Recombinant Mouse IL-17C Protein Summary
Product Specifications
His15-Gln194, with an N-terminal Met
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
2306-ML
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
2306-ML/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile 4 mM HCl. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: IL-17C
Interleukin-17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold (1, 2). Mature mouse IL‑17C shares 79% and 95% amino acid sequence identity with human and rat IL‑17C, respectively (3). IL‑17C binds to IL‑17 RE with high affinity and to IL‑17 RA with low affinity (4, 5). These two receptor chains can associate into a heterodimeric receptor for IL‑17C (4‑6). IL-17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma /δ T cells, while IL-17 RA is widely expressed (4, 5). IL‑17 RE is required for mediating the pro-inflammatory and homeostatic actions of IL‑17C in the skin and mucosa (1, 2). IL‑17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells (4, 6‑9). It is up‑regulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD) (7 8, 10). IL‑17 RE is reciprocally downregulated in psoriatic lesions (10). The interaction of IL‑17C with IL‑17 RE promotes mucosal immunity through the induction of anti-bacterial peptides and pro‑inflammatory cytokines and chemokines (4, 6, 8, 9). IL‑17C action supports the integrity of the colon epithelium following infection induced damage (4, 6, 11) but also contributes to psoriatic skin thickening and the progression of arthritis (4,8, 9). IL‑17C is additionally up‑regulated in Th17 cell dependent autoimmunity (5). In this setting, it exacerbates disease severity by inducing Th17 cell production of IL‑17A, IL‑17F, IL‑22, CCR6, and CCL20 (5).
- Pappu, R. et al. (2012) Trends Immunol. 33:343.
- Rubino, S.J. et al. (2012) Trends Immunol. 33:112.
- Hurst, S.D. et al. (2002) J. Immunol. 169:443.
- Ramirez-Carrozzi, V. et al. (2011) Nat. Immunol. 12:1159.
- Chang, S.H. et al. (2011) Immunity 35:611.
- Song, X. et al. (2011) Nat. Immunol. 12:1151.
- Pfeifer, P. et al. (2012) Am. J. Respir. Cell Mol. Biol. 48:415.
- Johnston, A. et al. (2013) J. Immunol. 190:2252.
- Yamaguchi, Y. et al. (2007) J. Immunol. 179:7128.
- Johansen, C. et al. (2009) Br. J. Dermatol. 160:319.
- Reynolds, J.M. et al. (2012) J. Immunol. 189:4226.
Citations for Recombinant Mouse IL-17C Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer
Authors: F Ritzmann, C Jungnickel, G Vella, A Kamyschnik, C Herr, D Li, MM Menger, A Angenendt, M Hoth, A Lis, R Bals, C Beisswenge
Sci Rep, 2019-07-17;9(1):10353.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
The roles of IL-17C in T cell-dependent and -independent inflammatory diseases
Authors: S Yamaguchi, A Nambu, T Numata, T Yoshizaki, S Narushima, E Shimura, Y Hiraishi, K Arae, H Morita, K Matsumoto, I Hisatome, K Sudo, S Nakae
Sci Rep, 2018-10-24;8(1):15750.
Species: Mouse
Sample Types: Peritoneal Lavage Fluid
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Average Rating: 5 (Based on 1 Review)
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Reason for Rating: Really easy to reconstitute
