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Recombinant Mouse IL-1 beta/IL-1F2 Protein

Catalog #: 401-ML
256 Citations 7 Reviews Datasheet / COA / SDS

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401-ML-005/CF
401-ML-025/CF
401-ML-010/CF
401-ML-100/CF

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401-ML-005
401-ML-025
401-ML-010
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Recombinant Mouse IL-1 beta/IL-1F2 Protein Bioactivity
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Product Details
Citations (256)
FAQs
Reviews (7)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse IL-1 beta/IL-1F2 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED50 for this effect is 2-10 pg/mL.
Source
E. coli-derived mouse IL-1 beta/IL-1F2 protein
Val118-Ser269, with an N-terminal Met
Accession #
NP_032387
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
17 kDa

Product Datasheets

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401-ML (with carrier)

Product Datasheet
COA
SDS

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401-ML/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

401-ML

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

401-ML/CF

Formulation Supplied as a 0.2 μm filtered solution in PBS.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Supplied as a 0.2 μm filtered solution in PBS.

Scientific Data

Bioactivity Recombinant Mouse IL-1 beta/IL-1F2 Protein Bioactivity View Larger

Recombinant Mouse IL-1 beta /IL-1F2 (Catalog # 401-ML) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is 2‑10 pg/mL.

SDS-PAGE Recombinant Mouse IL-1 beta/IL-1F2 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse IL1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-1 beta/IL-1F2

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The mouse IL-1 beta cDNA encodes a 269 aa precursor. A 117 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5, 6). The 17 kDa mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 65%-78% identity with canine, equine, feline, human, porcine, and rhesus IL-1 beta.

References
  1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.
  2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
  3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.
  4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.
  5. Gray, P.W. et al. (1986) J. Immunol. 137:3644.
  6. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.
Long Name
Interleukin 1 beta
Entrez Gene IDs
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
Alternate Names
catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta

Citations for Recombinant Mouse IL-1 beta/IL-1F2 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

256 Citations: Showing 1 - 10
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  1. Stevioside protects primary articular chondrocytes against IL-1?-induced inflammation and catabolism by targeting integrin
    Authors: Wan, J;Zhu, Z;He, Z;Wu, H;Chen, A;Zhu, W;Cheng, P;
    International immunopharmacology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages
    Authors: Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D;
    Journal of translational medicine
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis
    Authors: Wayne, CR;Bremner, L;Faust, TE;Dur�n-Laforet, V;Ampatey, N;Ho, SJ;Feinberg, PA;Arvanitis, P;Ciric, B;Ruan, C;Elyaman, W;Delaney, SL;Vargas, WS;Swedo, S;Menon, V;Schafer, DP;Cutforth, T;Agalliu, D;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Inhibition of Histone Lysine Demethylase 6A Promotes Chondrocytic Activity and Attenuates Osteoarthritis Development through Repressing H3K27me3 Enhancement of Wnt10a
    Authors: WS Lian, RW Wu, JY Ko, YS Chen, SY Wang, H Jahr, FS Wang
    The international journal of biochemistry & cell biology, 2023-03-05;0(0):106394.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge
    Authors: CM Schafer, S Martin-Alm, K Kurylowicz, N Dufton, L Osuna-Alma, ML Wu, CF Johnson, AV Shah, DO Haskard, A Buxton, E Willis, K Wheeler, S Turner, M Chlebicz, RP Scott, S Kovats, A Cleuren, GM Birdsey, AM Randi, CT Griffin
    bioRxiv : the preprint server for biology, 2023-02-11;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  6. Modulation of Skin Inflammatory Responses by Aluminum Adjuvant
    Authors: Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang
    Pharmaceutics, 2023-02-08;15(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Crosstalk between ILC2s and Th2 cells varies among mouse models
    Authors: RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu
    Cell Reports, 2023-02-02;42(2):112073.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha
    Authors: PA Dumesic, SE Wilensky, S Bose, JG Van Vranke, SP Gygi, BM Spiegelman
    bioRxiv : the preprint server for biology, 2023-01-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1alpha signaling and glutamine metabolism
    Authors: G Wang, E Sweren, W Andrews, Y Li, J Chen, Y Xue, E Wier, MP Alphonse, L Luo, Y Miao, R Chen, D Zeng, S Lee, A Li, E Dare, D Kim, NK Archer, SK Reddy, L Resar, Z Hu, EA Grice, MA Kane, LA Garza
    Science Advances, 2023-01-04;9(1):eabo7555.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Identification of astrocyte regulators by nucleic acid cytometry
    Authors: IC Clark, MA Wheeler, HG Lee, Z Li, LM Sanmarco, S Thaploo, CM Polonio, SW Shin, G Scalisi, AR Henry, JM Rone, F Giovannoni, M Charabati, CF Akl, DM Aleman, SEJ Zandee, A Prat, DC Douek, EA Boritz, FJ Quintana, AR Abate
    Nature, 2023-01-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
    Authors: S Zia, BP Hammond, M Zirngibl, A Sizov, CS Baaklini, SP Panda, MFS Ho, KV Lee, A Mainali, MK Burr, S Williams, AV Caprariell, C Power, T Simmen, BJ Kerr, JR Plemel
    Molecular Neurodegeneration, 2022-12-13;17(1):82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis
    Authors: HZ Yu, BQ Zhu, L Zhu, S Li, LM Wang
    Oncogene, 2022-12-01;17(12):2765-2770.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Zinc Transporter 8 Haploinsufficiency Protects Against Beta Cell Dysfunction in Type 1 Diabetes by Increasing Mitochondrial Respiration
    Authors: YK Kim, JA Walters, ND Moss, KL Wells, R Sheridan, JG Miranda, RKP Benninger, LL Pyle, RM O'Brien, L Sussel, HW Davidson
    Molecular Metabolism, 2022-11-05;66(0):101632.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  14. Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity
    Authors: AG Yates, E Kislitsyna, C Alfonso Ma, J Zhang, AL Sewell, A Goikolea-V, V Cai, LF Alkhader, A Skaland, B Hammond, R Dimitrova, D Batalle, C Fernandes, AD Edwards, P Gressens, C Thornton, HB Stolp
    Journal of Neuroinflammation, 2022-10-29;19(1):265.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. Desmoglein-2 is important for islet function and beta-cell survival
    Authors: KK Myo Min, D Rojas-Cana, D Penko, M DeNichilo, MP Cockshell, CB Ffrench, EJ Thompson, O Asplund, CJ Drogemulle, RB Prasad, L Groop, ST Grey, HE Thomas, T Loudovaris, TW Kay, MG Mahoney, CF Jessup, PT Coates, CS Bonder
    Cell Death & Disease, 2022-10-29;13(10):911.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
    Authors: A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe
    Nature, 2022-10-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. IL-3 regulates the differentiation of pathogenic Th17 cells
    Authors: L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani
    European Journal of Immunology, 2022-09-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Bioassay
  18. A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury
    Authors: C Navarrete, A García-Mar, A Correa-Sáe, ME Prados, F Fernández, R Pineda, M Mazzone, M Álvarez-Be, MA Calzado, E Muñoz
    Journal of Neuroinflammation, 2022-07-09;19(1):177.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32
    Authors: J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu, Z Yao, L Liu, H Zhang, B Luo, X Wang, C Zeng, X Bai, H Zhang, D Cai
    Cell Death & Disease, 2022-06-24;13(6):567.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement
    Authors: H Kamei, T Ishii, Y Nishii
    Oncogene, 2022-06-02;12(1):9243.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Brain Protective Effect of Resveratrol via Ameliorating Interleukin-1beta-Induced MMP-9-Mediated Disruption of ZO-1 Arranged Integrity
    Authors: MM Tsai, JL Chen, TH Lee, H Liu, V Shanmugam, HL Hsieh
    Biomedicines, 2022-05-29;10(6):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
    Authors: LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh
    Cell Reports, 2022-05-24;39(8):110838.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
    Authors: HW Cheng, U Mörbe, M Lütge, C Engetschwi, L Onder, M Novkovic, C Gil-Cruz, C Perez-Shib, T Hehlgans, E Scandella, B Ludewig
    Nature Communications, 2022-04-19;13(1):2027.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65
    Authors: H Jiang, X Lin, W Liang, Y Li, X Yu
    Nutrients, 2022-04-18;14(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival
    Authors: N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber
    Cell Reports, 2022-03-29;38(13):110565.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. RORgammat phosphorylation protects against T�cell-mediated inflammation
    Authors: S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang
    Cell Reports, 2022-03-15;38(11):110520.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  27. Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway
    Authors: Z Guo, J Lin, K Sun, J Guo, X Yao, G Wang, L Hou, J Xu, J Guo, F Guo
    Frontiers in Pharmacology, 2022-03-14;13(0):791376.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Ferroptosis as a Novel Determinant of beta-Cell Death in Diabetic Conditions
    Authors: A Stancic, T Saksida, M Markelic, M Vucetic, I Grigorov, V Martinovic, D Gajic, A Ivanovic, K Velickovic, N Savic, V Otasevic
    Oxidative Medicine and Cellular Longevity, 2022-03-14;2022(0):3873420.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  29. SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis
    Authors: CK Cheng, X Lin, Y Pu, JKY Tse, Y Wang, CL Zhang, X Cao, CW Lau, J Huang, L He, JY Luo, YT Shih, S Wan, CF Ng, L Wang, RCW Ma, JJ Chiu, TF Chan, X Yu Tian, Y Huang
    Journal of advanced research, 2022-03-01;43(0):187-203.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Organ Culture
  30. Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2
    Authors: AS Wilson, KL Randall, JA Pettitt, JI Ellyard, A Blumenthal, A Enders, BJ Quah, T Bopp, CR Parish, A Brüstle
    Nature Communications, 2022-01-26;13(1):528.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Dynamic changes in beta-cell [Ca2+] regulates NFAT activation, gene transcription and islet gap junction communication
    Authors: JG Miranda, WE Schleicher, KL Wells, DG Ramirez, SP Landgrave, RK Benninger
    Oncogene, 2021-12-31;0(0):101430.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Pericytes as mediators of infiltration of macrophages in multiple sclerosis
    Authors: DK Kaushik, A Bhattachar, BM Lozinski, V Wee Yong
    Journal of Neuroinflammation, 2021-12-24;18(1):301.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease
    Authors: Y Duan, H Chu, K Brandl, L Jiang, S Zeng, N Meshgin, E Papachrist, J Argemi, BG Mendes, Y Wang, H Su, W Sun, C Llorente, T Hendrikx, X Liu, M Hosseini, T Kisseleva, DA Brenner, R Bataller, P Ramachandr, M Karin, W Fu, B Schnabl
    Nature Communications, 2021-12-09;12(1):7172.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets
    Authors: A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial
    Cell Reports, 2021-11-23;37(8):110037.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  35. Differential Cytokine-Induced Responses of Polarized Microglia
    Authors: P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard
    Brain sciences, 2021-11-10;11(11):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons
    Authors: Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu
    Journal of Neuroinflammation, 2021-11-08;18(1):261.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2
    Authors: C van de Wet, AM Manuel, M Sharafi, R Aboushoush, X Qian, C Erickson, M MacPherson, G Chan, IM Adcock, N ZounematKe, F Schleich, R Louis, E Bohrnsen, A D'Alessand, EF Wouters, NL Reynaert, J Li, CR Wolf, CJ Henderson, LKA Lundblad, ME Poynter, AE Dixon, CG Irvin, A van der Vl, JL van der Ve, YM Janssen-He
    Redox Biology, 2021-10-03;47(0):102160.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  38. Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes
    Authors: S Lee, A Ishitsuka, T Kuroki, YH Lin, A Shibuya, T Hongu, Y Funakoshi, Y Kanaho, K Nagata, A Kawaguchi
    JCI Insight, 2021-08-23;6(16):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  39. Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice
    Authors: M Han, T Ishikawa, CC Stroupe, HA Breckenrid, JK Bentley, MB Hershenson
    Mucosal Immunology, 2021-08-05;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  40. Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal &gamma&delta T�cells
    Authors: L Dupraz, A Magniez, N Rolhion, ML Richard, G Da Costa, S Touch, C Mayeur, J Planchais, A Agus, C Danne, C Michaudel, M Spatz, F Trottein, P Langella, H Sokol, ML Michel
    Cell Reports, 2021-07-06;36(1):109332.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Ontogenic timing, T�cell receptor signal strength, and Notch signaling direct &gamma&delta T�cell functional differentiation in�vivo
    Authors: ELY Chen, CR Lee, PK Thompson, DL Wiest, MK Anderson, JC Zúñiga-Pfl
    Cell Reports, 2021-06-08;35(10):109227.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells
    Authors: A Singh, M Dashynam, B Chim, TM Escobar, X Liu, X Hu, S Patnaik, X Xu, N Southall, J Marugan, A Jadhav, V Lazarevic, SA Muljo, M Ferrer
    Scientific Reports, 2021-06-01;11(1):11498.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes
    Authors: FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos
    Cell Reports, 2021-05-25;35(8):109176.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients
    Authors: V Farré-Alin, A Palomino-A, P Narros-Fer, AB Lopez-Rodr, C Decouty-Pe, A Muñoz-Mont, J Zamorano-F, B Mansilla-F, J Giner-Garc, P García-Fei, M Sáez-Alegr, AJ Palpán-Flo, JM Roda-Frade, CS Carabias, JM Rosa, B Civantos-M, S Yus-Teruel, L Gandía, A Lagares, BJ Hernández-, J Egea
    Biomedicines, 2021-05-25;9(6):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-&kappaB pathway
    Authors: Y Lu, L Liu, J Pan, B Luo, H Zeng, Y Shao, H Zhang, H Guan, D Guo, C Zeng, R Zhang, X Bai, H Zhang, D Cai
    Cell Death & Disease, 2021-05-25;12(6):533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  46. Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
    Authors: X Han, T Xu, Q Fang, H Zhang, L Yue, G Hu, L Sun
    Redox Biology, 2021-05-25;44(0):102010.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  47. TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
    Authors: J Zhao, B Cai, Z Shao, L Zhang, Y Zheng, C Ma, F Yi, B Liu, C Gao
    Cell Death and Differentiation, 2021-05-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
    Authors: R Grieshaber, FA Radtke, P Cunin, G Stifano, A Levescot, B Vijaykumar, N Nelson-Man, RB Blaustein, PA Monach, PA Nigrovic, ImmGen Con
    Nature Communications, 2021-05-17;12(1):2856.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  49. Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1&beta Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation
    Authors: DW Kwak, D Park, JH Kim
    Biomedicines, 2021-05-11;9(5):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Neuromodulatory effect of interleukin 1&beta in the dorsal raphe nucleus on individual differences in aggression
    Authors: A Takahashi, H Aleyasin, MA Stavarache, L Li, F Cathomas, LF Parise, HY Lin, CJ Burnett, A Aubry, ME Flanigan, A Brancato, C Menard, ML Pfau, V Kana, J Wang, GE Hodes, T Sasaki, MG Kaplitt, S Ogawa, BS McEwen, SJ Russo
    Molecular Psychiatry, 2021-04-30;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  51. Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level
    Authors: HR Clark, C McKenney, NM Livingston, A Gershman, S Sajjan, IS Chan, AJ Ewald, W Timp, B Wu, A Singh, S Regot
    Nature Communications, 2021-03-23;12(1):1836.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. N4BP1 negatively regulates NF-&kappaB by binding and inhibiting NEMO oligomerization
    Authors: H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler
    Nature Communications, 2021-03-02;12(1):1379.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress
    Authors: M Ichii, K Oritani, J Toda, H Saito, H Shi, H Shibayama, D Motooka, Y Kitai, R Muromoto, JI Kashiwakur, K Saitoh, D Okuzaki, T Matsuda, Y Kanakura
    Haematologica, 2021-02-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Cell Culture
  54. Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice
    Authors: L Micheli, M Vasarri, E Barletta, E Lucarini, C Ghelardini, D Degl'Innoc, L Di Cesare
    Marine Drugs, 2021-01-21;19(2):.
    Species: Mouse
    Sample Types: In Vitro
    Applications: Bioassay
  55. Gut-licensed IFN&gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
    Authors: LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana
    Nature, 2021-01-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress
    Authors: Y Yang, P Shen, T Yao, J Ma, Z Chen, J Zhu, Z Gong, S Shen, X Fang
    Theranostics, 2021-01-01;11(4):1877-1900.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Airway-Associated Macrophages in Homeostasis and Repair
    Authors: AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock
    Cell Reports, 2020-12-29;33(13):108553.
    Species: Transgenic Mouse
    Sample Types: Spheroid
    Applications: Bioassay
  58. Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models
    Authors: E Nummenmaa, M Hämäläinen, A Pemmari, LJ Moilanen, L Tuure, RM Nieminen, T Moilanen, K Vuolteenah, E Moilanen
    International Journal of Molecular Sciences, 2020-12-23;22(1):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Cell Culture, Tissue Culture
  59. Chondrocyte ferroptosis contribute to the progression of osteoarthritis
    Authors: X Yao, K Sun, S Yu, J Luo, J Guo, J Lin, G Wang, Z Guo, Y Ye, F Guo
    Journal of Orthopaedic Translation, 2020-12-17;27(0):33-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  60. Heparan sulfate functions are altered in the osteoarthritic cartilage
    Authors: S Shamdani, S Chantepie, C Flageollet, N Henni-Cheb, Y Jouan, F Eymard, E Hay, M Cohen-Sola, D Papy-Garci, X Chevalier, P Albanese
    Arthritis Research & Therapy, 2020-12-07;22(1):283.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  61. EBV-induced gene 3 augments IL-23R&alpha protein expression through a chaperone calnexin
    Authors: I Mizoguchi, M Ohashi, H Hasegawa, Y Chiba, N Orii, S Inoue, C Kawana, M Xu, K Sudo, K Fujita, M Kuroda, SI Hashimoto, K Matsushima, T Yoshimoto
    J. Clin. Invest., 2020-11-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
    Authors: S Lee, S Kim, HY Kang, HR Lim, Y Kwon, M Jo, YM Jeon, SR Kim, K Kim, CM Ha, S Lee, HJ Kim
    J Neuroinflammation, 2020-10-14;17(1):299.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Bioassay
  63. Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
    Authors: F Namai, S Shigemori, T Ogita, T Sato, T Shimosato
    Exp Mol Med, 2020-09-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation
    Authors: V Grubiši?, JL McClain, DE Fried, I Grants, P Rajasekhar, E Csizmadia, OA Ajijola, RE Watson, DP Poole, SC Robson, FL Christofi, BD Gulbransen
    Cell Rep, 2020-09-08;32(10):108100.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation
    Authors: MA Maqbool, L Pioger, AZ El Aabidin, N Karasu, AM Molitor, LTM Dao, G Charbonnie, F van Laethe, R Fenouil, F Koch, G Lacaud, I Gut, M Gut, S Amigorena, O Joffre, T Sexton, S Spicuglia, JC Andrau
    Cell Rep, 2020-08-18;32(7):108048.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  66. Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells
    Authors: J Jhun, HK Min, J Ryu, SY Lee, JG Ryu, JW Choi, HS Na, SY Lee, Y Jung, SJ Park, MS Park, B Kwon, GE Ji, ML Cho, SH Park
    J Transl Med, 2020-08-15;18(1):317.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  67. The methylation status of the chemerin promoter region located from -?252 to +?258�bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels
    Authors: K Kwiecien, P Brzoza, M Bak, P Majewski, I Skulimowsk, K Bednarczyk, J Cichy, M Kwitniewsk
    Sci Rep, 2020-08-13;10(1):13702.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay, In Vivo
  68. Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis
    Authors: M Liu, M Yan, H Lv, B Wang, X Lv, H Zhang, S Xiang, J Du, T Liu, Y Tian, X Zhang, F Zhou, T Cheng, Y Zhu, H Jiang, Y Cao, D Ai
    Cell Rep, 2020-08-04;32(5):107990.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury
    Authors: H Ito, H Kimura, T Karasawa, S Hisata, A Sadatomo, Y Inoue, N Yamada, E Aizawa, E Hishida, R Kamata, T Komada, S Watanabe, T Kasahara, T Suzuki, H Horie, J Kitayama, N Sata, K Yamaji-Keg, M Takahashi
    J. Immunol., 2020-07-29;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot Control
  70. The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain
    Authors: T Osthues, B Zimmer, V Rimola, K Klann, K Schilling, P Mathoor, C Angioni, A Weigert, G Geisslinge, C Münch, K Scholich, M Sisignano
    Cells, 2020-07-21;9(7):.
    Species: Mouse
    Sample Types: Cell Culture Lysates
    Applications: Bioassay
  71. Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
    Authors: Y Dong, S Li, Y Lu, X Li, Y Liao, Z Peng, Y Li, L Hou, Z Yuan, J Cheng
    J Neuroinflammation, 2020-07-07;17(1):205.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
    Authors: J Kealy, C Murray, EW Griffin, AB Lopez-Rodr, D Healy, LS Tortorelli, JP Lowry, LO Watne, C Cunningham
    J. Neurosci., 2020-06-08;0(0):.
    Species: Mouse, Transgenic Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  73. gammadelta T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis
    Authors: L Monin, DS Ushakov, H Arnesen, N Bah, A Jandke, M Muñoz-Ruiz, J Carvalho, S Joseph, BC Almeida, MJ Green, E Nye, S Hatano, Y Yoshikai, M Curtis, H Carlsen, U Steinhoff, P Boysen, A Hayday
    Mucosal Immunol, 2020-05-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Paracrine regulation and improvement of &beta-cell function by thioredoxin
    Authors: EM Hanschmann, SF Petry, S Eitner, CC Maresch, N Lingwal, CH Lillig, T Linn
    Redox Biol, 2020-05-16;34(0):101570.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  75. Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype
    Authors: B Hou, Y Zhang, P Liang, Y He, B Peng, W Liu, S Han, J Yin, X He
    Cell Death Dis, 2020-05-15;11(5):377.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
    Authors: Y Huang, H Wang, Y Hao, H Lin, M Dong, J Ye, L Song, Y Wang, Q Li, B Shan, Y Jiang, H Li, Z Shao, G Kroemer, H Zhang, L Bai, T Jin, C Wang, Y Ma, Y Cai, C Ding, S Liu, Y Pan, W Jiang, R Zhou
    Nat. Cell Biol., 2020-05-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1
    Authors: S Ma, A Zhang, X Li, S Zhang, S Liu, H Zhao, S Wu, L Chen, C Ma, H Zhao
    Arthritis Res. Ther., 2020-05-01;22(1):99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Noggin Inhibits IL-1&beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis
    Authors: SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin, YZ Yang, CH Tang
    Cells, 2020-04-10;9(4):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  79. Expression and Role of IL-1&beta Signaling in Chondrocytes Associated with Retinoid Signaling during Fracture Healing
    Authors: T Shimo, H Takebe, T Okui, Y Kunisada, S Ibaragi, K Obata, N Kurio, K Shamsoon, S Fujii, A Hosoya, K Irie, A Sasaki, M Iwamoto
    Int J Mol Sci, 2020-03-29;21(7):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts
    Authors: O Haidar, N O'Neill, CA Staunton, S Bavan, F O'Brien, S Zouggari, U Sharif, A Mobasheri, K Kumagai, R Barrett-Jo
    Front Physiol, 2020-03-24;11(0):226.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Bioassay
  81. Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior
    Authors: H Li, X Ding, R Terkeltaub, H Lin, Y Zhang, B Zhou, K He, K Li, Z Liu, J Wei, Y Yang, H Xie, C Zeng, G Lei
    Arthritis Res. Ther., 2020-02-22;22(1):34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  82. MAFG-driven astrocytes promote CNS inflammation
    Authors: MA Wheeler, IC Clark, EC Tjon, Z Li, SEJ Zandee, CP Couturier, BR Watson, G Scalisi, S Alkwai, V Rothhammer, A Rotem, JA Heyman, S Thaploo, LM Sanmarco, J Ragoussis, DA Weitz, K Petrecca, JR Moffitt, B Becher, JP Antel, A Prat, FJ Quintana
    Nature, 2020-02-12;0(0):.
    Species: Mouse
    Sample Types: Cells
    Applications: Cell Culture
  83. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
    Authors: FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley
    Nat Commun, 2020-01-30;11(1):600.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1&beta Production
    Authors: JH Jang, DH Kim, JM Lim, JW Lee, SJ Jeong, KP Kim, YJ Surh
    Cancer Res, 2020-01-22;80(6):1342-1356.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  85. Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease
    Authors: C van de Wet, R Aboushoush, AM Manuel, SB Chia, C Erickson, MB MacPherson, JL van der Ve, V Anathy, AE Dixon, CG Irvin, ME Poynter, A van der Vl, EFM Wouters, NL Reynaert, YMW Janssen-He
    J. Immunol., 2020-01-10;204(4):763-774.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Cell Culture, In Vivo
  86. Dengue Virus Infection Activates Interleukin-1beta to Induce Tissue Injury and Vascular Leakage
    Authors: P Pan, Q Zhang, W Liu, W Wang, Z Yu, Z Lao, W Zhang, M Shen, P Wan, F Xiao, MA Shereen, W Zhang, Q Tan, Y Liu, X Liu, K Wu, Y Liu, G Li, J Wu
    Front Microbiol, 2019-11-22;10(0):2637.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  87. Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 &beta expression
    Authors: HS Son, J Lee, HI Lee, N Kim, YJ Jo, GR Lee, SE Hong, M Kwon, NY Kim, HJ Kim, JH Park, SY Lee, W Jeong
    Acta Pharm Sin B, 2019-11-08;10(3):462-474.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  88. A20 as an immune tolerance factor can determine islet transplant outcomes
    Authors: NW Zammit, SN Walters, KL Seeberger, PJ O'Connell, GS Korbutt, ST Grey
    JCI Insight, 2019-11-01;4(21):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
    Authors: D Pham, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun, BL Kee, RM Myers, CT Weaver, RD Hatton
    Cell Rep, 2019-10-29;29(5):1203-1220.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
    Authors: S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet
    Nature, 2019-10-23;574(7779):553-558.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  91. NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17
    Authors: HG Lee, LK Kim, JM Choi
    Mol Ther Methods Clin Dev, 2019-10-23;16(0):32-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  92. Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra
    Authors: DX Ji, LH Yamashiro, KJ Chen, N Mukaida, I Kramnik, KH Darwin, RE Vance
    Nat Microbiol, 2019-10-14;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Bioassay
  93. Serum amyloid A-mediated inflammasome activation of microglial cells in cerebral ischemia
    Authors: J Yu, H Zhu, S Taheri, W Mondy, L Bonilha, GS Magwood, D Lackland, RJ Adams, MS Kindy
    J. Neurosci., 2019-10-14;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  94. Phlda3 regulates beta cell survival during stress
    Authors: M Bensellam, JY Chan, K Lee, MV Joglekar, AA Hardikar, T Loudovaris, HE Thomas, JC Jonas, DR Laybutt
    Sci Rep, 2019-09-06;9(1):12827.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Increased ILC3s associated with higher levels of IL-1? aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase
    Authors: TY Chan, CL Yen, YF Huang, PC Lo, PA Nigrovic, CY Cheng, WZ Wang, SY Wu, CC Shieh
    Eur. J. Immunol., 2019-08-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  96. Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis
    Authors: S Darkwah, N Nago, MG Appiah, PK Myint, E Kawamoto, M Shimaoka, EJ Park
    Biomedicines, 2019-07-18;7(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Interleukin-1? Promotes Schwann Cells De-Differentiation in Wallerian Degeneration via the c-JUN/AP-1 Pathway
    Authors: G Chen, X Luo, W Wang, Y Wang, F Zhu, W Wang
    Front Cell Neurosci, 2019-07-09;13(0):304.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Tissue Culture
  98. 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt
    Authors: C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai
    Bioorg. Chem., 2019-06-21;90(0):103077.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  99. Reactive microglia and IL1?/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
    Authors: L Todd, I Palazzo, L Suarez, X Liu, L Volkov, TV Hoang, WA Campbell, S Blackshaw, N Quan, AJ Fischer
    J Neuroinflammation, 2019-06-06;16(1):118.
    Species: Mouse, Transgenic Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  100. NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death
    Authors: K Radulovic, CK Ayata, R Mak'Anyeng, K Lechner, P Wuggenig, B Kaya, P Hruz, M Gomez de A, P Broz, B Weigmann, JH Niess
    J. Immunol., 2019-05-31;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. 3?-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation
    Authors: X Zhou, H Chen, F Wei, Q Zhao, Q Su, J Liang, M Yin, X Tian, Z Liu, B Yu, C Bai, X He, Z Huang
    J Immunol Res, 2019-05-22;2019(0):2431617.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  102. ? Cell Hypoxia-Inducible Factor-1? Is Required for the Prevention of Type 1 Diabetes
    Authors: A Lalwani, J Warren, D Liuwantara, WJ Hawthorne, PJ O'Connell, FJ Gonzalez, RA Stokes, J Chen, DR Laybutt, ME Craig, MM Swarbrick, C King, JE Gunton
    Cell Rep, 2019-05-21;27(8):2370-2384.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  103. Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity
    Authors: DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi
    Exp. Mol. Med., 2019-04-15;51(4):41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1?-dependent manner in macrophages
    Authors: OM Finucane, J Sugrue, A Rubio-Arai, MV Guillot-Se, MA Lynch
    Sci Rep, 2019-03-11;9(1):4034.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development
    Authors: Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu
    EBioMedicine, 2019-03-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  106. Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance
    Authors: S Morita-Tak, K Nakahara, S Hasegawa-I, A Isonishi, K Tatsumi, H Okuda, T Tanaka, M Kitabatake, T Ito, A Wanaka
    J Neuroinflammation, 2019-02-14;16(1):39.
    Species: Mouse
    Sample Types: Protein
  107. Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung
    Authors: JD Glenn, C Liu, KA Whartenby
    J. Leukoc. Biol., 2019-02-14;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
    Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
    Nat Commun, 2019-02-12;10(1):709.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
    Authors: K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota
    Nat Commun, 2019-02-01;10(1):549.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation
    Authors: Y Saeki, K Ishiyama, N Ishida, Y Tanaka, H Ohdan
    Sci Rep, 2019-01-31;9(1):1022.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Potential Novel Prediction of TMJ-OA: MiR-140-5p Regulates Inflammation Through Smad/TGF-? Signaling
    Authors: W Li, S Zhao, H Yang, C Zhang, Q Kang, J Deng, Y Xu, Y Ding, S Li
    Front Pharmacol, 2019-01-23;10(0):15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  112. BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis
    Authors: S Das, D Bar-Sagi
    Oncogene, 2019-01-11;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  113. REV-ERB? Regulates TH17 Cell Development and Autoimmunity
    Authors: M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt
    Cell Rep, 2018-12-26;25(13):3733-3749.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  114. EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-?B signaling pathway
    Authors: F Dou, X Chu, B Zhang, L Liang, G Lu, J Ding, S Chen
    Mol Brain, 2018-12-18;11(1):75.
    Species: Mouse
    Sample Types: Recombinant Protein
    Applications: ELISA (Standard)
  115. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
    Authors: R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang
    Oncogene, 2018-12-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. IL-23R Signaling Plays No Role in Myocardial Infarction
    Authors: E Engelowski, NF Modares, S Gorressen, P Bouvain, D Semmler, C Alter, Z Ding, U Flögel, J Schrader, H Xu, PA Lang, J Fischer, DM Floss, J Scheller
    Sci Rep, 2018-11-20;8(1):17078.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells
    Authors: F Mathies, N Steffens, D Kleinschmi, F Stuhlmann, FJ Huber, U Roy, T Meyer, M Luetgehetm, M von Peters, O Seiz, J Herkel, C Schramm, RA Flavell, N Gagliani, C Krebs, U Panzer, Z Abdullah, T Strowig, T Bedke, S Huber
    J. Immunol., 2018-11-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  118. TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism
    Authors: KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha
    Cell Death Dis, 2018-11-13;9(11):1130.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses
    Authors: CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel
    PLoS Pathog., 2018-10-26;14(10):e1007406.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Cutting Edge: IL-1? and Not IL-1? Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality
    Authors: JT Benjamin, DJ Moore, C Bennett, R van der Me, A Royce, R Loveland, JL Wynn
    J. Immunol., 2018-10-10;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  121. Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice
    Authors: HY Nam, JH Nam, G Yoon, JY Lee, Y Nam, HJ Kang, HJ Cho, J Kim, HS Hoe
    J Neuroinflammation, 2018-09-19;15(1):271.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard)
  122. Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue
    Authors: DB Ballak, S Li, G Cavalli, JL Stahl, IW Tengesdal, JA van Diepen, V Kluck, B Swartzwelt, T Azam, CJ Tack, R Stienstra, T Mandrup-Po, DR Seals, CA Dinarello
    J. Biol. Chem., 2018-07-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice
    Authors: CC Hsieh, CL Lin, JT He, M Chiang, Y Wang, YC Tsai, CH Hung, PJ Chang
    Stem Cell Res Ther, 2018-07-04;9(1):183.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Induction of innate immune memory via microRNA targeting of chromatin remodelling factors
    Authors: JJ Seeley, RG Baker, G Mohamed, T Bruns, MS Hayden, SD Deshmukh, DE Freedberg, S Ghosh
    Nature, 2018-06-27;559(7712):114-119.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
    Authors: DT Skelly, ÉW Griffin, CL Murray, S Harney, C O'Boyle, E Hennessy, MA Dansereau, A Nazmi, L Tortorelli, JN Rawlins, DM Bannerman, C Cunningham
    Mol. Psychiatry, 2018-06-06;24(10):1533-1548.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  126. Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1?
    Authors: HM Hsiao, R Fernandez, S Tanaka, W Li, JH Spahn, S Chiu, M Akbarpour, D Ruiz-Perez, Q Wu, C Turam, D Scozzi, T Takahashi, HP Luehmann, V Puri, GRS Budinger, AS Krupnick, AV Misharin, KJ Lavine, Y Liu, AE Gelman, A Bharat, D Kreisel
    J. Clin. Invest., 2018-05-21;128(7):2833-2847.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts
    Authors: H Kuwata, C Yuzurihara, N Kinoshita, Y Taki, Y Ikegami, S Washio, Y Hirakawa, E Yoda, T Aiuchi, H Itabe, Y Nakatani, S Hara
    FEBS J., 2018-04-18;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Role of IL-23 signaling in the progression of premalignant oral lesions to cancer
    Authors: B Caughron, Y Yang, MRI Young
    PLoS ONE, 2018-04-17;13(4):e0196034.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. A Nonpyroptotic IFN-?-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo
    Authors: JP Ingram, S Tursi, T Zhang, W Guo, C Yin, M A Wynosky-, J van der He, KQ Cai, M Yamamoto, BB Finlay, IE Brodsky, SI Grivenniko, Ç Tükel, S Balachandr
    J. Immunol., 2018-04-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
    Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
    Immunity, 2018-03-20;48(3):556-569.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection
    Authors: AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi
    J. Exp. Med., 2018-02-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. GPR142 prompts glucagon-like Peptide-1 release from islets to improve ? cell function
    Authors: HV Lin, J Wang, J Wang, W Li, X Wang, JT Alston, MK Thomas, DA Briere, SK Syed, AM Efanov
    Mol Metab, 2018-02-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  133. C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation
    Authors: CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber
    Elife, 2018-02-22;7(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  134. Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature
    Authors: W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi
    Neurobiol. Dis., 2018-02-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  135. Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells
    Authors: A Song, L Zhu, G Gorantla, O Berdysz, SA Amici, M Guerau-de-, KM Madalena, JK Lerch, X Liu, N Quan
    Sci Rep, 2018-01-15;8(1):723.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  136. Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis
    Authors: A Mancini, M Tantucci, P Mazzocchet, A de Iure, V Durante, L Macchioni, C Giampà, A Alvino, L Gaetani, C Costa, A Tozzi, P Calabresi, M Di Filippo
    Neurobiol. Dis., 2018-01-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  137. Pharmacological Effect ofCaulophyllum robustumon Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-?B, and Proinflammatory Cytokines In Vivo and In Vitro
    Authors: QH Wang, SW Lv, YY Guo, JX Duan, SY Dong, QS Wang, FM Yu, H Su, HX Kuang
    Evid Based Complement Alternat Med, 2017-12-31;2017(0):8134321.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain
    Authors: H Makino, S Seki, Y Yahara, S Shiozawa, Y Aikawa, H Motomura, M Nogami, K Watanabe, T Sainoh, H Ito, N Tsumaki, Y Kawaguchi, M Yamazaki, T Kimura
    Sci Rep, 2017-12-05;7(1):16983.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan
    Authors: SY Nam, KY Kim, MH Kim, JB Jang, SY Rah, HJ Chae, JM Lee, HM Kim, HJ Jeong
    Pharm Biol, 2017-12-01;55(1):1856-1862.
    Species: Mouse
    Sample Types:
    Applications: ELISA (Standard)
  140. IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells
    Authors: A Muschaweck, F Petermann, T Korn
    J. Immunol., 2017-08-30;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  141. The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle
    Authors: K Kamizaki, R Doi, M Hayashi, T Saji, M Kanagawa, T Toda, SI Fukada, HH Ho, ME Greenberg, M Endo, Y Minami
    J. Biol. Chem., 2017-08-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. The Role of Inflammation in ?-cell Dedifferentiation
    Authors: TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath
    Sci Rep, 2017-07-24;7(1):6285.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells
    Authors: C Wang, CX Xu, Y Alippe, C Qu, J Xiao, E Schipani, R Civitelli, Y Abu-Amer, G Mbalaviele
    Sci Rep, 2017-07-07;7(1):4880.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
    Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
    Eur. J. Immunol., 2017-06-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
    Authors: Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson
    J. Immunol., 2017-05-24;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Intestinal fungi contribute to development of alcoholic liver disease
    Authors: AM Yang, T Inamine, K Hochrath, P Chen, L Wang, C Llorente, S Bluemel, P Hartmann, J Xu, Y Koyama, T Kisseleva, MG Torralba, K Moncera, K Beeri, CS Chen, K Freese, C Hellerbran, SM Lee, HM Hoffman, WZ Mehal, G Garcia-Tsa, EA Mutlu, A Keshavarzi, GD Brown, SB Ho, R Bataller, P Stärkel, DE Fouts, B Schnabl
    J. Clin. Invest., 2017-05-22;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Prolactin blocks the expression of receptor activator of nuclear factor ?B ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
    Authors: MG Ledesma-Co, N Adán, G Ortiz, M Solís-Guti, F López-Barr, G Martínez d, C Clapp
    Arthritis Res. Ther., 2017-05-15;19(1):93.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  148. TNF? drives mitochondrial stress in POMC neurons in obesity
    Authors: CX Yi, M Walter, Y Gao, S Pitra, B Legutko, S Kälin, C Layritz, C García-Các, M Bielohuby, M Bidlingmai, SC Woods, A Ghanem, KK Conzelmann, JE Stern, M Jastroch, MH Tschöp
    Nat Commun, 2017-05-10;8(0):15143.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  149. ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
    Authors: Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich
    Mol Metab, 2017-05-06;6(7):725-736.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  150. IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
    Authors: F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux
    PLoS Pathog., 2017-04-27;13(4):e1006322.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  151. TNF-? promotes extracellular vesicle release in mouse astrocytes through glutaminase
    Authors: K Wang, L Ye, H Lu, H Chen, Y Zhang, Y Huang, JC Zheng
    J Neuroinflammation, 2017-04-20;14(1):87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs
    Authors: MX Li, HL Zheng, Y Luo, JG He, W Wang, J Han, L Zhang, X Wang, L Ni, HY Zhou, ZL Hu, PF Wu, Y Jin, LH Long, H Zhang, G Hu, JG Chen, F Wang
    Mol. Psychiatry, 2017-04-18;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  153. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
    Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
    J. Exp. Med., 2017-04-11;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  154. G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease
    Authors: MC Lee, JA McCubbin, AD Christense, DP Poole, P Rajasekhar, T Lieu, NW Bunnett, S Garcia-Car, A Erickson, SM Brierley, R Saleh, A Achuthan, AJ Fleetwood, RL Anderson, JA Hamilton, AD Cook
    J. Immunol, 2017-03-20;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  155. The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1?-induced inflammation in human fetal enterocytes via toll receptors 2 and 4
    Authors: F Jiang, D Meng, M Weng, W Zhu, W Wu, D Kasper, WA Walker
    PLoS ONE, 2017-03-09;12(3):e0172738.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  156. Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade
    Authors: D Sireesh, MR Ganesh, U Dhamodhara, M Sakthivadi, S Sivasubram, P Gunasekara, KM Ramkumar
    J. Nutr. Biochem, 2017-03-06;44(0):11-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  157. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4
    Authors: L Di Candia, E Gomez, E Venereau, L Chachi, D Kaur, ME Bianchi, RA Challiss, CE Brightling, RM Saunders
    J. Allergy Clin. Immunol, 2017-03-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
    Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
    J. Immunol, 2017-02-27;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Mesenchymal stem cells in alleviating sepsis-induced mice cardiac dysfunction via inhibition of mTORC1-p70S6K signal pathway
    Authors: W Huang, W Fan, Y Wang, D Han, X Li, S Li, C Li, B Xu, Y Huang, X Fu, F Cao
    Cell Death Discov, 2017-02-27;3(0):16097.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis
    Authors: S Choi, S You, D Kim, SY Choi, HM Kwon, HS Kim, D Hwang, YJ Park, CS Cho, WU Kim
    J. Clin. Invest, 2017-02-13;127(3):954-969.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  161. Early gene activation initiates neuroinflammation prior to VSV neuroinvasion: Impact on antiviral responses and sleep
    Authors: Richard P Ciavarra
    J. Neuroimmunol, 2016-12-29;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  162. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
    Sci Rep, 2016-12-14;6(0):39075.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  163. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016-12-01;6(0):37977.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis
    Authors: Stephen J Galli
    J. Clin. Invest., 2016-11-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  165. Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels
    PLoS ONE, 2016-09-23;11(9):e0163735.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  166. A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury
    J Immunol, 2016-08-24;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  167. IL-1? is an innate immune sensor of microbial proteolysis
    Authors: CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet
    Sci Immunol, 2016-08-19;1(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  168. TLR4-Upregulated IL-1? and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism
    Sci Rep, 2016-08-16;6(0):31663.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  169. SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
    Authors: Marie-Laure Michel
    Eur J Immunol, 2016-07-22;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Epidermal RAF prevents allergic skin disease
    Elife, 2016-07-19;5(0):.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
    Nature, 2016-07-13;535(7612):440-3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016-05-23;291(30):15830-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Platelets Guide Leukocytes to Their Sites of Extravasation
    PLoS Biol, 2016-05-06;14(5):e1002459.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  174. Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
    J Immunol, 2016-04-22;196(11):4731-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  175. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
    Authors: Shweta Pasi
    J Biol Chem, 2016-03-28;291(23):12358-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  176. HSP60 plays a regulatory role in IL-1beta-induced microglial inflammation via TLR4-p38 MAPK axis.
    Authors: Swaroop S, Sengupta N, Suryawanshi A, Adlakha Y, Basu A
    J Neuroinflammation, 2016-02-02;13(1):27.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  177. TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.
    Authors: Hu M, Xie X, Yang Q, Liao C, Ye W, Lin H, Shu H
    J Immunol, 2015-09-21;195(9):4415-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  178. Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
    Authors: Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E
    Nat Med, 2015-03-16;21(4):363-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.
    Authors: Liu X, Yamashita T, Chen Q, Belevych N, Mckim D, Tarr A, Coppola V, Nath N, Nemeth D, Syed Z, Sheridan J, Godbout J, Zuo J, Quan N
    J Neurosci, 2015-02-18;35(7):2860-70.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  180. IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
    Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
    J Immunol, 2015-02-18;194(6):2888-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
    Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
    J Immunol, 2015-02-11;194(6):2522-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  182. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015-02-02;16(3):286-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile.
    Authors: Cowardin C, Kuehne S, Buonomo E, Marie C, Minton N, Petri W
    MBio, 2015-01-27;6(1):.
    Species: Human, Mouse
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: Bioassay
  184. Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
    Authors: Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C
    J Neurosci, 2015-01-07;35(1):4-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.
    Authors: Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V
    Stem Cell Reports, 2014-12-31;4(1):25-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  186. Interleukin-1beta enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes.
    Authors: Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I
    PLoS ONE, 2014-12-31;9(12):e115603.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells.
    Authors: Jin, Shijie, Sonobe, Yoshifum, Kawanokuchi, Jun, Horiuchi, Hiroshi, Cheng, Yi, Wang, Yue, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
    PLoS ONE, 2014-12-23;9(12):e115981.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  188. A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.
    Authors: Dunne A, Mielke L, Allen A, Sutton C, Higgs R, Cunningham C, Higgins S, Mills K
    Mucosal Immunol, 2014-10-15;8(3):607-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.
    Authors: Glenn J, Smith M, Calabresi P, Whartenby K
    Stem Cells, 2014-10-01;32(10):2744-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway.
    Authors: Blum B, Roose A, Barrandon O, Maehr R, Arvanites A, Davidow L, Davis J, Peterson Q, Rubin L, Melton D
    Elife, 2014-09-16;3(0):e02809.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Role of Blimp-1 in programing Th effector cells into IL-10 producers.
    Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
    J Exp Med, 2014-07-29;211(9):1807-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  192. Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2alpha.
    Authors: Grabiner M, Fu Z, Wu T, Barry K, Schwarzer C, Machen T
    J Immunol, 2014-07-02;193(3):1459-67.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  193. Glimepiride reduces CD14 expression and cytokine secretion from macrophages.
    Authors: Ingham V, Williams A, Bate C
    J Neuroinflammation, 2014-06-21;11(0):115.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard)
  194. A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion.
    Authors: Bakker P, Butter L, Claessen N, Teske G, Sutterwala F, Florquin S, Leemans J
    Am J Pathol, 2014-05-11;184(7):2013-22.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  195. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
    Authors: Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
    J Biol Chem, 2014-04-22;289(22):15621-30.
    Species: Bacteria - Porphyromonas gingivalis, Mouse
    Sample Types: Protein, Whole Cells
    Applications: Bioassay, Degradation
  196. Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis.
    Authors: Jana M, Mondal S, Jana A, Pahan K
    Immunology, 2014-04-01;141(4):549-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  197. IFN-gamma or IFN-alpha ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.
    Authors: Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, Iwai K
    J Immunol, 2014-03-14;192(8):3793-804.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  198. Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics.
    Authors: Hahn W, Kuzmicic J, Burrill J, Donoghue M, Foncea R, Jensen M, Lavandero S, Arriaga E, Bernlohr D
    Am J Physiol Endocrinol Metab, 2014-03-04;306(9):E1033-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  199. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
    Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
    Nat Med, 2013-12-22;20(1):62-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  200. ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.
    Authors: Halai, Krishma, Whiteford, James, Ma, Bin, Nourshargh, Sussan, Woodfin, Abigail
    J Cell Sci, 2013-12-06;127(0):620-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  201. Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production.
    Authors: Lee S, Lee K, Yi S, Kook S, Lee J
    PLoS ONE, 2013-12-04;8(12):e80873.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  202. A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex.
    Authors: Zehendner, Christop, Wedler, Hannah E, Luhmann, Heiko J
    PLoS ONE, 2013-11-21;8(11):e81637.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  203. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
    Authors: Moon C, VanDussen K, Miyoshi H, Stappenbeck T
    Mucosal Immunol, 2013-11-13;7(4):818-28.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  204. IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors.
    Authors: Valcarcel M, Carrascal T, Crende O, Vidal-Vanaclocha F
    J Invest Dermatol, 2013-08-12;134(2):470-80.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.
    Authors: Steelman A, Smith R, Welsh C, Li J
    J Biol Chem, 2013-07-08;288(33):23776-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  206. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth.
    Authors: Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J
    PLoS ONE, 2013-04-02;8(4):e60226.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  207. IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
    Authors: Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S
    J Immunol, 2013-03-13;190(8):4196-204.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  208. In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1beta-induced peritonitis.
    Authors: Song J, Wu C, Zhang X, Sorokin L
    J Immunol, 2012-12-07;190(1):401-10.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  209. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
    Authors: Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F
    Nat Med, 2012-12-02;19(1):57-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  210. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
    J. Exp. Med., 2012-07-16;209(8):1505-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  211. Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
    Authors: Flanagan K, Fitzgerald K, Baker J
    PLoS ONE, 2012-07-06;7(7):e40443.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  212. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  213. Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice.
    Authors: Zhao H, Zhao X, Cao X, Wu G
    Immun Ageing, 2012-05-28;9(1):12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  214. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.
    Authors: Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S
    J. Exp. Med., 2012-05-21;209(6):1219-34.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  215. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice.
    Authors: Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algul H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP
    J. Clin. Invest., 2012-04-02;122(5):1758-63.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  216. Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression.
    Authors: Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W
    Mol. Endocrinol., 2012-04-02;26(5):775-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  217. Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection.
    Authors: Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK
    Infect. Immun., 2011-10-24;80(1):398-409.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  218. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
    Authors: El-Behi M, Ciric B, Dai H
    Nat. Immunol., 2011-04-24;12(6):568-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  219. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011-03-07;208(3):491-503.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  220. Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors.
    Authors: Sanchez-Alavez M, Osborn O, Tabarean IV
    J. Biol. Chem., 2011-02-17;286(17):14983-90.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  221. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases.
    Authors: Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L
    MAbs, 2011-01-01;3(1):49-60.
    Species: Mouse
    Sample Types: Buffer
    Applications: Binding Assay
  222. Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo.
    Authors: Petri B, Kaur J, Long EM, Li H, Parsons SA, Butz S, Phillipson M, Vestweber D, Patel KD, Robbins SM, Kubes P
    Blood, 2010-10-28;117(3):942-52.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  223. Tim3 binding to galectin-9 stimulates antimicrobial immunity.
    Authors: Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM
    J. Exp. Med., 2010-10-11;207(11):2343-54.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  224. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010-09-29;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  225. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
    Authors: Chou RC, Kim ND, Sadik CD
    Immunity, 2010-08-27;33(2):266-78.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  226. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
    Authors: Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS
    J. Clin. Invest., 2010-04-01;120(5):1762-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  227. Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.
    Authors: Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL
    Endocrinology, 2009-12-16;151(2):606-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  228. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
    Authors: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
    J. Immunol., 2009-12-15;183(12):7890-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  229. Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept.
    Authors: Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P
    Brain Behav. Immun., 2009-10-25;24(5):747-58.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  230. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
    Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
    J. Immunol., 2009-10-19;183(10):6135-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  231. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
    Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
    Nat. Med., 2009-09-20;15(10):1170-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  232. Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
    Authors: Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
    J. Immunol., 2009-08-28;183(6):4021-30.
    Applications: Western Blot
  233. Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
    Authors: Mizutani N, Nabe T, Yoshino S
    J. Immunol., 2009-08-14;183(6):4039-46.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  234. The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.
    Authors: Koziczak-Holbro M, Littlewood-Evans A, Pollinger B, Kovarik J, Dawson J, Zenke G, Burkhart C, Muller M, Gram H
    Arthritis Rheum., 2009-06-01;60(6):1661-71.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  235. The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
    Authors: Nilsberth C, Elander L, Hamzic N, Norell M, Lonn J, Engstrom L, Blomqvist A
    Endocrinology, 2008-11-20;150(4):1850-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  236. A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs.
    Authors: Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A
    Arthritis Rheum., 2008-11-01;58(11):3510-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  237. Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
    Authors: Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL
    Endocrinology, 2008-06-26;149(10):4837-45.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  238. Induction of IL-33 expression and activity in central nervous system glia.
    Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
    J. Leukoc. Biol., 2008-06-13;84(3):631-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  239. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
    Authors: Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG
    Am. J. Pathol., 2008-06-05;173(1):57-67.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  240. In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model.
    Authors: Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M
    Cell. Immunol., 2008-05-20;251(2):78-85.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  241. Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice.
    Authors: Olivadoti MD, Opp MR
    Neuroscience, 2008-02-19;153(1):338-48.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  242. IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8.
    Authors: Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O'Neill LA, Mills KH, Lynch MA
    J. Neurochem., 2008-02-18;105(5):1960-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  243. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis.
    Authors: Antonopoulos C, Cumberbatch M, Mee JB, Dearman RJ, Wei XQ, Liew FY, Kimber I, Groves RW
    J. Leukoc. Biol., 2007-11-05;83(2):361-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  244. Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.
    Authors: Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J
    Nat. Immunol., 2007-05-13;8(6):601-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  245. Protection of CD8+ T cells from activation-induced cell death by IL-18.
    Authors: Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H
    J. Leukoc. Biol., 2007-03-30;82(1):142-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  246. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice.
    Authors: Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG
    Inflamm. Res., 2006-11-01;55(11):457-64.
    Applications: ELISA (Standard)
  247. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
    Authors: Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
    Genes Dev., 2006-09-15;20(18):2527-38.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  248. A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
    Authors: Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M
    J. Mol. Cell. Cardiol., 2006-09-11;41(5):885-92.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  249. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006-08-01;177(3):1967-74.
    Applications: ELISA (Standard)
  250. Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide.
    Authors: Vickers TA, Zhang H, Graham MJ, Lemonidis KM, Zhao C, Dean NM
    J. Immunol., 2006-03-15;176(6):3652-61.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  251. Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury.
    Authors: Mendez MP, Morris SB, Wilcoxen S, Greeson E, Moore B, Paine R
    Am. J. Physiol. Lung Cell Mol. Physiol., 2005-12-22;290(5):L962-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  252. TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice.
    Authors: Ojaniemi M, Liljeroos M, Harju K, Sormunen R, Vuolteenaho R, Hallman M
    Immunol. Lett., 2005-09-26;102(2):158-68.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  253. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005-07-01;302(1):172-81.
    Applications: ELISA (Standard)
  254. IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system.
    Authors: Ching S, He L, Lai W, Quan N
    Brain Behav. Immun., 2005-03-01;19(2):127-37.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  255. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2005-02-26;231(1):103-11.
    Applications: ELISA (Standard)
  256. Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
    Authors: Perrin FE, Lacroix S, Aviles-Trigueros M, David S
    Brain, 2005-02-02;128(0):854-66.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

FAQs

  1. Does IL-1 beta induce NO in smooth muscle?

    • Yes it does, based on the literature.

  2. Can Recombinant Mouse IL-1 beta/IL-1F2 Protein (Catalog # 401-ML) be used in rat or human cells?

    • Bioactivity of Recombinant Mouse IL-1 beta Protein (Catalog # 401-ML) has only been evaluated using mouse cells. We offer both Recombinant Human IL-1 beta Protein (Catalog # 201-IL) and Recombinant Rat IL-1 beta Protein (Catalog # 501-RL) that we recommend for use in human and rat assay systems.

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Recombinant Mouse IL-1 beta/IL-1F2 Protein
By Anonymous on 10/05/2020
Application: In vitro bioactivity in cell culture
Recombinant Mouse IL-1 beta/IL-1F2 Protein
By Anonymous on 03/17/2020
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: Good for Th17 Differentiation
Stem/Immune cell maintenance or differentiation Recombinant Mouse IL-1 beta/IL-1F2 Protein 401-ML
Recombinant Mouse IL-1 beta/IL-1F2 Protein
By Anonymous on 03/06/2020
Application: In vivo study
Recombinant Mouse IL-1 beta/IL-1F2 Protein
By Anonymous on 01/15/2020
Application: In vitro bioactivity in cell culture
Recombinant Mouse IL-1 beta/IL-1F2 Protein
By Jim Hsiao on 12/15/2017
Application: Inflammatory stimulant
Reason for Rating: Primary mouse fibroblasts were treated with IL1b for 24 hours. The supernatant was collected and analyzed for IL-6.


Other Recombinant Mouse IL-1 beta/IL-1F2 Protein 401-ML
Recombinant Mouse IL-1 beta/IL-1F2 Protein
By Anonymous on 08/02/2017
Application: In vitro bioactivity in cell culture
In vitro bioactivity in cell culture Recombinant Mouse IL-1 beta/IL-1F2 Protein 401-ML
Recombinant Mouse IL-1 beta/IL-1F2 Protein
By Anonymous on 01/13/2016
Application: Apoptosis assay
Reason for Rating: I have a good apoptosis results

I treat the IL-1 beta with IFN-gamma in beta-Tc3 cells.
Cell death rate is almost 30% for 48 hrs.