):39041-9.
Applications: Surface Plasmon Resonance -
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.
Authors: Hyun YM, Sumagin R, Sarangi PP
J. Exp. Med., 2012-06-18;209(7):1349-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-beta signaling.
Authors: Verma N, Dempsey E, Long A, Davies A, Barry S, Fallon P, Volkov Y, Kelleher D
J Biol Chem, 2012-06-15;287(32):27204-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
Authors: Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH
J. Immunol., 2012-01-04;188(3):1421-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-12 enhances CTL synapse formation and induces self-reactivity.
Authors: Markiewicz MA, Wise EL, Buchwald ZS, Cheney EE, Hansen TH, Suri A, Cemerski S, Allen PM, Shaw AS
J. Immunol., 2009-02-01;182(3):1351-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.
Authors: Park EJ, Mora JR, Carman CV, Chen J, Sasaki Y, Cheng G, von Andrian UH, Shimaoka M
J. Clin. Invest., 2007-09-01;117(9):2526-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
Authors: Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R
J. Leukoc. Biol., 2006-12-18;81(3):748-56.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells.
Authors: Bate C, Kempster S, Williams A
Neuropharmacology, 2005-11-11;50(2):229-37.
Species: Mouse
Sample Types: Whole Cells
Applications: Control
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