Recombinant Mouse IL-11 Protein Summary
Product Specifications
Gly23-Leu199, with an N-terminal Met and Pro25-Leu199
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
418-ML
| Formulation | Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol and Tween® 80 with Trehalose and with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile, deionized water. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
418-ML/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol and Tween® 80 with Trehalose. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile, deionized water. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: IL-11
IL-11 (Interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27 and IL-31 (1-4). In humans, IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF) (3). The mouse IL-11 cDNA encodes a 199 amino acid (aa) precursor, which generates a 178 aa, 19 kDa mature unglycosylated protein. Mature mouse IL-11 shares 88%, 97%, and 89% aa sequence identity with human, rat and canine IL-11, respectively. IL-11 is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts, among other cell types (1). It is found in the plasma mainly during inflammation, such as that associated with viral infection, cancer, or inflammatory arthritis, and is considered to be primarily anti‑inflammatory (1). It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine (1). It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis (1). IL-11 synergizes with several other cytokines to produce these effects, and its effects overlap with those of IL-6 (1). IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11 R alpha subunit and two molecules of the ubiquitously expressed cell signaling beta subunit, gp130 (5). A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface, or inhibit cell surface IL-11 R alpha /gp130 signaling (6-8).
- Putoczki, T. and M. Ernst (2010) J. Leukoc. Biol. 88:1109.
- Paul, S.R. et al. (1990) Proc. Natl. Acad. Sci. USA 87:7512.
- Kawashima, I. et al. (1991) FEBS Lett. 283:199.
- Morris, J.C. et al. (1996) Exp. Hematol. 24:1369.
- Barton, V.A. et al. (2000) J. Biol. Chem. 275:36197.
- Curtis, D.J. et al. (1997) Blood 90:4403.
- Baumann, H. et al. (1996) J. Immunol. 157:284.
- Karow, J. et al. (1996) Biochem. J. 318:489.
Citations for Recombinant Mouse IL-11 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors
Authors: J Wu, K Krchma, HJ Lee, S Prabhakar, X Wang, H Zhao, X Xing, RH Seong, DH Fremont, MN Artyomov, T Wang, K Choi
Cell Rep, 2020-11-17;33(7):108395.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Authors: X Zhang, N Kiapour, S Kapoor, T Khan, M Thamilaras, Y Tao, S Cohen, R Miller, RA Sobel, S Markovic-P
J. Immunol., 2019-07-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation
Authors: MJ Delás, BT Jackson, T Kovacevic, S Vangelisti, E Munera Mar, SA Wild, EM Stork, N Erard, SRV Knott, GJ Hannon
Cell Rep, 2019-04-16;27(3):719-729.e6.
Species: Mouse
Sample Types: cell culture
Applications: Cell Culture -
Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells
Authors: KR Wilson, IH Kang, U Baliga, Y Xiong, S Chatterjee, E Moore, B Parthiban, K Thyagaraja, JL Borke, S Mehrotra, KL Kirkwood, AC LaRue, M Ogawa, M Mehrotra
Sci Rep, 2018-05-23;8(1):8026.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A single cell hematopoietic landscape resolves eight lineage trajectories and defects in Kit mutant mice
Authors: JS Dahlin, FK Hamey, B Pijuan-Sal, M Shepherd, WWY Lau, S Nestorowa, C Weinreb, S Wolock, R Hannah, E Diamanti, DG Kent, B Göttgens, NK Wilson
Blood, 2018-03-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects
Authors: JE Draper, P Sroczynska, MZH Fadlullah, R Patel, G Newton, W Breitwiese, V Kouskoff, G Lacaud
PLoS Genet., 2018-01-04;14(1):e1007127.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway
Authors: S Ollila, E Domènech-M, K Laajanen, IP Wong, S Tripathi, N Pentinmikk, Y Gao, Y Yan, EH Niemelä, TC Wang, B Viollet, G Leone, P Katajisto, K Vaahtomeri, TP Mäkelä
J. Clin. Invest., 2017-12-04;0(0):.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
Nat. Methods, 2017-04-10;14(5):531-538.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the in Vivo Regeneration of the Hematopoietic Stem Cell Pool
Authors: Franziska Ruf
Stem Cells, 2016-06-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis
PLoS ONE, 2016-05-09;11(5):e0154630.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia.
Authors: Seto D, Kandarian S, Jackman R
J Biol Chem, 2015-06-19;290(32):19976-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor.
Authors: Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K
Stem Cells, 2015-03-01;33(3):976-87.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor.
Authors: Figueiredo C, Drohomyrecky P, McCarthy S, Leontyev D, Ma X, Branch D, Dunn S
PLoS ONE, 2014-07-31;9(7):e101947.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Authors: Carnevalli L, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jockel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers M, Trumpp A
J Exp Med, 2014-04-21;211(5):769-79.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines.
Authors: Verovskaya, Evgenia, Broekhuis, Mathilde, Zwart, Erik, Weersing, Ellen, Ritsema, Martha, Bosman, Lisette, van Poele, Theo, de Haan, Gerald, Bystrykh, Leonid V
J Exp Med, 2014-02-24;211(3):487-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq.
Authors: Elsaeidi, Fairouz, Bemben, Michael, Zhao, Xiao-Fen, Goldman, Daniel
J Neurosci, 2014-02-12;34(7):2632-44.
Species: Zebrafish
Sample Types: Whole Tissue
Applications: Bioassay -
Identification of transcription factors for lineage-specific ESC differentiation.
Authors: Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M
Stem Cell Reports, 2013-11-27;1(6):545-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
Authors: Cook BD, Liu S, Evans T
Blood, 2011-04-22;117(24):6489-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cold pre-conditioning neuroprotection depends on TNF-alpha and is enhanced by blockade of interleukin-11.
Authors: Mitchell HM, White DM, Domowicz MS, Kraig RP
J. Neurochem., 2010-12-01;117(2):187-96.
Species: Rat
Sample Types: Whole Tissue
Applications: Bioassay -
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Authors: Stumhofer JS, Tait ED, Quinn WJ, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grotzinger J, Cancro MP, Levin SD, Hunter CA
Nat. Immunol., 2010-11-07;11(12):1119-26.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
J. Virol., 2010-09-29;84(24):12703-12.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes.
Authors: Krejci P, Prochazkova J, Bryja V, Jelinkova P, Pejchalova K, Kozubik A, Thompson LM, Wilcox WR
Cell. Signal., 2008-10-12;21(1):151-60.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation.
Authors: Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR
J. Neurosci., 2006-11-22;26(47):12174-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
Blood, 2006-05-23;108(6):2041-4.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
Arch. Dermatol. Res., 2001-11-01;293(10):508-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
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